E-ISSN 0976-2833 | ISSN 0975-3583
 

Research Article 


Assessment Of Ankle Brachial Index and Osteopontin In Type 2 Diabetic Individuals With Lower Extremity Arterial Disease

Jehan Saeed, Sally Mahmoud Saeed, Ali Irhoumah Mohamed, Mohamed Gaber Hamed.

Abstract
Background:Lower extremity arterial disease (LEAD) is a major endemic disease with an
alarming increased prevalence worldwide and it is a major manifestation of systemic
atherosclerosis with severe associated cardiovascular, lower limb and functional
complications.The anklebrachial index (ABI) is a simple, non-invasive, widely used test that
detects lower extremity arterial disease.Osteopontin (OPN) is a multifunctional protein
independently discovered by investigators from diverse scientific backgrounds and
implicated in a broad array of pathological process.
Objective: This study aimed toinvestigate the differencesin ABI measurementsand serum
OPN levels between type 2 diabetic (T2D) subjects with and without LEAD.
Patients and Methods: This case control study was conducted at the Internal Medicine,
Endocrinology Unit and Biochemistry Departments of Zagazig University Hospitals. 30
participants were classified into two groups. Group 1(n =30) healthy subjects (control),
Group 2 (n =30) T2D diabetic subjects, who were further subdivided into two groups: 2A
(n=15) T2D subjects with LEAD and 2B T2D subjects without LEAD. Measurement of
Ankle brachial index madeby handheld doppler.Serum osteopontin levels were performed by
ELISA kits.
Results:Ankle brachial index measurements were significantly lower among diabetic with
LEAD group compared to diabetic without LEAD group (p=0.000) and osteopontin values
was higher in diabetic with LEAD than diabetic without LEAD group with highly significant
results (p=0.000).
Conclusion: The study concluded thatABI measurements and serum OPN levels have
important value in detection of lower extremity arterial disease in subjects with type 2
diabetes mellitus.

Key words: Ankle brachial index, Lower extremity arterial disease, Type 2 D Mellitus


 
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How to Cite this Article
Pubmed Style

Jehan Saeed , Sally Mahmoud Saeed, Ali Irhoumah Mohamed, Mohamed Gaber Hamed. Assessment Of Ankle Brachial Index and Osteopontin In Type 2 Diabetic Individuals With Lower Extremity Arterial Disease. J Cardiovasc. Dis. Res.. 2021; 12(6): 191-196. doi:10.31838/jcdr.2021.12.06.27


Web Style

Jehan Saeed , Sally Mahmoud Saeed, Ali Irhoumah Mohamed, Mohamed Gaber Hamed. Assessment Of Ankle Brachial Index and Osteopontin In Type 2 Diabetic Individuals With Lower Extremity Arterial Disease. http://www.jcdronline.org/?mno=134310 [Access: December 04, 2021]. doi:10.31838/jcdr.2021.12.06.27


AMA (American Medical Association) Style

Jehan Saeed , Sally Mahmoud Saeed, Ali Irhoumah Mohamed, Mohamed Gaber Hamed. Assessment Of Ankle Brachial Index and Osteopontin In Type 2 Diabetic Individuals With Lower Extremity Arterial Disease. J Cardiovasc. Dis. Res.. 2021; 12(6): 191-196. doi:10.31838/jcdr.2021.12.06.27



Vancouver/ICMJE Style

Jehan Saeed , Sally Mahmoud Saeed, Ali Irhoumah Mohamed, Mohamed Gaber Hamed. Assessment Of Ankle Brachial Index and Osteopontin In Type 2 Diabetic Individuals With Lower Extremity Arterial Disease. J Cardiovasc. Dis. Res.. (2021), [cited December 04, 2021]; 12(6): 191-196. doi:10.31838/jcdr.2021.12.06.27



Harvard Style

Jehan Saeed , Sally Mahmoud Saeed, Ali Irhoumah Mohamed, Mohamed Gaber Hamed (2021) Assessment Of Ankle Brachial Index and Osteopontin In Type 2 Diabetic Individuals With Lower Extremity Arterial Disease. J Cardiovasc. Dis. Res., 12 (6), 191-196. doi:10.31838/jcdr.2021.12.06.27



Turabian Style

Jehan Saeed , Sally Mahmoud Saeed, Ali Irhoumah Mohamed, Mohamed Gaber Hamed. 2021. Assessment Of Ankle Brachial Index and Osteopontin In Type 2 Diabetic Individuals With Lower Extremity Arterial Disease. Journal of Cardiovascular Disease Research, 12 (6), 191-196. doi:10.31838/jcdr.2021.12.06.27



Chicago Style

Jehan Saeed , Sally Mahmoud Saeed, Ali Irhoumah Mohamed, Mohamed Gaber Hamed. "Assessment Of Ankle Brachial Index and Osteopontin In Type 2 Diabetic Individuals With Lower Extremity Arterial Disease." Journal of Cardiovascular Disease Research 12 (2021), 191-196. doi:10.31838/jcdr.2021.12.06.27



MLA (The Modern Language Association) Style

Jehan Saeed , Sally Mahmoud Saeed, Ali Irhoumah Mohamed, Mohamed Gaber Hamed. "Assessment Of Ankle Brachial Index and Osteopontin In Type 2 Diabetic Individuals With Lower Extremity Arterial Disease." Journal of Cardiovascular Disease Research 12.6 (2021), 191-196. Print. doi:10.31838/jcdr.2021.12.06.27



APA (American Psychological Association) Style

Jehan Saeed , Sally Mahmoud Saeed, Ali Irhoumah Mohamed, Mohamed Gaber Hamed (2021) Assessment Of Ankle Brachial Index and Osteopontin In Type 2 Diabetic Individuals With Lower Extremity Arterial Disease. Journal of Cardiovascular Disease Research, 12 (6), 191-196. doi:10.31838/jcdr.2021.12.06.27





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