Histopathologic Spectrum of Adult Renal Epithelial Tumors in a Tertiary Care Hospital in India

Abstract

40 cases of adult renal epithelial neoplasms received at Saifee Hospital, Mumbai for a period of 3 years were evaluated for various gross and microscopic features. Demographic details and histopathologic prognostic determinants were studied for all the cases. All 40 cases studied were malignant neoplasms. A male predominance (3:1) and predilection for left kidney (60%) were observed. Majority of the cases were between 41-70 years age. Conventional clear cell RCC was the commonest histologic subtype (67.5%), followed by Papillary RCC (17.5%) and Chromophobe RCC (10%). Only one case of Multilocular cystic RCC and one very rare case of unilateral synchronous clear cell RCC with papillary RCC were encountered. Furhman nuclear grade 2 was the commonest (60%), followed by grade 3 (27.5%) and grade 4 (12.5%). Necrosis was identified on microscopy in 50% cases and 5% cases showed sarcomatoid features. Lymphovascular invasion was present in 12.5% cases and Hilar lymph node metastases in 10% cases.