E-ISSN 0976-2833 | ISSN 0975-3583
 

Research Article 


Role of Dynamic Contrast Enhanced MRIPerfusion in the Assessment of Vascular Permeability of Head and Neck Squamous Cell Carcinoma as a Predictor of Treatment Response

Mostafa A. Khaled, Eman Geneidi, Togan Taha, Eman Darwish, Reham Mohammed Fahem.

Abstract
Background: Cancers of squamous cell type are of growing incidence, especially those affecting the head and neck.
Emerging non-invasive radiological tools can now aid in predicting and monitoring response of tumor tissue to
treatment, hence improving the whole treatment plan. One of these emerging modalities is dynamic contrast
enhanced magnetic resonance imaging (DCE-MRI), which is further investigated as regards its accuracy in
predicting disease prognosis and monitoring changes in tumor characteristics with treatment. Methods: DCE-MRI
perfusion was performed for 14 patients before and after receiving non-invasive treatment for different types of head
and neck squamous cell carcinoma. Pharmakokinentic parameters were measures and compared before and after
treatment including (Ktrans, Kep, Vp and iAUC). Results: 14 patients with a total of 40 lesions were included in the
study. In all primary and nodal sites, Ktrans values were significantly lower in normal tissue compared to tumoral
sites with a p value as low as 0. Pre-treatment values for Ktrans, Kep and iAuc showed statistically significant lower
values in post-treatment scans compared to pre-treatment scans as regards Ktrans, Kep and iAUC values with p
values of about 0.

Key words: Ktrans, Kep and IAUC can be used as significant markers for assessment of tumor response in patients with HNSCC, Further studies are required to correlate the values between responders and nonresponders.


 
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How to Cite this Article
Pubmed Style

Mostafa A. Khaled, Eman Geneidi, Togan Taha, Eman Darwish, Reham Mohammed Fahem. Role of Dynamic Contrast Enhanced MRIPerfusion in the Assessment of Vascular Permeability of Head and Neck Squamous Cell Carcinoma as a Predictor of Treatment Response. J Cardiovasc. Dis. Res.. 2021; 12(6): 44-48. doi:10.31838/jcdr.2021.12.06.06


Web Style

Mostafa A. Khaled, Eman Geneidi, Togan Taha, Eman Darwish, Reham Mohammed Fahem. Role of Dynamic Contrast Enhanced MRIPerfusion in the Assessment of Vascular Permeability of Head and Neck Squamous Cell Carcinoma as a Predictor of Treatment Response. http://www.jcdronline.org/?mno=125966 [Access: September 20, 2021]. doi:10.31838/jcdr.2021.12.06.06


AMA (American Medical Association) Style

Mostafa A. Khaled, Eman Geneidi, Togan Taha, Eman Darwish, Reham Mohammed Fahem. Role of Dynamic Contrast Enhanced MRIPerfusion in the Assessment of Vascular Permeability of Head and Neck Squamous Cell Carcinoma as a Predictor of Treatment Response. J Cardiovasc. Dis. Res.. 2021; 12(6): 44-48. doi:10.31838/jcdr.2021.12.06.06



Vancouver/ICMJE Style

Mostafa A. Khaled, Eman Geneidi, Togan Taha, Eman Darwish, Reham Mohammed Fahem. Role of Dynamic Contrast Enhanced MRIPerfusion in the Assessment of Vascular Permeability of Head and Neck Squamous Cell Carcinoma as a Predictor of Treatment Response. J Cardiovasc. Dis. Res.. (2021), [cited September 20, 2021]; 12(6): 44-48. doi:10.31838/jcdr.2021.12.06.06



Harvard Style

Mostafa A. Khaled, Eman Geneidi, Togan Taha, Eman Darwish, Reham Mohammed Fahem (2021) Role of Dynamic Contrast Enhanced MRIPerfusion in the Assessment of Vascular Permeability of Head and Neck Squamous Cell Carcinoma as a Predictor of Treatment Response. J Cardiovasc. Dis. Res., 12 (6), 44-48. doi:10.31838/jcdr.2021.12.06.06



Turabian Style

Mostafa A. Khaled, Eman Geneidi, Togan Taha, Eman Darwish, Reham Mohammed Fahem. 2021. Role of Dynamic Contrast Enhanced MRIPerfusion in the Assessment of Vascular Permeability of Head and Neck Squamous Cell Carcinoma as a Predictor of Treatment Response. Journal of Cardiovascular Disease Research, 12 (6), 44-48. doi:10.31838/jcdr.2021.12.06.06



Chicago Style

Mostafa A. Khaled, Eman Geneidi, Togan Taha, Eman Darwish, Reham Mohammed Fahem. "Role of Dynamic Contrast Enhanced MRIPerfusion in the Assessment of Vascular Permeability of Head and Neck Squamous Cell Carcinoma as a Predictor of Treatment Response." Journal of Cardiovascular Disease Research 12 (2021), 44-48. doi:10.31838/jcdr.2021.12.06.06



MLA (The Modern Language Association) Style

Mostafa A. Khaled, Eman Geneidi, Togan Taha, Eman Darwish, Reham Mohammed Fahem. "Role of Dynamic Contrast Enhanced MRIPerfusion in the Assessment of Vascular Permeability of Head and Neck Squamous Cell Carcinoma as a Predictor of Treatment Response." Journal of Cardiovascular Disease Research 12.6 (2021), 44-48. Print. doi:10.31838/jcdr.2021.12.06.06



APA (American Psychological Association) Style

Mostafa A. Khaled, Eman Geneidi, Togan Taha, Eman Darwish, Reham Mohammed Fahem (2021) Role of Dynamic Contrast Enhanced MRIPerfusion in the Assessment of Vascular Permeability of Head and Neck Squamous Cell Carcinoma as a Predictor of Treatment Response. Journal of Cardiovascular Disease Research, 12 (6), 44-48. doi:10.31838/jcdr.2021.12.06.06





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