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Original Research (Original Article) 


Sildenafil Improves Right Ventricular Function, Exercise Capacity, and Quality of Life in Patients with Biventricular Dysfunction: Results from a Randomised Study

Vikas K, Saurabh Mehrotra, Ashwani Sood, Yashpaul Sharma.

Abstract
Background: Phosphodiesterase-5 (PDE-5) inhibitors have shown beneficial effects in heart failure owing to their propensity to dilate the pulmonary vasculature, enhance the right ventricular contractility, and improve the ventricular interdependence. However, their effect in biventricular failure remains unclear. We evaluated the effect of sildenafil, a selective PDE-5 inhibitor, on ventricular function, exercise capacity, and quality of life (QoL) in patients with biventricular dysfunction.

Methods: Patients aged 18 years or older with pulmonary hypertension secondary to biventricular dysfunction, despite optimal medical therapy were randomised to receive either sildenafil 20 mg thrice a day or placebo for 3 months. Clinical investigations such as coronary angiogram, 6-minute walk distance (6MWD), Minnesota Living with Heart Failure questionnaire (MLHFQ), 2D echocardiogram (2D ECHO), right and left ventricular ejection fraction by first pass radionuclide scan and right heart hemodynamics were performed at baseline and at 3 months.

Results: 38 patients aged ≥18 years with biventricular dysfunction (<40%) were included in the study. Sildenafil significantly improved the right ventricular ejection fraction (RVEF), right ventricular systolic pressure and 6-minute walk distance (p < 0.05) as compared to the placebo group. There were fewer hospitalizations for heart failure in the sildenafil group as compared to placebo group (2 vs. 5; p < 0.05). No significant differences in the occurrence of adverse events was noted amongst the two groups except for headache, which was more frequent in the sildenafil group.

Conclusion: Sildenafil has a beneficial effect on right ventricular function, exercise capacity, and QoL in patients with biventricular dysfunction with secondary pulmonary hypertension.

Key words: Heart Failure (HF), Pulmonary Vascular Resistance (PVR), 6-Minute Walk Distance (6MWD), Right Ventricle Ejection Fraction (RVEF)


 
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How to Cite this Article
Pubmed Style

Vikas K, Saurabh Mehrotra, Ashwani Sood, Yashpaul Sharma. Sildenafil Improves Right Ventricular Function, Exercise Capacity, and Quality of Life in Patients with Biventricular Dysfunction: Results from a Randomised Study. . 2020; 11(3): 85-89. doi:10.31838/jcdr.2020.11.03.20

Web Style

Vikas K, Saurabh Mehrotra, Ashwani Sood, Yashpaul Sharma. Sildenafil Improves Right Ventricular Function, Exercise Capacity, and Quality of Life in Patients with Biventricular Dysfunction: Results from a Randomised Study. http://www.jcdronline.org//?mno=115107 [Access: July 31, 2020]. doi:10.31838/jcdr.2020.11.03.20

AMA (American Medical Association) Style

Vikas K, Saurabh Mehrotra, Ashwani Sood, Yashpaul Sharma. Sildenafil Improves Right Ventricular Function, Exercise Capacity, and Quality of Life in Patients with Biventricular Dysfunction: Results from a Randomised Study. . 2020; 11(3): 85-89. doi:10.31838/jcdr.2020.11.03.20


Vancouver/ICMJE Style

Vikas K, Saurabh Mehrotra, Ashwani Sood, Yashpaul Sharma. Sildenafil Improves Right Ventricular Function, Exercise Capacity, and Quality of Life in Patients with Biventricular Dysfunction: Results from a Randomised Study. . (2020), [cited July 31, 2020]; 11(3): 85-89. doi:10.31838/jcdr.2020.11.03.20


Harvard Style

Vikas K, Saurabh Mehrotra, Ashwani Sood, Yashpaul Sharma (2020) Sildenafil Improves Right Ventricular Function, Exercise Capacity, and Quality of Life in Patients with Biventricular Dysfunction: Results from a Randomised Study. , 11 (3), 85-89. doi:10.31838/jcdr.2020.11.03.20


Turabian Style

Vikas K, Saurabh Mehrotra, Ashwani Sood, Yashpaul Sharma. 2020. Sildenafil Improves Right Ventricular Function, Exercise Capacity, and Quality of Life in Patients with Biventricular Dysfunction: Results from a Randomised Study. Journal of Cardiovascular Disease Research, 11 (3), 85-89. doi:10.31838/jcdr.2020.11.03.20


Chicago Style

Vikas K, Saurabh Mehrotra, Ashwani Sood, Yashpaul Sharma. "Sildenafil Improves Right Ventricular Function, Exercise Capacity, and Quality of Life in Patients with Biventricular Dysfunction: Results from a Randomised Study." Journal of Cardiovascular Disease Research 11 (2020), 85-89. doi:10.31838/jcdr.2020.11.03.20


MLA (The Modern Language Association) Style

Vikas K, Saurabh Mehrotra, Ashwani Sood, Yashpaul Sharma. "Sildenafil Improves Right Ventricular Function, Exercise Capacity, and Quality of Life in Patients with Biventricular Dysfunction: Results from a Randomised Study." Journal of Cardiovascular Disease Research 11.3 (2020), 85-89. Print. doi:10.31838/jcdr.2020.11.03.20


APA (American Psychological Association) Style

Vikas K, Saurabh Mehrotra, Ashwani Sood, Yashpaul Sharma (2020) Sildenafil Improves Right Ventricular Function, Exercise Capacity, and Quality of Life in Patients with Biventricular Dysfunction: Results from a Randomised Study. Journal of Cardiovascular Disease Research, 11 (3), 85-89. doi:10.31838/jcdr.2020.11.03.20




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