E-ISSN 0976-2833 | ISSN 0975-3583
 

Research Article 


Formulation and Characterization In vitro Release of Topical Nanogel from Natural Source in the Management of Psoriasis.

Shivanshu Gangwar, Md.Semimul Akhtar.

Abstract
Combination of curcumin with anti-inflammatory drug like caffeine shows augmented antipsoriatic action com-pared to curcumin alone and reduce the time taken for treatment of Psoriasis. The objective of the present study was to develop nanosponge (NS) based topical gel of curcumin (CUR) and caffeine (CFN) combination that acts as a potential system for the treatment of psoriasis. NS composed of dimethyl carbonate (DMC) as crosslinker and beta- cyclodextrin (β- CD) as polymer were prepared by hot melt method and incorporated in topical gels. evaluation studies for NS and nanogels were conducted. Ex vivo animal studies were carried out for optimized formulation using mouse model of imiquimod- induced psoriasis. Results The physical and chemical characteristics exhibited by the prepared NS and gels (F1-F9) were found to be optimal. The optimization resulted in achieving formulation N10 with 69.72% in vitro drug release and 12,329.78cp viscosity. Histopathology studies revealed that prepared nanogel has promising anti- psoriatic activity. The results concluded that CUR and CFN combi-nation has reduced the time required for showing anti-psoriatic activity to 10 days when compared to CUR alone that took around 20 days. Moreover, the nanogel has depicted sustained drug release till 12 h. From the experimental findings it has been concluded that CUR and CFN combination significantly augmented the anti-psoriatic efficacy with respect to individual components and also reduced the time required for onset of effect. Thus, the proposed nanogel would be an imperative drug delivery system for more effective anti-psoriatic therapy.

Key words: Topical drug delivery . Nanosponges . Psoriasis . Curcumin . Caffeine . Topical gel . Imiquimod


 
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Pubmed Style

Shivanshu Gangwar, Md.Semimul Akhtar. Formulation and Characterization In vitro Release of Topical Nanogel from Natural Source in the Management of Psoriasis. . J Cardiovasc. Dis. Res.. 2022; 13(1): 45-62. doi:10.31838/jcdr.2022.13.01.05


Web Style

Shivanshu Gangwar, Md.Semimul Akhtar. Formulation and Characterization In vitro Release of Topical Nanogel from Natural Source in the Management of Psoriasis. . http://www.jcdronline.org/?mno=141357 [Access: January 15, 2022]. doi:10.31838/jcdr.2022.13.01.05


AMA (American Medical Association) Style

Shivanshu Gangwar, Md.Semimul Akhtar. Formulation and Characterization In vitro Release of Topical Nanogel from Natural Source in the Management of Psoriasis. . J Cardiovasc. Dis. Res.. 2022; 13(1): 45-62. doi:10.31838/jcdr.2022.13.01.05



Vancouver/ICMJE Style

Shivanshu Gangwar, Md.Semimul Akhtar. Formulation and Characterization In vitro Release of Topical Nanogel from Natural Source in the Management of Psoriasis. . J Cardiovasc. Dis. Res.. (2022), [cited January 15, 2022]; 13(1): 45-62. doi:10.31838/jcdr.2022.13.01.05



Harvard Style

Shivanshu Gangwar, Md.Semimul Akhtar (2022) Formulation and Characterization In vitro Release of Topical Nanogel from Natural Source in the Management of Psoriasis. . J Cardiovasc. Dis. Res., 13 (1), 45-62. doi:10.31838/jcdr.2022.13.01.05



Turabian Style

Shivanshu Gangwar, Md.Semimul Akhtar. 2022. Formulation and Characterization In vitro Release of Topical Nanogel from Natural Source in the Management of Psoriasis. . Journal of Cardiovascular Disease Research, 13 (1), 45-62. doi:10.31838/jcdr.2022.13.01.05



Chicago Style

Shivanshu Gangwar, Md.Semimul Akhtar. "Formulation and Characterization In vitro Release of Topical Nanogel from Natural Source in the Management of Psoriasis. ." Journal of Cardiovascular Disease Research 13 (2022), 45-62. doi:10.31838/jcdr.2022.13.01.05



MLA (The Modern Language Association) Style

Shivanshu Gangwar, Md.Semimul Akhtar. "Formulation and Characterization In vitro Release of Topical Nanogel from Natural Source in the Management of Psoriasis. ." Journal of Cardiovascular Disease Research 13.1 (2022), 45-62. Print. doi:10.31838/jcdr.2022.13.01.05



APA (American Psychological Association) Style

Shivanshu Gangwar, Md.Semimul Akhtar (2022) Formulation and Characterization In vitro Release of Topical Nanogel from Natural Source in the Management of Psoriasis. . Journal of Cardiovascular Disease Research, 13 (1), 45-62. doi:10.31838/jcdr.2022.13.01.05





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