E-ISSN 0976-2833 | ISSN 0975-3583
 

Review Article 


P2Y receptors as regulators of lung endothelial barrier integrity

Evgeny Zemskov, Rudolf Lucas Alexander D. Verin, Nagavedi S. Umapathy.

Abstract
Endothelial cells (ECs), forming a semi-permeable barrier between the interior space of blood vessels and
underlying tissues, control such diverse processes as vascular tone, homeostasis, adhesion of platelets, and
leukocytes to the vascular wall and permeability of vascular wall for cells and fluids. Mechanisms which
govern the highly clinically relevant process of increased EC permeability are under intense investigation. It
is well known that loss of this barrier (permeability increase) results in tissue inflammation, the hall mark of
inflammatory diseases such as acute lung injury and its severe form, acute respiratory distress syndrome. Little is
known about processes which determine the endothelial barrier enhancement or protection against permeability
increase. It is now well accepted that extracellular purines and pyrimidines are promising and physiologically
relevant barrier-protective agents and their effects are mediated by interaction with cell surface P2Y receptors
which belong to the superfamily of G-protein-coupled receptors. The therapeutic potential of P2Y receptors
is rapidly expanding field in pharmacology and some selective agonists became recently available. Here, we
present an overview of recently identified P2Y receptor agonists that enhance the pulmonary endothelial barrier
and inhibit and/or reverse endothelial barrier disruption.

Key words: EPAC, lipopolysaccharide, microvascular endothelium, MLC-phosphatase, permeability, VE-cadherin


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Evgeny Zemskov
Articles by Rudolf Lucas Alexander D. Verin
Articles by Nagavedi S. Umapathy
on Google
on Google Scholar
Article Statistics
 Viewed: 1
Downloaded: 0


How to Cite this Article
Pubmed Style

Evgeny Zemskov, Rudolf Lucas Alexander D. Verin, Nagavedi S. Umapathy. P2Y receptors as regulators of lung endothelial barrier integrity. . 2011; 2(1): 14-22. doi:10.4103/0975-3583.78582


Web Style

Evgeny Zemskov, Rudolf Lucas Alexander D. Verin, Nagavedi S. Umapathy. P2Y receptors as regulators of lung endothelial barrier integrity. http://www.jcdronline.org//?mno=93000 [Access: March 23, 2020]. doi:10.4103/0975-3583.78582


AMA (American Medical Association) Style

Evgeny Zemskov, Rudolf Lucas Alexander D. Verin, Nagavedi S. Umapathy. P2Y receptors as regulators of lung endothelial barrier integrity. . 2011; 2(1): 14-22. doi:10.4103/0975-3583.78582



Vancouver/ICMJE Style

Evgeny Zemskov, Rudolf Lucas Alexander D. Verin, Nagavedi S. Umapathy. P2Y receptors as regulators of lung endothelial barrier integrity. . (2011), [cited March 23, 2020]; 2(1): 14-22. doi:10.4103/0975-3583.78582



Harvard Style

Evgeny Zemskov, Rudolf Lucas Alexander D. Verin, Nagavedi S. Umapathy (2011) P2Y receptors as regulators of lung endothelial barrier integrity. , 2 (1), 14-22. doi:10.4103/0975-3583.78582



Turabian Style

Evgeny Zemskov, Rudolf Lucas Alexander D. Verin, Nagavedi S. Umapathy. 2011. P2Y receptors as regulators of lung endothelial barrier integrity. Journal of Cardiovascular Disease Research, 2 (1), 14-22. doi:10.4103/0975-3583.78582



Chicago Style

Evgeny Zemskov, Rudolf Lucas Alexander D. Verin, Nagavedi S. Umapathy. "P2Y receptors as regulators of lung endothelial barrier integrity." Journal of Cardiovascular Disease Research 2 (2011), 14-22. doi:10.4103/0975-3583.78582



MLA (The Modern Language Association) Style

Evgeny Zemskov, Rudolf Lucas Alexander D. Verin, Nagavedi S. Umapathy. "P2Y receptors as regulators of lung endothelial barrier integrity." Journal of Cardiovascular Disease Research 2.1 (2011), 14-22. Print. doi:10.4103/0975-3583.78582



APA (American Psychological Association) Style

Evgeny Zemskov, Rudolf Lucas Alexander D. Verin, Nagavedi S. Umapathy (2011) P2Y receptors as regulators of lung endothelial barrier integrity. Journal of Cardiovascular Disease Research, 2 (1), 14-22. doi:10.4103/0975-3583.78582





Most Viewed Articles
  • Reduced nitrate level in individuals with hypertension and diabetes
    Shiekh Gazalla Ayub, Taha Ayub, Saquib Naveed Khan, Rubiya Dar, Khurshid Iqbal Andrabi
    . 2011; 2(3): 172-176
    » Abstract » doi: 10.4103/0975-3583.85264

  • Association of statin therapy with blood pressure control in hypertensive hypercholesterolemic outpatients in clinical practice
    Manuel Morgado, Sandra Rolo, Ana Filipa Macedo, Miguel Castelo-Branco
    . 2011; 2(1): 44-49
    » Abstract » doi: 10.4103/0975-3583.78596

  • Abdominal obesity, an independent cardiovascular risk factor in Indian subcontinent: A clinico epidemiological evidence summary
    D. S. Prasad, Zubair Kabir , A. K. Dash, B. C. Das
    . 2011; 2(4): 199-205
    » Abstract » doi: 10.4103/0975-3583.89803

  • Utilization of Real-time 3D Transesophageal Echocardiography in an Urban Academic Medical Center
    Lili Zhang, Elaine Y. Lin, Dron Bhandari, Mohan Pamerla, George K. Lui, Cynthia C. Taub
    . 2014; 5(2): 9-14
    » Abstract » doi: 10.5530/jcdr.2014.2.3

  • High prevalence of cardiovascular diseases among other medically compromised conditions in dental patients: A retrospective study
    Sumit Bhateja
    . 2012; 3(2): 113-116
    » Abstract » doi: 10.4103/0975-3583.95364

  • Most Downloaded
  • Review Article: Impact of Ivabradine on Cardiovascular Morbidity
    Gammone M, Riccioni G, D’Orazio
    . 2020; 11(1): 4-8
    » Abstract » doi: 10.5530/jcdr.2020.11.02

  • Vascular Endothelial Growth Factor and its Soluble Receptor-1 as Surrogate Markers for Subjects with High-risk of Cardiovascular Disease
    Vipa Boonkitticharoen, Chanika Sritara, Prin Vathesatogkit, Supakajee Saengruang-Orn,Wipa Ratanachaiwong, Piyamitr Sritara
    . 2014; 5(2): 35-42
    » Abstract » doi: 10.5530/jcdr.2014.2.8

  • Study of Metabolic Syndrome and Its Components Among Kurnool District Population of Andhra Pradesh with Different Ethnic Backgrounds
    Pandit Vinodh Bandela, Nilima Nandakumar Dongre, Jeevan Gangadhar Ambekar, Kedam Durga Prasad, Basavaraj B Devaranavadagi
    . 2017; 8(3): 83-88
    » Abstract » doi: 10.5530jcdr.2017.3.20

  • Diagnosis and surgical treatment of carotid body tumor: A report of 18 cases
    Dan Ma, Min Liu, Hua Yang, Xiaogan Ma, Chaojun Zhang
    . 2010; 1(3): 122-124
    » Abstract » doi: 10.4103/0975-3583.70905

  • P2Y receptors as regulators of lung endothelial barrier integrity
    Evgeny Zemskov, Rudolf Lucas Alexander D. Verin, Nagavedi S. Umapathy
    . 2011; 2(1): 14-22
    » Abstract » doi: 10.4103/0975-3583.78582

  • Most Cited Articles