E-ISSN 0976-2833 | ISSN 0975-3583
 

Research Article 


p16, p63 AND ki67 Expression in Squamous Metaplasia, Cervical Glandular Hyperplasia, Cervical Intraepithelial Neoplasia and Cervical Cancer

Navneet Kaur, HaspreetKaur Gill, Mohanvir Kaur, Abhinandan Arora, Amrinder Kaur.

Abstract
Introduction: Persistent infection with human papilloma virus(HPV) has been the main cause of squamous
metaplasia which in turn may lead to in situ changes and then cervical cancer. p16, p63 and ki67
immunohistochemistry (IHC) can be used as an ancillary method for the diagnosis of these lesions. Aim: To
evaluate the expression of p16, p63 and ki67 in squamous metaplasia, cervical glandular hyperplasia, Cervical
intraepithelial neoplasia (CIN), cervical cancer and correlate histological features with IHC patterns. Settings
and Design: 100 histologically proven cases of above mentioned lesions were taken in a observational study
conducted from august 2018 to 2020. Methods and Material: 100 formalin fixed paraffin embedded blocks from
cervical tissue were subjected to IHC using p16, p63 and ki67. Statistical analysis used: Using the SPSS 10.0
statistical software program. P< 0.05 was considered statistically significant. Results: Positive rates of p16, p63
and ki67 expression in CIN III and cervical cancer were higher than those in CIN I and II but there was no
significant difference between various grades of cervical squamous cell carcinoma. Conclusions: The p16, p63
and ki67 expression positivity increased with the increasing severity of cervical lesions. Thus, high expression
of ki67, p63 indicates neoplastic progression and p16 identifies HPV 16 infection in the uterine cervix.

Key words: p16, p63, ki67, HPV, IHC, CIN


 
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How to Cite this Article
Pubmed Style

Navneet Kaur, HaspreetKaur Gill, Mohanvir Kaur, Abhinandan Arora, Amrinder Kaur. p16, p63 AND ki67 Expression in Squamous Metaplasia, Cervical Glandular Hyperplasia, Cervical Intraepithelial Neoplasia and Cervical Cancer. J Cardiovasc. Dis. Res.. 2021; 12(5): 110-115. doi:10.31838/jcdr.2021.12.05.19


Web Style

Navneet Kaur, HaspreetKaur Gill, Mohanvir Kaur, Abhinandan Arora, Amrinder Kaur. p16, p63 AND ki67 Expression in Squamous Metaplasia, Cervical Glandular Hyperplasia, Cervical Intraepithelial Neoplasia and Cervical Cancer. http://www.jcdronline.org/?mno=106775 [Access: August 05, 2021]. doi:10.31838/jcdr.2021.12.05.19


AMA (American Medical Association) Style

Navneet Kaur, HaspreetKaur Gill, Mohanvir Kaur, Abhinandan Arora, Amrinder Kaur. p16, p63 AND ki67 Expression in Squamous Metaplasia, Cervical Glandular Hyperplasia, Cervical Intraepithelial Neoplasia and Cervical Cancer. J Cardiovasc. Dis. Res.. 2021; 12(5): 110-115. doi:10.31838/jcdr.2021.12.05.19



Vancouver/ICMJE Style

Navneet Kaur, HaspreetKaur Gill, Mohanvir Kaur, Abhinandan Arora, Amrinder Kaur. p16, p63 AND ki67 Expression in Squamous Metaplasia, Cervical Glandular Hyperplasia, Cervical Intraepithelial Neoplasia and Cervical Cancer. J Cardiovasc. Dis. Res.. (2021), [cited August 05, 2021]; 12(5): 110-115. doi:10.31838/jcdr.2021.12.05.19



Harvard Style

Navneet Kaur, HaspreetKaur Gill, Mohanvir Kaur, Abhinandan Arora, Amrinder Kaur (2021) p16, p63 AND ki67 Expression in Squamous Metaplasia, Cervical Glandular Hyperplasia, Cervical Intraepithelial Neoplasia and Cervical Cancer. J Cardiovasc. Dis. Res., 12 (5), 110-115. doi:10.31838/jcdr.2021.12.05.19



Turabian Style

Navneet Kaur, HaspreetKaur Gill, Mohanvir Kaur, Abhinandan Arora, Amrinder Kaur. 2021. p16, p63 AND ki67 Expression in Squamous Metaplasia, Cervical Glandular Hyperplasia, Cervical Intraepithelial Neoplasia and Cervical Cancer. Journal of Cardiovascular Disease Research, 12 (5), 110-115. doi:10.31838/jcdr.2021.12.05.19



Chicago Style

Navneet Kaur, HaspreetKaur Gill, Mohanvir Kaur, Abhinandan Arora, Amrinder Kaur. "p16, p63 AND ki67 Expression in Squamous Metaplasia, Cervical Glandular Hyperplasia, Cervical Intraepithelial Neoplasia and Cervical Cancer." Journal of Cardiovascular Disease Research 12 (2021), 110-115. doi:10.31838/jcdr.2021.12.05.19



MLA (The Modern Language Association) Style

Navneet Kaur, HaspreetKaur Gill, Mohanvir Kaur, Abhinandan Arora, Amrinder Kaur. "p16, p63 AND ki67 Expression in Squamous Metaplasia, Cervical Glandular Hyperplasia, Cervical Intraepithelial Neoplasia and Cervical Cancer." Journal of Cardiovascular Disease Research 12.5 (2021), 110-115. Print. doi:10.31838/jcdr.2021.12.05.19



APA (American Psychological Association) Style

Navneet Kaur, HaspreetKaur Gill, Mohanvir Kaur, Abhinandan Arora, Amrinder Kaur (2021) p16, p63 AND ki67 Expression in Squamous Metaplasia, Cervical Glandular Hyperplasia, Cervical Intraepithelial Neoplasia and Cervical Cancer. Journal of Cardiovascular Disease Research, 12 (5), 110-115. doi:10.31838/jcdr.2021.12.05.19





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