Sildenafil Improves Right Ventricular Function, Exercise Capacity, and Quality of Life in Patients with Biventricular Dysfunction: Results from a Randomised Study

Vikas K| Saurabh Mehrotra| Ashwani Sood| Yashpaul Sharma

2020, Vol: 11, Issue: 3

11/3Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

« Previous Article

Original Research (Original Article)

. 2020; 11(3): 85-89

doi: 10.31838/jcdr.2020.11.03.20

Sildenafil Improves Right Ventricular Function, Exercise Capacity, and Quality of Life in Patients with Biventricular Dysfunction: Results from a Randomised Study

Vikas K, Saurabh Mehrotra, Ashwani Sood, Yashpaul Sharma.

Abstract
Background: Phosphodiesterase-5 (PDE-5) inhibitors have shown beneficial effects in heart failure owing to their propensity to dilate the pulmonary vasculature, enhance the right ventricular contractility, and improve the ventricular interdependence. However, their effect in biventricular failure remains unclear. We evaluated the effect of sildenafil, a selective PDE-5 inhibitor, on ventricular function, exercise capacity, and quality of life (QoL) in patients with biventricular dysfunction.

Methods: Patients aged 18 years or older with pulmonary hypertension secondary to biventricular dysfunction, despite optimal medical therapy were randomised to receive either sildenafil 20 mg thrice a day or placebo for 3 months. Clinical investigations such as coronary angiogram, 6-minute walk distance (6MWD), Minnesota Living with Heart Failure questionnaire (MLHFQ), 2D echocardiogram (2D ECHO), right and left ventricular ejection fraction by first pass radionuclide scan and right heart hemodynamics were performed at baseline and at 3 months.

Results: 38 patients aged â‰¥18 years with biventricular dysfunction (<40%) were included in the study. Sildenafil significantly improved the right ventricular ejection fraction (RVEF), right ventricular systolic pressure and 6-minute walk distance (p < 0.05) as compared to the placebo group. There were fewer hospitalizations for heart failure in the sildenafil group as compared to placebo group (2 vs. 5; p < 0.05). No significant differences in the occurrence of adverse events was noted amongst the two groups except for headache, which was more frequent in the sildenafil group.

Conclusion: Sildenafil has a beneficial effect on right ventricular function, exercise capacity, and QoL in patients with biventricular dysfunction with secondary pulmonary hypertension.

Key words: Heart Failure (HF), Pulmonary Vascular Resistance (PVR), 6-Minute Walk Distance (6MWD), Right Ventricle Ejection Fraction (RVEF)

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Vikas K Articles by Saurabh Mehrotra Articles by Ashwani Sood Articles by Yashpaul Sharma
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Vikas K, Saurabh Mehrotra, Ashwani Sood, Yashpaul Sharma. Sildenafil Improves Right Ventricular Function, Exercise Capacity, and Quality of Life in Patients with Biventricular Dysfunction: Results from a Randomised Study. . 2020; 11(3): 85-89. doi:10.31838/jcdr.2020.11.03.20

Web Style

Vikas K, Saurabh Mehrotra, Ashwani Sood, Yashpaul Sharma. Sildenafil Improves Right Ventricular Function, Exercise Capacity, and Quality of Life in Patients with Biventricular Dysfunction: Results from a Randomised Study. http://www.jcdronline.org//?mno=115107 [Access: July 31, 2020]. doi:10.31838/jcdr.2020.11.03.20

AMA (American Medical Association) Style

Vikas K, Saurabh Mehrotra, Ashwani Sood, Yashpaul Sharma. Sildenafil Improves Right Ventricular Function, Exercise Capacity, and Quality of Life in Patients with Biventricular Dysfunction: Results from a Randomised Study. . 2020; 11(3): 85-89. doi:10.31838/jcdr.2020.11.03.20

Vancouver/ICMJE Style

Vikas K, Saurabh Mehrotra, Ashwani Sood, Yashpaul Sharma. Sildenafil Improves Right Ventricular Function, Exercise Capacity, and Quality of Life in Patients with Biventricular Dysfunction: Results from a Randomised Study. . (2020), [cited July 31, 2020]; 11(3): 85-89. doi:10.31838/jcdr.2020.11.03.20

Harvard Style

Vikas K, Saurabh Mehrotra, Ashwani Sood, Yashpaul Sharma (2020) Sildenafil Improves Right Ventricular Function, Exercise Capacity, and Quality of Life in Patients with Biventricular Dysfunction: Results from a Randomised Study. , 11 (3), 85-89. doi:10.31838/jcdr.2020.11.03.20

Turabian Style

Vikas K, Saurabh Mehrotra, Ashwani Sood, Yashpaul Sharma. 2020. Sildenafil Improves Right Ventricular Function, Exercise Capacity, and Quality of Life in Patients with Biventricular Dysfunction: Results from a Randomised Study. Journal of Cardiovascular Disease Research, 11 (3), 85-89. doi:10.31838/jcdr.2020.11.03.20

Chicago Style

Vikas K, Saurabh Mehrotra, Ashwani Sood, Yashpaul Sharma. "Sildenafil Improves Right Ventricular Function, Exercise Capacity, and Quality of Life in Patients with Biventricular Dysfunction: Results from a Randomised Study." Journal of Cardiovascular Disease Research 11 (2020), 85-89. doi:10.31838/jcdr.2020.11.03.20

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Author Login Reviewer Login About Publisher Editorial Policies Peer Review Policy Editorial & Peer Review Process Author's Rights and Obligations Publication Ethics and Publication Malpractice Statement Conflict of Interest Policy Plagiarism Policy Protection of Research Participants (Statement On Human And Animal Rights) Privacy Policy Publishing Ethics Corrections, Retractions & Expressions of Concern Self-Archiving Policies Statement of Informed Consent Advertising Policy Terms of Use License Information

This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. This is in accordance with the Budapest Open Access Initiative (BOAI) definition of open access. The articles in Journal of Cardiovascular Disease Research are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

Copyright © 2020 Journal of Cardiovascular Disease Research All Rights Reserved. Subject to change without notice from or liability to Journal of Cardiovascular Disease Research. For best results, please use Internet Explorer or Google Chrome	Contact Information Branch Office/Support Office for journal: Journal of Cardiovascular Disease Research Publication Office Advanced Scientific Research, 21, Thyamotharan Street, Arisipalayam Salem - 636009 Email : editorjcdr2010@gmail.com support : help.jcdr@gmail.com

Contact Information

How to cite this article