Comparative analysis of Ibuprofen tablets by UV Visible Spectroscopy & FTIR
DOI:
https://doi.org/10.48047/Keywords:
Ibuprofen, UV spectrophotometry, phosphate buffer, Disintegration, Dissolution.Abstract
To assess the integrity and excellence of various makes of Ibuprofen tablets, ultraviolet (UV) spectrophotometry and Fouriertransform infrared (FTIR) spectroscopy are employed. Simultaneously, a straightforward, economical, and responsive
spectrophotometric approach is established to ascertain the composition of Ibuprofen tablets accessible in the local market.
Furthermore, both externally available and internally produced tablets undergo evaluation via UV spectrophotometry and FTIR
spectroscopy. UV spectrophotometry centers on gauging the absorbance at the predominant wavelength of 223 nm using a
phosphate buffer solution. The tablets' overall purity is gauged by matching them with the criteria established by the United States Pharmacopoeia (USP) and the British Pharmacopoeia (BP). In the case of FTIR spectroscopy, the spectra of commercial and inhouse Ibuprofen tablets are scrutinized and juxtaposed. While both marketed and in-house tablets conform to the weight uniformity specification, FTIR spectroscopy emerges as a more precise and sensitive method, producing more favorable outcomes compared to UV spectrophotometry. The eminence and safety of pharmaceutical products are of utmost significance.
