E-ISSN 0976-2833 | ISSN 0975-3583
 

Research Article 


Impact of compaction and re-compaction on granule properties in dry granulation process

Saroj Kumar Rout, Prashant Tiwari, Durga Madhab Kar.

Abstract
Dry granulation is defined as a process whereby powder of different physical properties are combined to form
denser, bigger, permanent masses with the aid of some tangible or intangible external agents. In dry-granulation
roller pressure is the driving force. Careful selection of quantitative composition of functional ingredients has big
role to play in the scalability of the manufacturing process, when drug load as high as 66.67%w/w. Metformin
hydrochloride has inherent issue of flowability and compressibility. At high drug load gives little space for other
functional inactive ingredients; hence it becomes more critical to choose efficient highly compressible diluent of
at equal quantitative ratio with dry binder. Better compressible diluents along with dry binder also add flexibility
and helps re- cycling of granules for better results. Physical property of selected individual ingredients and
mixture of ingredients has direct impaction on compressibility of granules, solid fraction, density and particle
size distribution of compressed granules. Current dry granulation study with composition of Lactose anhydrous
and Silicified Microcrystalline Cellulose along with 2% w/w hydroxy propyl cellulose gives flexibility of
recycling to high drug load Metformin hydrochloride granules, this helps to improve its tabletability

Key words: Dry granulation, High drug load, recycling, tabletability


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Saroj Kumar Rout
Articles by Prashant Tiwari
Articles by Durga Madhab Kar
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Saroj Kumar Rout, Prashant Tiwari, Durga Madhab Kar. Impact of compaction and re-compaction on granule properties in dry granulation process. J Cardiovasc. Dis. Res.. 2021; 12(5): 975-985. doi:10.31838/jcdr.2021.12.05.130


Web Style

Saroj Kumar Rout, Prashant Tiwari, Durga Madhab Kar. Impact of compaction and re-compaction on granule properties in dry granulation process. http://www.jcdronline.org/?mno=123522 [Access: September 12, 2021]. doi:10.31838/jcdr.2021.12.05.130


AMA (American Medical Association) Style

Saroj Kumar Rout, Prashant Tiwari, Durga Madhab Kar. Impact of compaction and re-compaction on granule properties in dry granulation process. J Cardiovasc. Dis. Res.. 2021; 12(5): 975-985. doi:10.31838/jcdr.2021.12.05.130



Vancouver/ICMJE Style

Saroj Kumar Rout, Prashant Tiwari, Durga Madhab Kar. Impact of compaction and re-compaction on granule properties in dry granulation process. J Cardiovasc. Dis. Res.. (2021), [cited September 12, 2021]; 12(5): 975-985. doi:10.31838/jcdr.2021.12.05.130



Harvard Style

Saroj Kumar Rout, Prashant Tiwari, Durga Madhab Kar (2021) Impact of compaction and re-compaction on granule properties in dry granulation process. J Cardiovasc. Dis. Res., 12 (5), 975-985. doi:10.31838/jcdr.2021.12.05.130



Turabian Style

Saroj Kumar Rout, Prashant Tiwari, Durga Madhab Kar. 2021. Impact of compaction and re-compaction on granule properties in dry granulation process. Journal of Cardiovascular Disease Research, 12 (5), 975-985. doi:10.31838/jcdr.2021.12.05.130



Chicago Style

Saroj Kumar Rout, Prashant Tiwari, Durga Madhab Kar. "Impact of compaction and re-compaction on granule properties in dry granulation process." Journal of Cardiovascular Disease Research 12 (2021), 975-985. doi:10.31838/jcdr.2021.12.05.130



MLA (The Modern Language Association) Style

Saroj Kumar Rout, Prashant Tiwari, Durga Madhab Kar. "Impact of compaction and re-compaction on granule properties in dry granulation process." Journal of Cardiovascular Disease Research 12.5 (2021), 975-985. Print. doi:10.31838/jcdr.2021.12.05.130



APA (American Psychological Association) Style

Saroj Kumar Rout, Prashant Tiwari, Durga Madhab Kar (2021) Impact of compaction and re-compaction on granule properties in dry granulation process. Journal of Cardiovascular Disease Research, 12 (5), 975-985. doi:10.31838/jcdr.2021.12.05.130





Most Viewed Articles
  • Effects of right ventricular septal versus apical pacing on plasma natriuretic peptide levels
    nikoo M.H, ghaedian m. m., kafi M., fakhrpour A., Jorat M. V., Pakfetrat M., Ostovan M., Zahra Emkanjoo
    J Cardiovasc. Dis. Res.. 2011; 2(2): 104-109
    » Abstract » doi: 10.4103/0975-3583.83036

  • Massive pericardial effusion as the only manifestation of primary hypothyroidism
    Radheshyam Purkait , Anand Prasad , Ramchandra Bhadra , Arindam Basu
    J Cardiovasc. Dis. Res.. 2013; 4(4): 248-250
    » Abstract » doi: 10.1016/j.jcdr.2014.01.001

  • Impact of light exercises in selective cognitive response andhandballshooting accuracy performance in Mesopotamia handball players
    Ahuda Naji Zaidan, Qusay Mohammed Hamdan, Mohammed Kadhim Saleh, Samer Saadoun Abd El , Rida
    J Cardiovasc. Dis. Res.. 2021; 12(2): 141-145
    » Abstract » doi: 10.31838/jcdr.2021.12.02.18

  • Reduced nitrate level in individuals with hypertension and diabetes
    Shiekh Gazalla Ayub, Taha Ayub, Saquib Naveed Khan, Rubiya Dar, Khurshid Iqbal Andrabi
    J Cardiovasc. Dis. Res.. 2011; 2(3): 172-176
    » Abstract » doi: 10.4103/0975-3583.85264

  • Factor analysis of risk variables associated with metabolic syndrome in adult Asian Indians
    Mithun Das, Susil Pal, Arnab Ghosh
    J Cardiovasc. Dis. Res.. 2010; 1(2): 86-91
    » Abstract » doi: 10.4103/0975-3583.64442

  • Most Downloaded
  • Assessment of the Knowledge and Attitude of Male Students towards Smoking Based on Health Belief Model
    Rafat Rezapour-Nasrabad, Fatemeh Izadi, Atousa Karimi, Fateme Shariati Far, Khatereh Rostami, Amin Kiani, Afsaneh Ghasemi
    J Cardiovasc. Dis. Res.. 2020; 11(4): 116-121
    » Abstract » doi: 10.31838/jcdr.2020.11.04.20

  • Diabetic Retinopathy, The Automated of Detection of Retinal Fundus Images with Probabilistic Neural Networks (PNN)
    Elvina Amanda, Marischa Elveny, Rahmad Syah
    J Cardiovasc. Dis. Res.. 2020; 11(4): 302-306
    » Abstract » doi: 10.31838/jcdr.2020.11.04.54

  • Investigation of the Relationship between Social Support and Adherence to Treatment among Elderly Individuals with Type II Diabetes Mellitus
    Afsaneh Ghasemi, Rafat Rezapour-Nasrabad, Leila Nikrouz, Fatemeh Izadi, Atousa Karimi, Fateme Shariati Far, Zahra Khiali
    J Cardiovasc. Dis. Res.. 2020; 11(4): 122-129
    » Abstract » doi: 10.31838/jcdr.2020.11.04.21

  • Cardio-Vascular Disease Classification Using Stacked Segmentation Model and Convolutional Neural Networks
    G. Charlyn Pushpa Latha, S. Sridhar, S. Prithi, T. Anitha
    J Cardiovasc. Dis. Res.. 2020; 11(4): 26-31
    » Abstract » doi: 10.31838/jcdr.2020.11.04.05

  • The Prediction of the Bisoprolol Effectiveness in Patients with Stable Coronary Artery Disease with Post-Infarction Cardiosclerosis
    Svetlana S. Bunova, Ol'ga V. Zamahina, Nikolaj A. Nikolaev, Nina I.Zhernakova, Andrey A.Grishchenko
    J Cardiovasc. Dis. Res.. 2020; 11(4): 105-109
    » Abstract » doi: 10.31838/jcdr.2020.11.04.18

  • Most Cited Articles