A Study of insulin resistance in cases of Chronic kidney disease with or without hemodialysis on comparison with normal individuals

Abstract

In Diabetes Mellitus & Metabolic Syndrome IR is  related to innate immunity & inflammation is related to insulin 
sensitivity and energy metabolism. 1-2Recent advances indicate involvement  of gut microbiota &  Uraemia Retention Molecules (URMs) in CKD.3-5  In Uraemia , Endogenous production of specific factors are involved in insulin signaling pathways in CKD.6-7 White adipose tissue is a source of specific molecules in the causation of metabolic disturbances (IR) in CKD 8 which leads to  impairment of insulin signalling through inhibitory serine phosphorylation of insulin 
receptor substrate (IRS).IR leads to impairment of ins