E-ISSN 0976-2833 | ISSN 0975-3583
 

Research Article 


Interferon Gamma and Mannose Binding Protein: Role in Susceptibility to Cytomegalovirus Infection

Shahad Abd Alrahman, Zainab A. Tolaifeh, Israa Adnan Ibraheam.

Abstract
Objectives: IFN- γ is a cytokine that is essential to the viral innate and adaptive immunity. MBL contributes to activation of the complement system lectin pathway in an antibody-independent mechanism. The polymorphisms in these genes have been reported in several diseases. To evaluate the impact of IFN-γ, MBL polymorphisms in Cytomegalovirus (CMV) Iraqi patients.

Material and Method: Fifty blood samples from CMV patients and healthy control group was collected, then DNA was extracted and analyzed for IFN-γ and MBL genotypes and Alleles frequencies with (PCR) and by Gel electrophoreses using 2.25% Agarose concentration (respectively) was examined.

Results: MBL mutations have been detected in 18% of CMV patients while only 4% in the control group, in addition mutant allele (B allele) has been detected in 14% in CMV patients and in 0% in the control group, when we compared with the control group, Genotype and allele frequency were found to have a significant association with the P<0.05 group of CMV infections. The TT genotype is associated with CMV viral clearance for IFN-α gene polymorphism.

Conclusion: MBL and IFN- γ Linked to cmv infection.

Key words: Health, Viral Clearance, Protein, Infections.


 
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How to Cite this Article
Pubmed Style

Shahad Abd Alrahman, Zainab A. Tolaifeh, Israa Adnan Ibraheam. Interferon Gamma and Mannose Binding Protein: Role in Susceptibility to Cytomegalovirus Infection. doi:10.31838/jcdr.2020.11.04.36


Web Style

Shahad Abd Alrahman, Zainab A. Tolaifeh, Israa Adnan Ibraheam. Interferon Gamma and Mannose Binding Protein: Role in Susceptibility to Cytomegalovirus Infection. http://www.jcdronline.org//?mno=17752 [Access: October 26, 2020]. doi:10.31838/jcdr.2020.11.04.36


AMA (American Medical Association) Style

Shahad Abd Alrahman, Zainab A. Tolaifeh, Israa Adnan Ibraheam. Interferon Gamma and Mannose Binding Protein: Role in Susceptibility to Cytomegalovirus Infection. doi:10.31838/jcdr.2020.11.04.36



Vancouver/ICMJE Style

Shahad Abd Alrahman, Zainab A. Tolaifeh, Israa Adnan Ibraheam. Interferon Gamma and Mannose Binding Protein: Role in Susceptibility to Cytomegalovirus Infection. doi:10.31838/jcdr.2020.11.04.36



Harvard Style

Shahad Abd Alrahman, Zainab A. Tolaifeh, Israa Adnan Ibraheam (2020) Interferon Gamma and Mannose Binding Protein: Role in Susceptibility to Cytomegalovirus Infection. doi:10.31838/jcdr.2020.11.04.36



Turabian Style

Shahad Abd Alrahman, Zainab A. Tolaifeh, Israa Adnan Ibraheam. 2020. Interferon Gamma and Mannose Binding Protein: Role in Susceptibility to Cytomegalovirus Infection. doi:10.31838/jcdr.2020.11.04.36



Chicago Style

Shahad Abd Alrahman, Zainab A. Tolaifeh, Israa Adnan Ibraheam. "Interferon Gamma and Mannose Binding Protein: Role in Susceptibility to Cytomegalovirus Infection." doi:10.31838/jcdr.2020.11.04.36



MLA (The Modern Language Association) Style

Shahad Abd Alrahman, Zainab A. Tolaifeh, Israa Adnan Ibraheam. "Interferon Gamma and Mannose Binding Protein: Role in Susceptibility to Cytomegalovirus Infection." doi:10.31838/jcdr.2020.11.04.36



APA (American Psychological Association) Style

Shahad Abd Alrahman, Zainab A. Tolaifeh, Israa Adnan Ibraheam (2020) Interferon Gamma and Mannose Binding Protein: Role in Susceptibility to Cytomegalovirus Infection. doi:10.31838/jcdr.2020.11.04.36





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