Background: Diabetes is the chronic disorder resulting from a number of factors in which an absolute or relative defi ciency of insulin or its function occurs. It has emerged as a major public health problem in India. The risk of coronary artery disease (CAD) among Indian diabetic population is 2-4 times higher than that of non-diabetic subjects. The infl ammatory markers such as C-reactive proteins (CRPs), fi brinogen, interleukin-4, homocysteine have been recognized as an independent risk factor for CAD. Aim: The aim was to evaluate the infl ammatory markers for early detection of CAD in diabetics. Materials and Methods: In the present study, 50 diabetic patients (both sexes) with raised glycosylated hemoglobin in the age range of 50-65 years and equal number of age and gender matched normal healthy subjects (control) were recruited. The levels of plasma CRP, fi brinogen, homocysteine along with various lipoproteins were evaluated in uncontrolled diabetic patients. Results: The levels of total cholesterol, triglycerides, very-low-density lipoprotein (LDL)-cholesterol and LDL-cholesterol signifi cantly increased while high-density lipoprotein-cholesterol levels were signifi cantly decreased in serum of diabetic patients in comparison to normal healthy control subjects. A signifi cant increase in the CRP (P < 0.001), fi brinogen (P < 0.001), and homocysteine (P < 0.01) levels in diabetic patients with respect to control subjects was observed. Conclusion: This study therefore suggests the importance of assessing infl ammatory markers along with other routine investigations in diabetic patients in addition to primary and secondary preventives measures to migrate the devastating consequences of diabetes leading to CAD. This strategy may help to identify and monitor high-risk diabetic for any cardiovascular event thereby reducing the economic burden and improving the quality of life.