E-ISSN 0976-2833 | ISSN 0975-3583
 

Research Article 


Comparative Effects of Paroxatine and Clomipramine on Locomotor Behaviour in Mice

Mfem CC, Oyama SE, Seriki SA, Nyoro IK.

Abstract
BACKGROUND/AIM: The present study investigates behavioral parallels between stress-induced mice and stressinduced
mice that are treated with antidepressants (paroxatine and clomipramine). This is to determine the effect of
these drugs on the locomotor behaviours of mice exposed to stress. METHOD: Twenty eight (28) Swiss Mice were
divided randomly into four groups of 6 in each group; i.e. group one (control), group two (stressed), group three
(stressed and then treated with paroxatine) and group four (stressed and then treated with clomipramine). Mice in all
the groups were given normal rat chew and water throughout period of experiment. The four groups were then
subjected to tests in both open field and elevated-plus maze apparatus. Open field apparatus and elevated-plus maze
test were the method used to determine locomotor behaviour. These were determined in the frequency of line
crossing, centre-square entry, centre-square duration in the open field apparatus, and open arm entry frequency and
duration. RESULTS: Mice that were stressed without treatment with antidepressant had reduced locomotor activity
when compared with Mice in control group. The stressed groups treated with paroxatine and clomipramine showed
significant increase in locomotor activity(P < 0.05) compared to the stressed non-treated group. The stress group
treated with paroxatine had significant improved locomotor activitywhen compared to the stressed group treated
with clomipramine (P < 0.05). CONCLUSION: Paroxatine and clomipramine administration result in significant
improved locomotor activity in stressed mice. Paroxatine however caused a more significant improvement
inlocomotor activity than clomipramine in mice recovering from stress when the two agents were compared.

Key words: Locomotor activities, Stress, Paroxatine and Clomipramine


 
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How to Cite this Article
Pubmed Style

Mfem CC, Oyama SE, Seriki SA, Nyoro IK. Comparative Effects of Paroxatine and Clomipramine on Locomotor Behaviour in Mice. J Cardiovasc. Dis. Res.. 2021; 12(5): 238-245. doi:0.31838/jcdr.2021.12.05.36


Web Style

Mfem CC, Oyama SE, Seriki SA, Nyoro IK. Comparative Effects of Paroxatine and Clomipramine on Locomotor Behaviour in Mice. http://www.jcdronline.org/?mno=108702 [Access: August 10, 2021]. doi:0.31838/jcdr.2021.12.05.36


AMA (American Medical Association) Style

Mfem CC, Oyama SE, Seriki SA, Nyoro IK. Comparative Effects of Paroxatine and Clomipramine on Locomotor Behaviour in Mice. J Cardiovasc. Dis. Res.. 2021; 12(5): 238-245. doi:0.31838/jcdr.2021.12.05.36



Vancouver/ICMJE Style

Mfem CC, Oyama SE, Seriki SA, Nyoro IK. Comparative Effects of Paroxatine and Clomipramine on Locomotor Behaviour in Mice. J Cardiovasc. Dis. Res.. (2021), [cited August 10, 2021]; 12(5): 238-245. doi:0.31838/jcdr.2021.12.05.36



Harvard Style

Mfem CC, Oyama SE, Seriki SA, Nyoro IK (2021) Comparative Effects of Paroxatine and Clomipramine on Locomotor Behaviour in Mice. J Cardiovasc. Dis. Res., 12 (5), 238-245. doi:0.31838/jcdr.2021.12.05.36



Turabian Style

Mfem CC, Oyama SE, Seriki SA, Nyoro IK. 2021. Comparative Effects of Paroxatine and Clomipramine on Locomotor Behaviour in Mice. Journal of Cardiovascular Disease Research, 12 (5), 238-245. doi:0.31838/jcdr.2021.12.05.36



Chicago Style

Mfem CC, Oyama SE, Seriki SA, Nyoro IK. "Comparative Effects of Paroxatine and Clomipramine on Locomotor Behaviour in Mice." Journal of Cardiovascular Disease Research 12 (2021), 238-245. doi:0.31838/jcdr.2021.12.05.36



MLA (The Modern Language Association) Style

Mfem CC, Oyama SE, Seriki SA, Nyoro IK. "Comparative Effects of Paroxatine and Clomipramine on Locomotor Behaviour in Mice." Journal of Cardiovascular Disease Research 12.5 (2021), 238-245. Print. doi:0.31838/jcdr.2021.12.05.36



APA (American Psychological Association) Style

Mfem CC, Oyama SE, Seriki SA, Nyoro IK (2021) Comparative Effects of Paroxatine and Clomipramine on Locomotor Behaviour in Mice. Journal of Cardiovascular Disease Research, 12 (5), 238-245. doi:0.31838/jcdr.2021.12.05.36





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