E-ISSN 0976-2833 | ISSN 0975-3583
 

Research Article 


Clinical Effect of the Combination Therapy of Hydroxychloroquine, Azithromycin and Ivermectin in Patients with COVID-19

SatyanandSathi, Anil Kumar Garg, Amit Mittal, Savita Verma, Virendra Singh Saini, Manoj Kumar Singh, Devinder Vohra, Sushil Kumar.

Abstract
Background: The ongoing pandemic has highlighted the need for an effective treatment of COVID-19 patients
and prevention of SARS-CoV-2 community transmission.Methods: We conducted a prospective observational
study on a cohort of 85 COVID-19 patients (80% males, median age 46 years, range 1880 years). Patients were
treated with a triple drug therapy: ivermectin 12 mg once a week, hydroxychloroquine 400 mg twice a day on
the first day and 200 mg twice a day for the next 4 days, and azithromycin 500 mg once a day for 5 days.
Endpoints were assessed by clinical outcomes, death, negative SARS-CoV-2 RNA-PCR test on the tenth day,
and length of the hospital stay.Results: All patients improved except one 70-year-old female, who died on the
third day of admission. The clinical outcome was considered good as 95.24% (80/84) of patients presented a
negative SARS-CoV-2 RNA-PCR test on the tenth day of admission and 90.48% (76/84) were discharged in
stable condition.Conclusions: The response must focus on immediate isolation of COVID-19 patients and their
early treatment to prevent irreversible severe respiratory injury. Our study shows the beneficial effect of triple
drug therapy in terms of clinical recovery, shorter duration of viral carriage, community spread prevention, and
minimal cost of therapy.

Key words: Hydroxychloroquine, Azithromycin, Ivermectin, COVID-19 patients


 
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How to Cite this Article
Pubmed Style

SatyanandSathi, Anil Kumar Garg, Amit Mittal, Savita Verma, Virendra Singh Saini, Manoj Kumar Singh, Devinder Vohra, Sushil Kumar. Clinical Effect of the Combination Therapy of Hydroxychloroquine, Azithromycin and Ivermectin in Patients with COVID-19. J Cardiovasc. Dis. Res.. 2021; 12(5): 61-68. doi:10.31838/jcdr.2021.12.05.11


Web Style

SatyanandSathi, Anil Kumar Garg, Amit Mittal, Savita Verma, Virendra Singh Saini, Manoj Kumar Singh, Devinder Vohra, Sushil Kumar. Clinical Effect of the Combination Therapy of Hydroxychloroquine, Azithromycin and Ivermectin in Patients with COVID-19. http://www.jcdronline.org/?mno=105237 [Access: August 02, 2021]. doi:10.31838/jcdr.2021.12.05.11


AMA (American Medical Association) Style

SatyanandSathi, Anil Kumar Garg, Amit Mittal, Savita Verma, Virendra Singh Saini, Manoj Kumar Singh, Devinder Vohra, Sushil Kumar. Clinical Effect of the Combination Therapy of Hydroxychloroquine, Azithromycin and Ivermectin in Patients with COVID-19. J Cardiovasc. Dis. Res.. 2021; 12(5): 61-68. doi:10.31838/jcdr.2021.12.05.11



Vancouver/ICMJE Style

SatyanandSathi, Anil Kumar Garg, Amit Mittal, Savita Verma, Virendra Singh Saini, Manoj Kumar Singh, Devinder Vohra, Sushil Kumar. Clinical Effect of the Combination Therapy of Hydroxychloroquine, Azithromycin and Ivermectin in Patients with COVID-19. J Cardiovasc. Dis. Res.. (2021), [cited August 02, 2021]; 12(5): 61-68. doi:10.31838/jcdr.2021.12.05.11



Harvard Style

SatyanandSathi, Anil Kumar Garg, Amit Mittal, Savita Verma, Virendra Singh Saini, Manoj Kumar Singh, Devinder Vohra, Sushil Kumar (2021) Clinical Effect of the Combination Therapy of Hydroxychloroquine, Azithromycin and Ivermectin in Patients with COVID-19. J Cardiovasc. Dis. Res., 12 (5), 61-68. doi:10.31838/jcdr.2021.12.05.11



Turabian Style

SatyanandSathi, Anil Kumar Garg, Amit Mittal, Savita Verma, Virendra Singh Saini, Manoj Kumar Singh, Devinder Vohra, Sushil Kumar. 2021. Clinical Effect of the Combination Therapy of Hydroxychloroquine, Azithromycin and Ivermectin in Patients with COVID-19. Journal of Cardiovascular Disease Research, 12 (5), 61-68. doi:10.31838/jcdr.2021.12.05.11



Chicago Style

SatyanandSathi, Anil Kumar Garg, Amit Mittal, Savita Verma, Virendra Singh Saini, Manoj Kumar Singh, Devinder Vohra, Sushil Kumar. "Clinical Effect of the Combination Therapy of Hydroxychloroquine, Azithromycin and Ivermectin in Patients with COVID-19." Journal of Cardiovascular Disease Research 12 (2021), 61-68. doi:10.31838/jcdr.2021.12.05.11



MLA (The Modern Language Association) Style

SatyanandSathi, Anil Kumar Garg, Amit Mittal, Savita Verma, Virendra Singh Saini, Manoj Kumar Singh, Devinder Vohra, Sushil Kumar. "Clinical Effect of the Combination Therapy of Hydroxychloroquine, Azithromycin and Ivermectin in Patients with COVID-19." Journal of Cardiovascular Disease Research 12.5 (2021), 61-68. Print. doi:10.31838/jcdr.2021.12.05.11



APA (American Psychological Association) Style

SatyanandSathi, Anil Kumar Garg, Amit Mittal, Savita Verma, Virendra Singh Saini, Manoj Kumar Singh, Devinder Vohra, Sushil Kumar (2021) Clinical Effect of the Combination Therapy of Hydroxychloroquine, Azithromycin and Ivermectin in Patients with COVID-19. Journal of Cardiovascular Disease Research, 12 (5), 61-68. doi:10.31838/jcdr.2021.12.05.11





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