Development and Characterization of Allicin Alginate Beads for Stomach-Specific Delivery

Abstract

One of the most common symptoms connected with gastrointestinal illnesses is gastric irritation. The current study sought to develop floating calcium alginate beads of Allicin for targeting the stomach mucosa and extending their gastric residency period. Allicin is the oily, yellow substance that gives garlic its unique odour. It is a sulfenic acid thioester. Alyl thiosulfinate is
another name for it. Its biological activity is due to its antioxidant activity as well as its reactivity with thiol-containing proteins. Allicin was suspended in calcium alginate solution to make the beads. The beads were made with calcium alginate and Allicin (1:1) and tested. The average diameter, drug loading, and entrapment efficiency were all measured. Thus, the present
investigation aimed in formulating stomach specific drug delivery useful in the treatment of gastric problems.