The Prediction of the Bisoprolol Effectiveness in Patients with Stable Coronary Artery Disease with PostInfarction Cardiosclerosis

Authors

  • Svetlana S. Bunova, Ol'ga V. Zamahina, Nikolaj A. Nikolaev, Nina I.Zhernakova, Andrey A.Grishchenko Author

DOI:

https://doi.org/10.48047/

Keywords:

heart rate, stable coronary artery disease, post-infarction cardiosclerosis, heart rate variability, Arg389Gly polymorphism of the ADRB1 gene.

Abstract

The article shows the benefits of treatment with bisoprolol in achieving optimal heart rate at rest (55-60 per 1 minute) and identifies the prediction markers of its achievement in patients with stable coronary artery disease with post-infarction cardiosclerosis, taking into account clinical and genetic data: physical examination, 24-hour ECG monitoring, 5-minute study of heart rate variability, Arg389Gly polymorphism of the ADRB1 gene. The article proved that when a heart rate of 55-60 in
1 minute is reached, the antianginal effect of bisoprolol is expressed better, the markers of the prognosis in the achievement of this heart rate are determined. 

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Published

2020-10-24

Issue

Vol. 11 No. 4 (2020): volume 11 issue 4 (2020)

Section

Articles