Combined CDX2 Expression and TIL Density as a Prognostic Indicator in Adjuvant FOLFOX-Treated Stage III Colorectal Cancer.

Abstract

Background: Colorectal carcinomas (CRCs) with caudal-type homeobox 2 (CDX2) loss are 
associated with aggressive behavior but often exhibit high densities of tumor-infiltrating 
lymphocytes (TILs). The interplay between CDX2 loss and TIL density in CRC patient 
survival remains unclear. 
Methods: Stage III CRC tissues were assessed for CDX2 loss by immunohistochemistry. 
CD8 TIL densities in intraepithelial (iTILs) and stromal areas were quantified using a 
machine learning-based analytic method.