The Impact of MBL-2 and HLA-G Insertion/Deletion Gene Polymorphism in Vulvovaginal Candidiasis in Iraqi Patients Women

Abstract

Objectives: MBL (Mannose-binding lectin) is a protein made predominantly inside of the liver, which linked mannose, N-acetyl glucosamine, and focus residues on the cell walls of the microorganism. We saw that the polymorphisms of (MBL2 gene) affect host sensitivity to Candida infection. Human leucocyte antigen-G (HLA-G) are an insertion/deletion polymorphism play a role as immunotolerance, stimulate apoptosis of activated CD8+ T cells, interactions with the (T regulatory cells), modification of the action of dendritic cells and natural killer cells. The polymorphisms in these genes have been reported in several diseases. To evaluate the impact of MBL-2, HLA-G (Ins/Del) polymorphisms in Vulvovaginal candidiasis (VVC) Iraqi patients women.