Role of Asp299Gly single nucleotide polymorphism of TLR4 gene in susceptibility of idiopathic dilated cardiomyopathy

Abstract

Introduction: cardiovascular diseases remain one of the major reasons of universal mortality and accounts for 31% of deaths alone in India. Cardiomyopathy is one such cardiovascular anarchy that is linked with heterogenous aetiologies leading to ventricular hypertrophy and myocardial dysfunction. Between 2008-2015, owing to cardiomyopathies there has been significant increase in evidences of hospitalisation for heart failure, mechanical circulatory supports, defibrillators implantations and 51% of all heart transplants [Lannou Set al, 2020].