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E-ISSN 0976-2833 | ISSN 0975-3583
 

Research Article 


Brain Damages in Infants of the First Year of Life Born to Women with Gestational Diabetes Mellitus

Aleksandr Alekseevich Afonin, Anna Yakovlevna Babiyants, Irina Vital'evna Panova, Sof'ya Borisovna Berezhanskaya, Evgeniya Yur'evna Bryksina, Svetlana Khristoforovna Dombayan.

Abstract
The objective of the study was to optimize the diagnostics and prognosis of the course of brain damages in infants born to women with gestational diabetes mellitus.
We have examined 50 newborns born to mothers with gestational diabetes mellitus (the main group) and 17 healthy newborns born to women with physiological course of pregnancy and delivery (the control group). Prospective monitoring of infants has been carried out during the first year of life. All children in the main group had perinatal affection of the central nervous system, persisting in 42.0 per cent of cases by the end of the year. Diabetic fetopathy was diagnosed in 54.0 per cent of newborns. Neurosonography and Doppler sonography of brain vessels were performed over time during the first year of life. The level of neuron-specific enolase, insulin, insulin-like growth factor-1, endothelin-1 was determined by enzyme multiple immunoassay, the content of nitric oxide metabolites - by colorimetric method. Determination of biochemical indicators was carried out at birth, at the age of 1 and 3 months.
High values of neuron-specific enolase, insulin, insulin-like growth factor-1, endothelin-1, decrease of nitric oxide metabolites, brain blood flow idisorder in all children of the main group in comparison with the control data have been established.
Conclusions: In infants born to women with gestational diabetes mellitus, the development of perinatal central nervous system affections and diabetic fetopathy is due to impaired regulation of carbohydrate metabolism and endothelial dysfunction. Pathogenetic mechanisms of brain damages formation have been specified, prognostic criteria of neurological symptomatology preservation by the end of the first year of life have been developed.

Key words: brain damages; infants; gestational diabetes mellitus; endothelial dysfunction


 
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Pubmed Style

Aleksandr Alekseevich Afonin, Anna Yakovlevna Babiyants, Irina Vitalevna Panova, Sofya Borisovna Berezhanskaya, Evgeniya Yurevna Bryksina, Svetlana Khristoforovna Dombayan. Brain Damages in Infants of the First Year of Life Born to Women with Gestational Diabetes Mellitus. . 2020; 11(5): 4-7. doi:10.31838/jcdr.2020.11.05.02


Web Style

Aleksandr Alekseevich Afonin, Anna Yakovlevna Babiyants, Irina Vitalevna Panova, Sofya Borisovna Berezhanskaya, Evgeniya Yurevna Bryksina, Svetlana Khristoforovna Dombayan. Brain Damages in Infants of the First Year of Life Born to Women with Gestational Diabetes Mellitus. http://www.jcdronline.org//?mno=64739 [Access: March 17, 2021]. doi:10.31838/jcdr.2020.11.05.02


AMA (American Medical Association) Style

Aleksandr Alekseevich Afonin, Anna Yakovlevna Babiyants, Irina Vitalevna Panova, Sofya Borisovna Berezhanskaya, Evgeniya Yurevna Bryksina, Svetlana Khristoforovna Dombayan. Brain Damages in Infants of the First Year of Life Born to Women with Gestational Diabetes Mellitus. . 2020; 11(5): 4-7. doi:10.31838/jcdr.2020.11.05.02



Vancouver/ICMJE Style

Aleksandr Alekseevich Afonin, Anna Yakovlevna Babiyants, Irina Vitalevna Panova, Sofya Borisovna Berezhanskaya, Evgeniya Yurevna Bryksina, Svetlana Khristoforovna Dombayan. Brain Damages in Infants of the First Year of Life Born to Women with Gestational Diabetes Mellitus. . (2020), [cited March 17, 2021]; 11(5): 4-7. doi:10.31838/jcdr.2020.11.05.02



Harvard Style

Aleksandr Alekseevich Afonin, Anna Yakovlevna Babiyants, Irina Vitalevna Panova, Sofya Borisovna Berezhanskaya, Evgeniya Yurevna Bryksina, Svetlana Khristoforovna Dombayan (2020) Brain Damages in Infants of the First Year of Life Born to Women with Gestational Diabetes Mellitus. , 11 (5), 4-7. doi:10.31838/jcdr.2020.11.05.02



Turabian Style

Aleksandr Alekseevich Afonin, Anna Yakovlevna Babiyants, Irina Vitalevna Panova, Sofya Borisovna Berezhanskaya, Evgeniya Yurevna Bryksina, Svetlana Khristoforovna Dombayan. 2020. Brain Damages in Infants of the First Year of Life Born to Women with Gestational Diabetes Mellitus. Journal of Cardiovascular Disease Research, 11 (5), 4-7. doi:10.31838/jcdr.2020.11.05.02



Chicago Style

Aleksandr Alekseevich Afonin, Anna Yakovlevna Babiyants, Irina Vitalevna Panova, Sofya Borisovna Berezhanskaya, Evgeniya Yurevna Bryksina, Svetlana Khristoforovna Dombayan. "Brain Damages in Infants of the First Year of Life Born to Women with Gestational Diabetes Mellitus." Journal of Cardiovascular Disease Research 11 (2020), 4-7. doi:10.31838/jcdr.2020.11.05.02



MLA (The Modern Language Association) Style

Aleksandr Alekseevich Afonin, Anna Yakovlevna Babiyants, Irina Vitalevna Panova, Sofya Borisovna Berezhanskaya, Evgeniya Yurevna Bryksina, Svetlana Khristoforovna Dombayan. "Brain Damages in Infants of the First Year of Life Born to Women with Gestational Diabetes Mellitus." Journal of Cardiovascular Disease Research 11.5 (2020), 4-7. Print. doi:10.31838/jcdr.2020.11.05.02



APA (American Psychological Association) Style

Aleksandr Alekseevich Afonin, Anna Yakovlevna Babiyants, Irina Vitalevna Panova, Sofya Borisovna Berezhanskaya, Evgeniya Yurevna Bryksina, Svetlana Khristoforovna Dombayan (2020) Brain Damages in Infants of the First Year of Life Born to Women with Gestational Diabetes Mellitus. Journal of Cardiovascular Disease Research, 11 (5), 4-7. doi:10.31838/jcdr.2020.11.05.02





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