E-ISSN 0976-2833 | ISSN 0975-3583
 

Research Article 


Calcineurin Inhibitors in the Treatment of Alopecia Areata

Mona Abd Elkhalik Shabaan,Waleed Mohamed El Balat, Amany Abdelrahman Nassar.

Abstract
Topical calcineurin inhibitors (TCI) are a relatively new class of drugs used in dermatology. There are
two drug forms available tacrolimus 0.03% or 0.1% ointment and 1.0% pimecrolimus cream. The
drugs act by inhibiting synthesis of proinflammatory cytokines. The only approved indication for using
TCI is treatment of atopic dermatitis. The TCI may be used as an alternative therapy to corticosteroids.
Tacrolimus is used to treat moderate-to-severe atopic dermatitis, pimecrolimus mild-to-moderate
atopic dermatitis. Topical calcineurin inhibitors do not cause skin atrophy and the drug absorption
through the skin is minimal. The TCI have been well-studied, their efficacy was evaluated in a number
of vast, long-term studies. The anti-inflammatory potency of tacrolimus ointment is similar to a
corticosteroid with moderate activity, while the latter is clearly more active than pimecrolimus cream.
Topical calcineurin inhibitors significantly relieve pruritus in atopic eczema.

Key words: topical calcineurin inhibitors, tacrolimus, pimecrolimus


 
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How to Cite this Article
Pubmed Style

Mona Abd Elkhalik Shabaan,Waleed Mohamed El Balat, Amany Abdelrahman Nassar. Calcineurin Inhibitors in the Treatment of Alopecia Areata. J Cardiovasc. Dis. Res.. 2021; 12(5): 933-936. doi:10.31838/jcdr.2021.12.05.123


Web Style

Mona Abd Elkhalik Shabaan,Waleed Mohamed El Balat, Amany Abdelrahman Nassar. Calcineurin Inhibitors in the Treatment of Alopecia Areata. http://www.jcdronline.org/?mno=122081 [Access: September 09, 2021]. doi:10.31838/jcdr.2021.12.05.123


AMA (American Medical Association) Style

Mona Abd Elkhalik Shabaan,Waleed Mohamed El Balat, Amany Abdelrahman Nassar. Calcineurin Inhibitors in the Treatment of Alopecia Areata. J Cardiovasc. Dis. Res.. 2021; 12(5): 933-936. doi:10.31838/jcdr.2021.12.05.123



Vancouver/ICMJE Style

Mona Abd Elkhalik Shabaan,Waleed Mohamed El Balat, Amany Abdelrahman Nassar. Calcineurin Inhibitors in the Treatment of Alopecia Areata. J Cardiovasc. Dis. Res.. (2021), [cited September 09, 2021]; 12(5): 933-936. doi:10.31838/jcdr.2021.12.05.123



Harvard Style

Mona Abd Elkhalik Shabaan,Waleed Mohamed El Balat, Amany Abdelrahman Nassar (2021) Calcineurin Inhibitors in the Treatment of Alopecia Areata. J Cardiovasc. Dis. Res., 12 (5), 933-936. doi:10.31838/jcdr.2021.12.05.123



Turabian Style

Mona Abd Elkhalik Shabaan,Waleed Mohamed El Balat, Amany Abdelrahman Nassar. 2021. Calcineurin Inhibitors in the Treatment of Alopecia Areata. Journal of Cardiovascular Disease Research, 12 (5), 933-936. doi:10.31838/jcdr.2021.12.05.123



Chicago Style

Mona Abd Elkhalik Shabaan,Waleed Mohamed El Balat, Amany Abdelrahman Nassar. "Calcineurin Inhibitors in the Treatment of Alopecia Areata." Journal of Cardiovascular Disease Research 12 (2021), 933-936. doi:10.31838/jcdr.2021.12.05.123



MLA (The Modern Language Association) Style

Mona Abd Elkhalik Shabaan,Waleed Mohamed El Balat, Amany Abdelrahman Nassar. "Calcineurin Inhibitors in the Treatment of Alopecia Areata." Journal of Cardiovascular Disease Research 12.5 (2021), 933-936. Print. doi:10.31838/jcdr.2021.12.05.123



APA (American Psychological Association) Style

Mona Abd Elkhalik Shabaan,Waleed Mohamed El Balat, Amany Abdelrahman Nassar (2021) Calcineurin Inhibitors in the Treatment of Alopecia Areata. Journal of Cardiovascular Disease Research, 12 (5), 933-936. doi:10.31838/jcdr.2021.12.05.123





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