TOLERABILITY AND EFFICACY OF FIXED DOSE COMBINATION OF NORTRIPTYLINE AND PREGABALIN IN MANAGING PERIPHERAL NEUROPATHY IN DIABETICS

Abstract

Background: Treating diabetic peripheral neuropathy (DPN) is a challenging condition with the 
non-availability of effective therapies for many subjects making pharmacotherapy development 
vital. Combined use of Nortriptyline and pregabalin can result in complementary and enhancing 
effects through various mechanisms reducing the disease symptoms. However, existing literature 
data supporting this combination are limited.