E-ISSN 0976-2833 | ISSN 0975-3583
 

Research Article 


Value of Global Left Ventricular Strain Using 2D Speckle Tracking for Prediction of Adverse Events in Severe Asymptomatic Aortic Valve Stenosis

Ahmed Youssif Abd-Elkhalek, Hesham khaled Rasheed, Sahar Abdelaal Abdullah, Ahmed Yousuf Nammour.

Abstract
Background: Calcific aortic stenosis (AS) is the most common form of valvular heart disease in
developed countries. Patients with severe aortic stenosis and a preserved LV ejection fraction have
impaired global longitudinal strain (GLS).
Objective: This study aimed toassess the prognostic value of global left ventricular strain using 2-
dimensional speckle tracking for patients with severe asymptomatic aortic stenosis and its
correlation with appearance of symptoms and or major adverse cardiovascular events (MACE).
Patients and Methods:A total 160 patients were included in this observational study,80 patients
with isolated senile degenerative severe aortic valve stenosis, all patients were asymptomatic at the
beginning of the study and furthermore, we subdivided the patient group into 2 subgroups: patients
who developed symptoms and those who remained asymptomatic.
80 normal healthy age and sex matched subjects. All subjects were evaluated by history taking,
clinical examination, routine laboratory investigations and a 12-lead ECG. Conventional echo was
performed on all patients to assess left ventricular function and aortic valve parameters. Peak
systolic strain was measured from the mean strain profile for a total of 17 segments of the left
ventricle for the longitudinal strain, then Global longitudinal strain was calculated separately as the
average of the sum of the studied segments. All patients were followed up clinically and the
development of any symptom of the cardinal symptoms of aortic stenosis was recorded.
Results: By comparing the global longitudinal strain in the two groups, the mean GLS in the
patient group was -18.70 2.08 % ranging from -23 to -15 % and in the control group the mean
GLS was -22.50 1.13 % ranging from -24 to -21 %, showing statistical significance between
both groups. The mean GLS in the subgroup of patients who developed symptoms was -17.81
1.10 % ranging from - 19.0 -15.0 % and the mean GLS in the subgroup of patients who remained
asymptomatic was -21.78 1.66 % ranging from -23 to -18 %, there was a statistical significance
between both subgroups.
Conclusion:Asymptomatic severe aortic stenosis is not always as benign as it seems to be and
although severe aortic stenosis may remain silent for a long period, life expectancy is seriously
reduced after development of symptoms. Global Longitudinal strain (GLS) can be used in
assessment of severe AS due to its robust diagnostic and prognostic values over standard
echocardiography.

Key words: Global Left Ventricular Strain, 2D Speckle Tracking, Aortic Valve Stenosis


 
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Pubmed Style

Ahmed Youssif Abd-Elkhalek, Hesham khaled Rasheed, Sahar Abdelaal Abdullah, Ahmed Yousuf Nammour. Value of Global Left Ventricular Strain Using 2D Speckle Tracking for Prediction of Adverse Events in Severe Asymptomatic Aortic Valve Stenosis. J Cardiovasc. Dis. Res.. 2021; 12(6): 308-317. doi:10.31838/jcdr.2021.12.06.40


Web Style

Ahmed Youssif Abd-Elkhalek, Hesham khaled Rasheed, Sahar Abdelaal Abdullah, Ahmed Yousuf Nammour. Value of Global Left Ventricular Strain Using 2D Speckle Tracking for Prediction of Adverse Events in Severe Asymptomatic Aortic Valve Stenosis. http://www.jcdronline.org/?mno=137340 [Access: December 04, 2021]. doi:10.31838/jcdr.2021.12.06.40


AMA (American Medical Association) Style

Ahmed Youssif Abd-Elkhalek, Hesham khaled Rasheed, Sahar Abdelaal Abdullah, Ahmed Yousuf Nammour. Value of Global Left Ventricular Strain Using 2D Speckle Tracking for Prediction of Adverse Events in Severe Asymptomatic Aortic Valve Stenosis. J Cardiovasc. Dis. Res.. 2021; 12(6): 308-317. doi:10.31838/jcdr.2021.12.06.40



Vancouver/ICMJE Style

Ahmed Youssif Abd-Elkhalek, Hesham khaled Rasheed, Sahar Abdelaal Abdullah, Ahmed Yousuf Nammour. Value of Global Left Ventricular Strain Using 2D Speckle Tracking for Prediction of Adverse Events in Severe Asymptomatic Aortic Valve Stenosis. J Cardiovasc. Dis. Res.. (2021), [cited December 04, 2021]; 12(6): 308-317. doi:10.31838/jcdr.2021.12.06.40



Harvard Style

Ahmed Youssif Abd-Elkhalek, Hesham khaled Rasheed, Sahar Abdelaal Abdullah, Ahmed Yousuf Nammour (2021) Value of Global Left Ventricular Strain Using 2D Speckle Tracking for Prediction of Adverse Events in Severe Asymptomatic Aortic Valve Stenosis. J Cardiovasc. Dis. Res., 12 (6), 308-317. doi:10.31838/jcdr.2021.12.06.40



Turabian Style

Ahmed Youssif Abd-Elkhalek, Hesham khaled Rasheed, Sahar Abdelaal Abdullah, Ahmed Yousuf Nammour. 2021. Value of Global Left Ventricular Strain Using 2D Speckle Tracking for Prediction of Adverse Events in Severe Asymptomatic Aortic Valve Stenosis. Journal of Cardiovascular Disease Research, 12 (6), 308-317. doi:10.31838/jcdr.2021.12.06.40



Chicago Style

Ahmed Youssif Abd-Elkhalek, Hesham khaled Rasheed, Sahar Abdelaal Abdullah, Ahmed Yousuf Nammour. "Value of Global Left Ventricular Strain Using 2D Speckle Tracking for Prediction of Adverse Events in Severe Asymptomatic Aortic Valve Stenosis." Journal of Cardiovascular Disease Research 12 (2021), 308-317. doi:10.31838/jcdr.2021.12.06.40



MLA (The Modern Language Association) Style

Ahmed Youssif Abd-Elkhalek, Hesham khaled Rasheed, Sahar Abdelaal Abdullah, Ahmed Yousuf Nammour. "Value of Global Left Ventricular Strain Using 2D Speckle Tracking for Prediction of Adverse Events in Severe Asymptomatic Aortic Valve Stenosis." Journal of Cardiovascular Disease Research 12.6 (2021), 308-317. Print. doi:10.31838/jcdr.2021.12.06.40



APA (American Psychological Association) Style

Ahmed Youssif Abd-Elkhalek, Hesham khaled Rasheed, Sahar Abdelaal Abdullah, Ahmed Yousuf Nammour (2021) Value of Global Left Ventricular Strain Using 2D Speckle Tracking for Prediction of Adverse Events in Severe Asymptomatic Aortic Valve Stenosis. Journal of Cardiovascular Disease Research, 12 (6), 308-317. doi:10.31838/jcdr.2021.12.06.40





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