Acute soft head syndrome –A rare complication of sickle cell disease

Abstract

Acute soft head syndrome is a rare complication of sickle cell disease. This case report describes 
an 18-year-old male with sickle cell disease who presented with right-sided periorbital and scalp 
swelling, indicative of acute soft head syndrome, one of the rarest complications of this 
condition. The patient was treated without aspiration of the scalp swelling, highlighting that 
acute soft head syndrome should be considered a differential diagnosis for scalp pain and 
swelling in sickle cell disease patients