Analysis of the HPA (hypothalamic pituitary adrenal) axis perioperatively in patients who underwent transsphenoidal surgery for pituitary adenomas with a normal preoperative HPA axis

Abstract

Background: To observe the changes in the HPA axis postoperatively in those patients who 
underwent trans-sphenoidal excision of the pituitary adenomas with a normal preoperative HPA 
axis. Settings and Design: 61 patients presenting with pituitary adenomas with a preoperative 
normal HPA axis were chosen and were not given the routine perioperative steroid cover and 
their serum cortisol levels were assessed after undergoing transsphenoidal surgery with 
intraoperative preservation of the normal gland.