E-ISSN 0976-2833 | ISSN 0975-3583
 

Research Article 


Effect of Vaginal Isosorbide Mononitrate versus Effect of Vaginal Dinoprostone on Cervical Ripening for Induction of Labor

Walid Abd-ELsalam, Youssef Abo-Elwan, Fatma Al-Zahraa Sherif, Basem Hamed.

Abstract
Background: Labor induction has risen significantly over the last twenty years. Induction of labor is
indicated for either maternal (preeclampsia, pregnancy-induced hypertension) or fetal (pregnancy
induced hypertension, preeclampsia, and postdate pregnancy).
Aim of Work: The aim of the study to assess the best method in induction of labor either vaginal
Isosorbide Mononitrate or vaginal Dinoprostone.
Patients and Methods: A randomized clinical trial was carried out on 44 full-term pregnant women
who were admitted for induction of labor in Zagazig University Hospitals in the period of November
2020 to August 2021. Patients were divided into two groups: Group A included 22 full term pregnant
females who received 20mg of intravaginal Isosorbide Mononitrate (Effox20mg, Minapharm). Group
B included 22 full-term pregnant females who received 3mg of vaginal Dinoprostone (Dinoglandin E2,
Rotabiogen) single dose.
Results: There was little difference between the effectiveness of 20mg of intravaginal Isosorbide
Mononitrate and 3mg of vaginal Dinoprostone in induction of labor. The safety profiles of both drugs
were similar, but isosorbide mononitrate administration is considered a low-risk method of labour
induction for pregnant women at full term. Conclusions: This study demonstrated that it is safe to use
IMN in induction of labor with less side effects than Dinoprostone as cause of failed induction with
Dinoprostone was only due to uterine hyperstimulation that lead to sudden and sever fetal distress,
while with IMN there were different causes including fetal distress or 2nd ,3rd degree meconium on
AROM. Also, with Dinoprostone there was higher incidence of neonatal admission to NICU after birth
than IMN that has no incidence of neonatal admission to NICU

Key words: Cervical ripening, Induction of Labor, Isosorbide, Mononitrate, Misoprostol


 
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How to Cite this Article
Pubmed Style

Walid Abd-ELsalam, Youssef Abo-Elwan, Fatma Al-Zahraa Sherif, Basem Hamed. Effect of Vaginal Isosorbide Mononitrate versus Effect of Vaginal Dinoprostone on Cervical Ripening for Induction of Labor. J Cardiovasc. Dis. Res.. 2021; 12(5): 911-919. doi:10.31838/jcdr.2021.12.05.121


Web Style

Walid Abd-ELsalam, Youssef Abo-Elwan, Fatma Al-Zahraa Sherif, Basem Hamed. Effect of Vaginal Isosorbide Mononitrate versus Effect of Vaginal Dinoprostone on Cervical Ripening for Induction of Labor. http://www.jcdronline.org/?mno=122067 [Access: September 09, 2021]. doi:10.31838/jcdr.2021.12.05.121


AMA (American Medical Association) Style

Walid Abd-ELsalam, Youssef Abo-Elwan, Fatma Al-Zahraa Sherif, Basem Hamed. Effect of Vaginal Isosorbide Mononitrate versus Effect of Vaginal Dinoprostone on Cervical Ripening for Induction of Labor. J Cardiovasc. Dis. Res.. 2021; 12(5): 911-919. doi:10.31838/jcdr.2021.12.05.121



Vancouver/ICMJE Style

Walid Abd-ELsalam, Youssef Abo-Elwan, Fatma Al-Zahraa Sherif, Basem Hamed. Effect of Vaginal Isosorbide Mononitrate versus Effect of Vaginal Dinoprostone on Cervical Ripening for Induction of Labor. J Cardiovasc. Dis. Res.. (2021), [cited September 09, 2021]; 12(5): 911-919. doi:10.31838/jcdr.2021.12.05.121



Harvard Style

Walid Abd-ELsalam, Youssef Abo-Elwan, Fatma Al-Zahraa Sherif, Basem Hamed (2021) Effect of Vaginal Isosorbide Mononitrate versus Effect of Vaginal Dinoprostone on Cervical Ripening for Induction of Labor. J Cardiovasc. Dis. Res., 12 (5), 911-919. doi:10.31838/jcdr.2021.12.05.121



Turabian Style

Walid Abd-ELsalam, Youssef Abo-Elwan, Fatma Al-Zahraa Sherif, Basem Hamed. 2021. Effect of Vaginal Isosorbide Mononitrate versus Effect of Vaginal Dinoprostone on Cervical Ripening for Induction of Labor. Journal of Cardiovascular Disease Research, 12 (5), 911-919. doi:10.31838/jcdr.2021.12.05.121



Chicago Style

Walid Abd-ELsalam, Youssef Abo-Elwan, Fatma Al-Zahraa Sherif, Basem Hamed. "Effect of Vaginal Isosorbide Mononitrate versus Effect of Vaginal Dinoprostone on Cervical Ripening for Induction of Labor." Journal of Cardiovascular Disease Research 12 (2021), 911-919. doi:10.31838/jcdr.2021.12.05.121



MLA (The Modern Language Association) Style

Walid Abd-ELsalam, Youssef Abo-Elwan, Fatma Al-Zahraa Sherif, Basem Hamed. "Effect of Vaginal Isosorbide Mononitrate versus Effect of Vaginal Dinoprostone on Cervical Ripening for Induction of Labor." Journal of Cardiovascular Disease Research 12.5 (2021), 911-919. Print. doi:10.31838/jcdr.2021.12.05.121



APA (American Psychological Association) Style

Walid Abd-ELsalam, Youssef Abo-Elwan, Fatma Al-Zahraa Sherif, Basem Hamed (2021) Effect of Vaginal Isosorbide Mononitrate versus Effect of Vaginal Dinoprostone on Cervical Ripening for Induction of Labor. Journal of Cardiovascular Disease Research, 12 (5), 911-919. doi:10.31838/jcdr.2021.12.05.121





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