Abstract
The objective of study was detecting the phenolic compounds role in treatment of hyperlipidemia. 20 male rats were utilized and divided to the following groups; the first group was given standard pellet diet. The second group was administered (100mg/kg) triton for one time. The third group (rats with hyperlipidemia) was gaven (100ug/kg) phenolic compounds for 7 days. Fourth group (rats with hyperlipidemia) was gaven (10mg/kg) Simvastatin for 7 days. The outcomes exhibit significant (P < 0.05) elevated in levels ALT, and AST in triton and simvastatin groups compared with control group. While in fourth group show non-significant (P < 0.05) changes in levels ALT, and AST compare with control group. About the Hydroxymethylglutaryl-CoA (HMG-CoA) reductase and aorta diameter, exhibit significant (P < 0.05) elevated in triton group compared with control group. After treatment, HMG CoA reductase and aorta diameter exhibit non-significant (P < 0.05) changes in third and fourth groups compare with control group. It was concluded from current study that L. shawii phenolic compounds has been role in treatment of hyperlipidemia.

Key words: Phenolic Compounds, Hyperlipidemia, HMG-reductase, Liver Functions.