Exploration of Cytokines Storm by Detect Cytokines Level among Sera of in Patients with COVID 19 at ThiQar Provence -Iraq

Abstract

(SARS-CoV 2) is a complex viral infection disease with a strong patho immune- physiological reaction contribution to its pathogenesis. Genetic with environment factors account for the majority of population susceptibility to this disease. This study is carried out to evaluate some immunogenic and molecular parameters such cytokines in some Iraqi patients with (SARS-CoV2) and detect the association of immune status and severity of disease. The study included 100 patients with COVID 19. And 30 apparently healthy individuals (as control).When some cytokines (IL-1 alpha, GM-CSF, IL-8, IL-6 and IL-2 receptor) have been measured in the sera of the studied groups. All these cytokines have revealed a highly significant elevation when detected among SARS-CoV2 in comparison with healthy control group, except GM-CSF has showed a significant elevation in SARS-CoV2 patients only. This results goes to establish growth (cytokines storm) which its drive to understand the develop molecular immune pattern as key step is to speedily ramp up research related to the production of an effective vaccine for the SARS-CoV2 respiratory syndrome.