E-ISSN 0976-2833 | ISSN 0975-3583
 

Original Research (Original Article) 


Bilateral Breast Cancer: Clinical Presentation and Pathological Characteristics in Iraqi Patients

Bashar Mohammed Hobi, Nada A. S. Alwan.

Abstract
Background: Conflicting findings in the literature have been reported regarding the incidence and characteristics of bilateral breast cancer. Histologic lobular type of breast cancer in the index breast, having positive family history for breast cancer, diagnosis of first cancer at early age and BRCA genetic mutations are considered risk factors for developing bilateral breast cancer.

Aim of the study: To assess the demographic, clinical and pathological characters of bilateral breast cancer among a sample of Iraqi patients diagnosed with breast cancer.

Patients and Methods: This study is a descriptive retrospective comparative study which included 1161 patients histopathologically diagnosed to have breast cancer. Data was taken from clinical patients records as apart of competent information system data base developed by the National Cancer Research Center, Baghdad University in collaboration with the Referral Center for Early Detection of Breast Tumors, Medical City Teaching Hospital.

Results: Bilateral breast cancer constituted 4.4% of all breast cancer cases in the current study (51 cases out of 1162 cases). Significant differences were noted between Unilateral and Bilateral breast cancer patients with respect to patients age, family history of breast cancer, stage of the disease, histologic types and grade of the tumor (p<.0.05), Bilateral breast cancer was more common among patients with positive family history of breast cancer, who are under the age of 50 years and presented at more advanced stages than those with unilateral breast cancer. Invasive lobular carcinoma and well differentiated tumor grades were significantly more encountered among patients with bilateral breast cancer. On the other hand, there were no statistical differences between the two groups regarding marital status, history of lactation, hormonal intake, tumor size, lymph nodes involvement, skin changes, Estrogen, Progesterone and Her2/neu contents of the tumors.

Conclusion: Bilateral breast cancer tends to affect patients with positive family history of breast cancer, at younger ages and more advanced stages than those with Unilateral breast cancer. Invasive lobular carcinoma and well differentiated tumor grades were significantly more encountered among those with bilateral breast involvement. Careful identification of Iraqi patients with bilateral breast cancer through prompt diagnosis and early detection is mandatory to guide management protocols and ensure effective therapy.

Key words: Unilateral, bilateral, breast, cancer, clinical, pathological, Iraq.


 
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How to Cite this Article
Pubmed Style

Bashar Mohammed Hobi, Nada A. S. Alwan. Bilateral Breast Cancer: Clinical Presentation and Pathological Characteristics in Iraqi Patients. . 2020; 11(3): 111-116. doi:10.31838/jcdr.2020.11.03.26


Web Style

Bashar Mohammed Hobi, Nada A. S. Alwan. Bilateral Breast Cancer: Clinical Presentation and Pathological Characteristics in Iraqi Patients. http://www.jcdronline.org//?mno=119991 [Access: August 04, 2020]. doi:10.31838/jcdr.2020.11.03.26


AMA (American Medical Association) Style

Bashar Mohammed Hobi, Nada A. S. Alwan. Bilateral Breast Cancer: Clinical Presentation and Pathological Characteristics in Iraqi Patients. . 2020; 11(3): 111-116. doi:10.31838/jcdr.2020.11.03.26



Vancouver/ICMJE Style

Bashar Mohammed Hobi, Nada A. S. Alwan. Bilateral Breast Cancer: Clinical Presentation and Pathological Characteristics in Iraqi Patients. . (2020), [cited August 04, 2020]; 11(3): 111-116. doi:10.31838/jcdr.2020.11.03.26



Harvard Style

Bashar Mohammed Hobi, Nada A. S. Alwan (2020) Bilateral Breast Cancer: Clinical Presentation and Pathological Characteristics in Iraqi Patients. , 11 (3), 111-116. doi:10.31838/jcdr.2020.11.03.26



Turabian Style

Bashar Mohammed Hobi, Nada A. S. Alwan. 2020. Bilateral Breast Cancer: Clinical Presentation and Pathological Characteristics in Iraqi Patients. Journal of Cardiovascular Disease Research, 11 (3), 111-116. doi:10.31838/jcdr.2020.11.03.26



Chicago Style

Bashar Mohammed Hobi, Nada A. S. Alwan. "Bilateral Breast Cancer: Clinical Presentation and Pathological Characteristics in Iraqi Patients." Journal of Cardiovascular Disease Research 11 (2020), 111-116. doi:10.31838/jcdr.2020.11.03.26



MLA (The Modern Language Association) Style

Bashar Mohammed Hobi, Nada A. S. Alwan. "Bilateral Breast Cancer: Clinical Presentation and Pathological Characteristics in Iraqi Patients." Journal of Cardiovascular Disease Research 11.3 (2020), 111-116. Print. doi:10.31838/jcdr.2020.11.03.26



APA (American Psychological Association) Style

Bashar Mohammed Hobi, Nada A. S. Alwan (2020) Bilateral Breast Cancer: Clinical Presentation and Pathological Characteristics in Iraqi Patients. Journal of Cardiovascular Disease Research, 11 (3), 111-116. doi:10.31838/jcdr.2020.11.03.26





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