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Original Research (Original Article) 


Comorbid States in Patients with Chronic Heart Failure. Regional Level of the Problem (Preliminary Study)

Tosheva Khakima Bekmurodovna, Erkinova Nigora Erkinovna, Gadaev Abdigaffar Gadaevich, Djuraeva Nozima Oripovna, Khalilova Feruza Abduzhalolovna.

Abstract
Purpose of the study: To study comorbid conditions in patients with heart failure living in regions with a hot climate.

Research materials: 323 patients were examined who were hospitalized in the cardiology department of Bukhara, in one of the southern and hottest regions of Uzbekistan, where the temperature of the thermometer rises above 400С. Among the examined patients were 150 men (46.43%), 173 women (53.56%). All patients had heart failure and were divided by age into 2 groups up to 59 years old - 161 people and the second group-162 people - over 60 years old. The average age in group 1 was 52.55 + 6.42 years, the average age in group 2 was 67.56 + 6.7 years (p <0.001). CHF was diagnosed and evaluated in accordance with the recommendation of the New York Heart Society. All patients underwent general clinical and laboratory examinations, electrocardiography, and were interviewed using the Minnesota Questionnaire.

Research results and discussion: According to FC, patients were distributed as follows: I FC-26.93%; II FC-50.51%; III FC-22.29%; IV-0.26%. The average body mass index in the group under 60 years old was 29.4 + 4.9 years, in the second group over 60 years old - 28.1 (m + 4.5).
All patients had comorbid conditions. So, with one concomitant diagnosis, there were 43 patients - this amounted to 13.31% of patients, with two concomitant diagnoses of 214 patients, which amounted to 66.25%. With three concomitant pathologies - 56 patients, which amounted to 17.33% of patients. 9 patients with concomitant pathologies had 4 or more, accounting for 2.78%. On average, the total comorbidity averaged 2.1 + 0.67, in the group under 60 this indicator was 1.9 (m + 0.53), in the group over 60 years old - 2.2 + 0.75, (p <0.05). When assessing comorbidity by functional classes, it was found that in patients with 1 FC among 87 people, the comorbidity was 1.74 + 0.61, in patients with 2 FC in 164 patients it was 2.1 + 0.57 in patients with 3 FC among 72 patients comorbidity was 2.54 + 0.65. The analysis showed that with age and an increase in FC CHF, the frequency of comorbid conditions increases in parallel and is most often diagnosed in older age groups with III-FC CHF. The most common concomitant pathologies of coronary heart disease were diabetes, anemia, obesity, fatty liver disease, deforming osteoarthritis, osteochondrosis. Patients were divided into two groups depending on the hemoglobin indices of blood. In the first group, hemoglobin indices amounted to 112.4 + 10.2, in the second group hemoglobin 134.9 + 8.9 (P <0.05). The analysis showed that anemia is often diagnosed in patients with older heart failure, and the frequency increases depending on the FC disease.
In addition, in order to study renal dysfunction in heart failure, the number of patients with albuminuria and blood creatinine was analyzed. Albuminuria was detected in 24.8% of patients under the age of 60 years, then in the older age categories it occurs in 35.1% of patients (P <0.01). This confirms that with age, renal dysfunction increases in patients with heart failure. Also, in the observed group of patients, the incidence of albuminuria was studied depending on hemoglobin parameters. Moreover, in groups of patients with low hemoglobin, albuminuria was detected in 35.6% of cases, in the absence of anemia, 24.3% (P <0.05). Considering that in the Republic of Uzbekistan blood creatinine indicators are often used to determine renal dysfunction, an analysis of its level depending on age, the presence of anemia and FC CHF has been carried out. Blood creatinine in patients under 60 years old was 74.9 17.7 and in 60 year olds and older 98 21.9 μmol / L.
A comparative analysis of this biochemical indicator, depending on the presence of anemia, revealed the following: with hemoglobin 112.43 12.0 g / l, creatinine was 119.64 13.7 μmol / l and with hemoglobin 134 9 g / l this indicator was equal to 89.6 8.5 μmol / L (P <0.01).

Key words: comorbidity, CHF, micralbuminuria, anemia, renal dysfunction.


 
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How to Cite this Article
Pubmed Style

Tosheva Khakima Bekmurodovna, Erkinova Nigora Erkinovna, Gadaev Abdigaffar Gadaevich, Djuraeva Nozima Oripovna, Khalilova Feruza Abduzhalolovna. Comorbid States in Patients with Chronic Heart Failure. Regional Level of the Problem (Preliminary Study). . 2020; 11(2): 59-65. doi:10.31838/jcdr.2020.11.02.11


Web Style

Tosheva Khakima Bekmurodovna, Erkinova Nigora Erkinovna, Gadaev Abdigaffar Gadaevich, Djuraeva Nozima Oripovna, Khalilova Feruza Abduzhalolovna. Comorbid States in Patients with Chronic Heart Failure. Regional Level of the Problem (Preliminary Study). http://www.jcdronline.org//?mno=118255 [Access: June 25, 2020]. doi:10.31838/jcdr.2020.11.02.11


AMA (American Medical Association) Style

Tosheva Khakima Bekmurodovna, Erkinova Nigora Erkinovna, Gadaev Abdigaffar Gadaevich, Djuraeva Nozima Oripovna, Khalilova Feruza Abduzhalolovna. Comorbid States in Patients with Chronic Heart Failure. Regional Level of the Problem (Preliminary Study). . 2020; 11(2): 59-65. doi:10.31838/jcdr.2020.11.02.11



Vancouver/ICMJE Style

Tosheva Khakima Bekmurodovna, Erkinova Nigora Erkinovna, Gadaev Abdigaffar Gadaevich, Djuraeva Nozima Oripovna, Khalilova Feruza Abduzhalolovna. Comorbid States in Patients with Chronic Heart Failure. Regional Level of the Problem (Preliminary Study). . (2020), [cited June 25, 2020]; 11(2): 59-65. doi:10.31838/jcdr.2020.11.02.11



Harvard Style

Tosheva Khakima Bekmurodovna, Erkinova Nigora Erkinovna, Gadaev Abdigaffar Gadaevich, Djuraeva Nozima Oripovna, Khalilova Feruza Abduzhalolovna (2020) Comorbid States in Patients with Chronic Heart Failure. Regional Level of the Problem (Preliminary Study). , 11 (2), 59-65. doi:10.31838/jcdr.2020.11.02.11



Turabian Style

Tosheva Khakima Bekmurodovna, Erkinova Nigora Erkinovna, Gadaev Abdigaffar Gadaevich, Djuraeva Nozima Oripovna, Khalilova Feruza Abduzhalolovna. 2020. Comorbid States in Patients with Chronic Heart Failure. Regional Level of the Problem (Preliminary Study). Journal of Cardiovascular Disease Research, 11 (2), 59-65. doi:10.31838/jcdr.2020.11.02.11



Chicago Style

Tosheva Khakima Bekmurodovna, Erkinova Nigora Erkinovna, Gadaev Abdigaffar Gadaevich, Djuraeva Nozima Oripovna, Khalilova Feruza Abduzhalolovna. "Comorbid States in Patients with Chronic Heart Failure. Regional Level of the Problem (Preliminary Study)." Journal of Cardiovascular Disease Research 11 (2020), 59-65. doi:10.31838/jcdr.2020.11.02.11



MLA (The Modern Language Association) Style

Tosheva Khakima Bekmurodovna, Erkinova Nigora Erkinovna, Gadaev Abdigaffar Gadaevich, Djuraeva Nozima Oripovna, Khalilova Feruza Abduzhalolovna. "Comorbid States in Patients with Chronic Heart Failure. Regional Level of the Problem (Preliminary Study)." Journal of Cardiovascular Disease Research 11.2 (2020), 59-65. Print. doi:10.31838/jcdr.2020.11.02.11



APA (American Psychological Association) Style

Tosheva Khakima Bekmurodovna, Erkinova Nigora Erkinovna, Gadaev Abdigaffar Gadaevich, Djuraeva Nozima Oripovna, Khalilova Feruza Abduzhalolovna (2020) Comorbid States in Patients with Chronic Heart Failure. Regional Level of the Problem (Preliminary Study). Journal of Cardiovascular Disease Research, 11 (2), 59-65. doi:10.31838/jcdr.2020.11.02.11