E-ISSN 0976-2833 | ISSN 0975-3583
 

Research Article 


Cardioprotective effect of alcohol extract and seed powder dietary supplementation of quinoa (Chenopodium quinoa) in female rats treated with Doxorubicin

Raghad KH Ibraheem ALjubory and Saleh M Rahim.

Abstract
Doxorubicin (DOX) is an anthracycline drug used for different type of cancer treatment related to
many toxic systemic effects. We examined the cardioprotective potential of Chenopodium quinoa
against DOX cardiotoxicity. 30 female Sprague Dawley rats were randomly assorted into 6 groups.
Control group I: received normal saline with standard rat feed and water ad libitum; DOX group II:
received 15 mg/kg b.w. dosage of single intraperitoneal DOX on the eighth day of the 21-day
experiment period. Co-treatment groups III, IV and V: received 300 mg/kg b.w. of quinoa seeds
ethanol extract, different percentages of (20 and 40%) of dietary supplementation with quinoa seeds
powder (QSP) were given orally throughout the trial period in concomitant with single intraperitoneal
DOX as in DOX group II respectively. Standard group VI: received vitamin C 250 mg/kg b.w daily as
in co-treatment groups. Phytochemical screening and antioxidant activity of quinoa seeds, Biochemical
changes and oxidative stress markers in serum and heart tissue extract were examined. DOX caused
significant increase in serum LDH and CK activity and lower antioxidant enzymes in serum and heart
tissue. Quinoa seed ethanol extract and dietary supplementation with quinoa seed powder ameliorates
DOX-prompted changes in serum and tissue heart by enhancing antioxidant enzyme activities. Quinoa
seeds possesses a majority of phytochemical classes of compounds . Our results suggest that cotreatment
of QSP dietary supplementation markedly improve DOX-induced heart deleterious effects.
The potency of co-treatment of QSP dietary supplementation at 40% is similar to vitamin C. These
results revealed that dietary supplementation with quinoa seed powder might serve as a potential
adjuvant that avoids DOX-induced cardiotoxicity.

Key words: Doxorubicin; Antioxidant; Chenopodium quinoa; Cardiotoxicity; Enzyme markers , oxidative stress


 
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Pubmed Style

Raghad KH Ibraheem ALjubory and Saleh M Rahim. Cardioprotective effect of alcohol extract and seed powder dietary supplementation of quinoa (Chenopodium quinoa) in female rats treated with Doxorubicin. J Cardiovasc. Dis. Res.. 2021; 12(5): 157-163. doi:10.31838/jcdr.2021.12.05.26


Web Style

Raghad KH Ibraheem ALjubory and Saleh M Rahim. Cardioprotective effect of alcohol extract and seed powder dietary supplementation of quinoa (Chenopodium quinoa) in female rats treated with Doxorubicin. http://www.jcdronline.org/?mno=107427 [Access: August 07, 2021]. doi:10.31838/jcdr.2021.12.05.26


AMA (American Medical Association) Style

Raghad KH Ibraheem ALjubory and Saleh M Rahim. Cardioprotective effect of alcohol extract and seed powder dietary supplementation of quinoa (Chenopodium quinoa) in female rats treated with Doxorubicin. J Cardiovasc. Dis. Res.. 2021; 12(5): 157-163. doi:10.31838/jcdr.2021.12.05.26



Vancouver/ICMJE Style

Raghad KH Ibraheem ALjubory and Saleh M Rahim. Cardioprotective effect of alcohol extract and seed powder dietary supplementation of quinoa (Chenopodium quinoa) in female rats treated with Doxorubicin. J Cardiovasc. Dis. Res.. (2021), [cited August 07, 2021]; 12(5): 157-163. doi:10.31838/jcdr.2021.12.05.26



Harvard Style

Raghad KH Ibraheem ALjubory and Saleh M Rahim (2021) Cardioprotective effect of alcohol extract and seed powder dietary supplementation of quinoa (Chenopodium quinoa) in female rats treated with Doxorubicin. J Cardiovasc. Dis. Res., 12 (5), 157-163. doi:10.31838/jcdr.2021.12.05.26



Turabian Style

Raghad KH Ibraheem ALjubory and Saleh M Rahim. 2021. Cardioprotective effect of alcohol extract and seed powder dietary supplementation of quinoa (Chenopodium quinoa) in female rats treated with Doxorubicin. Journal of Cardiovascular Disease Research, 12 (5), 157-163. doi:10.31838/jcdr.2021.12.05.26



Chicago Style

Raghad KH Ibraheem ALjubory and Saleh M Rahim. "Cardioprotective effect of alcohol extract and seed powder dietary supplementation of quinoa (Chenopodium quinoa) in female rats treated with Doxorubicin." Journal of Cardiovascular Disease Research 12 (2021), 157-163. doi:10.31838/jcdr.2021.12.05.26



MLA (The Modern Language Association) Style

Raghad KH Ibraheem ALjubory and Saleh M Rahim. "Cardioprotective effect of alcohol extract and seed powder dietary supplementation of quinoa (Chenopodium quinoa) in female rats treated with Doxorubicin." Journal of Cardiovascular Disease Research 12.5 (2021), 157-163. Print. doi:10.31838/jcdr.2021.12.05.26



APA (American Psychological Association) Style

Raghad KH Ibraheem ALjubory and Saleh M Rahim (2021) Cardioprotective effect of alcohol extract and seed powder dietary supplementation of quinoa (Chenopodium quinoa) in female rats treated with Doxorubicin. Journal of Cardiovascular Disease Research, 12 (5), 157-163. doi:10.31838/jcdr.2021.12.05.26





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