02903nas a2200217 4500008004100000245011600041210006900157260001500226300001000241490000600251520221100257653001802468653002302486653001802509653002302527100001802550700001902568700001902587700001902606856006002625 2018 eng d00aIs Cardiovascular Risk Associated with Subclinical Hypothyroidism: Role of C Reactive Protein and Interleukin-60 aCardiovascular Risk Associated with Subclinical Hypothyroidism R cMarch 2018 a20-230 v93 a

Background: Subclinical hypothyroidism causes development of cardiovascular risk is not very well defined due to contradictory findings over the years. Role of inflammatory markers in Subclinical hypothyroidism is not very well studied in the past. Objective: The main objective of this study was to assessment of the role of interleukin-6 and C reactive protein in subclinical hypothyroidism patients having TSH <10μIU/ml. Material and Method: Total 90 young adult males from 20-40 years age group were recruited for the study in which 60 males were with recently diagnosed subclinical hypothyroidism and remaining 30 males were healthy controls. Subclinical hypothyroidism was diagnosed by measuring TSH and FT4, which were estimated by enzyme linked immunosorbent assay (ELISA). Total cholesterol, triglycerides, and High Density Lipoprotein-cholesterol were estimated by spectrophotometric method. Friedewald formula was used for the estimation of Low Density Lipoprotein cholesterol. Lipoprotein ratios (total cholesterol/HDL-cholesterol and LDL-Cholesterol/ HDL-cholesterol) were also estimated. C reactive protein and interleukin-6 were also estimated by ELISA. Results: Significant results were obtained among the various parameters between the groups. Thyroid stimulating hormone was significantly (<0.001) different between patients and control group. In subclinical hypothyroidism patients total cholesterol, triglycerides and LDL cholesterol were significantly higher (<0.01). HDL cholesterol was significantly (<0.001) lower in the patient group. Lipoprotein ratios were also highly significant (<0.001) between the groups and concentrations were higher in the patient group. C reactive protein and interleukin-6 were highly significant (<0.001) between the groups. Conclusion: Subclinical hypothyroidism patients having TSH<10μIU/ml are characterized by the atherogenic lipid profile. Increased concentration of interleukin-6 along with higher concentration of C reactive protein might be the sign of early risk of atherogenic risk progression.

10aAtherogenesis10aC reactive protein10aInterleukin-610aLipoprotein ratios1 aGupta, Gaurav1 aSharma, Preeti1 aKumar, Pradeep1 aSharma, Rachna uhttp://jcdronline.org/article/2018/9/1/105530jcdr201815 ?> ?>