E-ISSN 0976-2833 | ISSN 0975-3583
 

Original Research (Original Article) 


Plasma asymmetric dimethylarginine and l-arginine levels in Chinese patients with essential hypertension without coronary artery disease

Hongju Wang, Jun Liu.

Abstract
Objective: To investigate the plasma asymmetric dimethylarginine (ADMA) levels and l-arginine in the essential
hypertension (EH) patients without coronary artery disease. Patients and Methods: A total of 86 Chinese
patients were enrolled in this study. All patients received coronary multidetector-row computed tomography
to exclude distinct coronary stenosis and treadmill exercise testing to exclude microvascular angina pectoris.
The patients with normal blood pressure (n = 26) were set as the control group. The EH patients were divided
into three subgroups: the prehypertension group (n = 26), the stage 1 hypertension group (n = 26) and the stage
2 hypertension group (n = 8). The plasma ADMA and l-arginine concentrations were measured by a validated
high-throughput liquid chromatographic tandem mass spectrometric assay. Results: There was a significantly
higher ADMA level [0.028 (0.016) mmol/L vs. 0.021 (0.010) mmol/L, P = 0.002] and lower l-arginine to ADMA
ratio [1.42 (0.58) vs. 2.01 (0.99), P < 0.001] in the EH group compared with the control group. Among the EH
patients, the ADMA levels were increased by grades of hypertension [0.028 (0.011) mmol/L, 0.027 (0.014)
mmol/L, 0.035 (0.024) mmol/L, respectively, P < 0.001]. The ADMA level was independently related to the
systolic blood pressure (r = 1.047, P = 0.001). Conclusion: The plasma ADMA levels were significantly elevated
with grades of hypertension in EH patients and were positively related to the systolic blood pressure levels.

Key words: Asymmetric dimethylarginine, essential hypertension, l-arginine


 
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How to Cite this Article
Pubmed Style

Hongju Wang, Jun Liu. Plasma asymmetric dimethylarginine and l-arginine levels in Chinese patients with essential hypertension without coronary artery disease. . 2011; 2(3): 177-180. doi:10.4103/0975-3583.85265


Web Style

Hongju Wang, Jun Liu. Plasma asymmetric dimethylarginine and l-arginine levels in Chinese patients with essential hypertension without coronary artery disease. http://www.jcdronline.org//?mno=93181 [Access: March 27, 2020]. doi:10.4103/0975-3583.85265


AMA (American Medical Association) Style

Hongju Wang, Jun Liu. Plasma asymmetric dimethylarginine and l-arginine levels in Chinese patients with essential hypertension without coronary artery disease. . 2011; 2(3): 177-180. doi:10.4103/0975-3583.85265



Vancouver/ICMJE Style

Hongju Wang, Jun Liu. Plasma asymmetric dimethylarginine and l-arginine levels in Chinese patients with essential hypertension without coronary artery disease. . (2011), [cited March 27, 2020]; 2(3): 177-180. doi:10.4103/0975-3583.85265



Harvard Style

Hongju Wang, Jun Liu (2011) Plasma asymmetric dimethylarginine and l-arginine levels in Chinese patients with essential hypertension without coronary artery disease. , 2 (3), 177-180. doi:10.4103/0975-3583.85265



Turabian Style

Hongju Wang, Jun Liu. 2011. Plasma asymmetric dimethylarginine and l-arginine levels in Chinese patients with essential hypertension without coronary artery disease. Journal of Cardiovascular Disease Research, 2 (3), 177-180. doi:10.4103/0975-3583.85265



Chicago Style

Hongju Wang, Jun Liu. "Plasma asymmetric dimethylarginine and l-arginine levels in Chinese patients with essential hypertension without coronary artery disease." Journal of Cardiovascular Disease Research 2 (2011), 177-180. doi:10.4103/0975-3583.85265



MLA (The Modern Language Association) Style

Hongju Wang, Jun Liu. "Plasma asymmetric dimethylarginine and l-arginine levels in Chinese patients with essential hypertension without coronary artery disease." Journal of Cardiovascular Disease Research 2.3 (2011), 177-180. Print. doi:10.4103/0975-3583.85265



APA (American Psychological Association) Style

Hongju Wang, Jun Liu (2011) Plasma asymmetric dimethylarginine and l-arginine levels in Chinese patients with essential hypertension without coronary artery disease. Journal of Cardiovascular Disease Research, 2 (3), 177-180. doi:10.4103/0975-3583.85265





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