Evaluation of VDR Gene Polymorphisms with Nephropathy Stages in Men with Type 2 Diabetes Mellitus

Abstract

To appraise the association of VDR FokI and TaqI polymorphisms with diabetic nephropathy patients, a total of 60 men with type 2 diabetes mellitus (T2DM) were enrolled in the recent paper, as well as 17 healthy men as a control. The patients have been divided according to the albumin/creatinine ratio (Normo albuminuria, micro-albuminuria, and macro-albuminuria,). ARMS PCR was used to diagnose the genotypes and allele frequencies of FokI "rs10735810*" and TaqI "rs731236*". The results
indicated that FF, Ff and TT, Tt genotype were significantly higher in patients with T2DM than the control (OD=3.375, p=0.001), (OD=4.333, p=0.001), (OD=4.222, p=0.001), and (OD=2.833, p=0.025) respectively