E-ISSN 0976-2833 | ISSN 0975-3583
 

Original Research (Original Article) 


Vascular Inflammation and Angiographic Severity of Coronary Artery Disease in Young Asian Indians

Imran Ahmed, Achyut Sarkar, Arindam Pande, Naveen Chandra GS, Shailesh Patil,Chanchal Kundu.

Abstract
Background: By 2015, India will have the largest coronary artery disease (CAD) burden in the world. Indians manifest
CAD at a younger age. Inflammation plays a key role in CAD progression. Inflammatory marker high sensitivity
C-reactive protein (hsCRP) predicts CAD risk either by correlation with CAD extent (disease marker) or as an indicator
of inflammatory event that leads to plaque rupture (a process marker). Aim: To assess the role of vascular inflammation
and correlate with coronary atherosclerosis in an economically and relevant section of population of young Indians.
Methods: Serum hs-CRP (measured by immune-turbidimetry technique) level was measured in young adults (18–45
years) with angiographic proven CAD (60 patients), and compared with those >45 years age (24 patients), and in controls
with no CAD (14 patients).Later, the levels of hs-CRP were compared with the angiographic stenosis and extent score in
young CAD patients. Results: Mean hsCRP was elevated in Young CAD patients more than in those of Old CAD patients
and Controls, and this trend was found to be significant by ANOVA (P = 0.028).The hs-CRP levels were found to be in
direct proportion to both stenosis and extent score of coronary artery disease (P <0.01) in young adults. Conclusion:
Serum hs-CRP levels and inflammation have a positive correlation with the disease burden in the young CAD patient.
Premature CAD in Young Asian Indians could be partly explained by increased vascular inflammation. Further studies
and interventions to identify & reduce risk factors in an economically and socially relevant section of population of a fast
developing country like India is urgently needed.

Key words: Angiographic stenosis, Angiographic extent, hs-CRP, Young coronary artery disease


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Imran Ahmed
Articles by Achyut Sarkar
Articles by Arindam Pande
Articles by Naveen Chandra GS
Articles by Shailesh Patil
Articles by Chanchal Kundu
on Google
on Google Scholar
Article Statistics
 Viewed: 1
Downloaded: 1


How to Cite this Article
Pubmed Style

Imran Ahmed, Achyut Sarkar, Arindam Pande, Naveen Chandra GS, Shailesh Patil,Chanchal Kundu. Vascular Inflammation and Angiographic Severity of Coronary Artery Disease in Young Asian Indians. . 2014; 5(1): 15-21. doi:10.5530/jcdr.2014.1.3


Web Style

Imran Ahmed, Achyut Sarkar, Arindam Pande, Naveen Chandra GS, Shailesh Patil,Chanchal Kundu. Vascular Inflammation and Angiographic Severity of Coronary Artery Disease in Young Asian Indians. http://www.jcdronline.org//?mno=93433 [Access: March 24, 2020]. doi:10.5530/jcdr.2014.1.3


AMA (American Medical Association) Style

Imran Ahmed, Achyut Sarkar, Arindam Pande, Naveen Chandra GS, Shailesh Patil,Chanchal Kundu. Vascular Inflammation and Angiographic Severity of Coronary Artery Disease in Young Asian Indians. . 2014; 5(1): 15-21. doi:10.5530/jcdr.2014.1.3



Vancouver/ICMJE Style

Imran Ahmed, Achyut Sarkar, Arindam Pande, Naveen Chandra GS, Shailesh Patil,Chanchal Kundu. Vascular Inflammation and Angiographic Severity of Coronary Artery Disease in Young Asian Indians. . (2014), [cited March 24, 2020]; 5(1): 15-21. doi:10.5530/jcdr.2014.1.3



Harvard Style

Imran Ahmed, Achyut Sarkar, Arindam Pande, Naveen Chandra GS, Shailesh Patil,Chanchal Kundu (2014) Vascular Inflammation and Angiographic Severity of Coronary Artery Disease in Young Asian Indians. , 5 (1), 15-21. doi:10.5530/jcdr.2014.1.3



Turabian Style

Imran Ahmed, Achyut Sarkar, Arindam Pande, Naveen Chandra GS, Shailesh Patil,Chanchal Kundu. 2014. Vascular Inflammation and Angiographic Severity of Coronary Artery Disease in Young Asian Indians. Journal of Cardiovascular Disease Research, 5 (1), 15-21. doi:10.5530/jcdr.2014.1.3



Chicago Style

Imran Ahmed, Achyut Sarkar, Arindam Pande, Naveen Chandra GS, Shailesh Patil,Chanchal Kundu. "Vascular Inflammation and Angiographic Severity of Coronary Artery Disease in Young Asian Indians." Journal of Cardiovascular Disease Research 5 (2014), 15-21. doi:10.5530/jcdr.2014.1.3



MLA (The Modern Language Association) Style

Imran Ahmed, Achyut Sarkar, Arindam Pande, Naveen Chandra GS, Shailesh Patil,Chanchal Kundu. "Vascular Inflammation and Angiographic Severity of Coronary Artery Disease in Young Asian Indians." Journal of Cardiovascular Disease Research 5.1 (2014), 15-21. Print. doi:10.5530/jcdr.2014.1.3



APA (American Psychological Association) Style

Imran Ahmed, Achyut Sarkar, Arindam Pande, Naveen Chandra GS, Shailesh Patil,Chanchal Kundu (2014) Vascular Inflammation and Angiographic Severity of Coronary Artery Disease in Young Asian Indians. Journal of Cardiovascular Disease Research, 5 (1), 15-21. doi:10.5530/jcdr.2014.1.3





Most Viewed Articles
  • Reduced nitrate level in individuals with hypertension and diabetes
    Shiekh Gazalla Ayub, Taha Ayub, Saquib Naveed Khan, Rubiya Dar, Khurshid Iqbal Andrabi
    . 2011; 2(3): 172-176
    » Abstract » doi: 10.4103/0975-3583.85264

  • Factor analysis of risk variables associated with metabolic syndrome in adult Asian Indians
    Mithun Das, Susil Pal, Arnab Ghosh
    . 2010; 1(2): 86-91
    » Abstract » doi: 10.4103/0975-3583.64442

  • Association of statin therapy with blood pressure control in hypertensive hypercholesterolemic outpatients in clinical practice
    Manuel Morgado, Sandra Rolo, Ana Filipa Macedo, Miguel Castelo-Branco
    . 2011; 2(1): 44-49
    » Abstract » doi: 10.4103/0975-3583.78596

  • Abdominal obesity, an independent cardiovascular risk factor in Indian subcontinent: A clinico epidemiological evidence summary
    D. S. Prasad, Zubair Kabir , A. K. Dash, B. C. Das
    . 2011; 2(4): 199-205
    » Abstract » doi: 10.4103/0975-3583.89803

  • Utilization of Real-time 3D Transesophageal Echocardiography in an Urban Academic Medical Center
    Lili Zhang, Elaine Y. Lin, Dron Bhandari, Mohan Pamerla, George K. Lui, Cynthia C. Taub
    . 2014; 5(2): 9-14
    » Abstract » doi: 10.5530/jcdr.2014.2.3

  • Most Downloaded
  • Sildenafil Improves Right Ventricular Function, Exercise Capacity, and Quality of Life in Patients with Biventricular Dysfunction: Results from a Randomised Study
    Vikas K, Saurabh Mehrotra, Ashwani Sood, Yashpaul Sharma
    . 2020; 11(3): 85-89
    » Abstract » doi: 10.31838/jcdr.2020.11.03.20

  • Evaluation of the RV function in ASD patients pre and post transcatheter occlusion by speckle tracking
    Ghazi Farhan Haji, Venus Abdulwahid Alwan, Sa`ad Hashim Mohammed
    . 2020; 11(1): 24-30
    » Abstract » doi: 10.31838/jcdr.2020.11.01.07

  • Review Article: Impact of Ivabradine on Cardiovascular Morbidity
    Gammone M, Riccioni G, D’Orazio
    . 2020; 11(1): 4-8
    » Abstract » doi: 10.5530/jcdr.2020.11.02

  • The Role of D-Dimer in the Diagnosis of Left Atrial Appendage Thrombus in Patients with Atrial Fibrillation
    Samir Rafla, Tarek Beshay
    . 2020; 11(3): 117-123
    » Abstract » doi: 10.31838/jcdr.2020.11.03.27

  • Vascular Inflammation and Angiographic Severity of Coronary Artery Disease in Young Asian Indians
    Imran Ahmed, Achyut Sarkar, Arindam Pande, Naveen Chandra GS, Shailesh Patil,Chanchal Kundu
    . 2014; 5(1): 15-21
    » Abstract » doi: 10.5530/jcdr.2014.1.3

  • Most Cited Articles