E-ISSN 0976-2833 | ISSN 0975-3583
 

Research Article 


DEVELOPMENT AND VALIDATION OF SIMPLE SPECTROSCOPIC METHODS FOR THE ESTIMATION OF HEPATITIS-C DRUG DACLATASVIR DI HYDROCHLORIDE IN PURE FORM

T. Nagendra Kumar, K. Nagaraju, M. Eswar gupta.

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Abstract
Three simple, sensitive, rapid and accurate spectrophotometric methods have been proposed for the estimation of daclatsvir di hydrochloride (Dimethyl N,N'-([1,1'-biphenyl]-4,4'-diylbis{1H-imidazole-5,2-diyl-[(2S)-pyrrolidine-2,1-diyl][(2S)-3-methyl-1-oxobutane-1,2-diyl]})dicarbamate) in pure form. These methods were based on the measurement of absorbance of FC reagent [METHOD-A], Methyl orange [METHOD-B] and Cresol red [METHOD-C] at 553nm, 425nm and 432nm respectively. Reaction conditions have been optimized to obtain coloured complexes of higher sensitivity and longer stability. The absorbance increased linearly with increase in concentrations of daclatasvir.The complexes obeyed Beers law over the concentration range of 25 - 125 g/mL, 30 - 70 g/mL and 30 - 70 g/mL in method A, method B and method C respectively.The common excipients and additives did not interfere in their determination. The developed methods have been successfully applied for the estimation of daclatasvir in bulk samples.

Key words: Daclatasvir (DAC), Spectrophotometry, FC reagent, Methyl orange, Cresol red.


 
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Pubmed Style

T. Nagendra Kumar , K. Nagaraju, M. Eswar gupta. DEVELOPMENT AND VALIDATION OF SIMPLE SPECTROSCOPIC METHODS FOR THE ESTIMATION OF HEPATITIS-C DRUG DACLATASVIR DI HYDROCHLORIDE IN PURE FORM. J Cardiovasc. Dis. Res.. 2021; 12(4): 1315-1322. doi: 10.31838/jcdr.2021.12.03.147


Web Style

T. Nagendra Kumar , K. Nagaraju, M. Eswar gupta. DEVELOPMENT AND VALIDATION OF SIMPLE SPECTROSCOPIC METHODS FOR THE ESTIMATION OF HEPATITIS-C DRUG DACLATASVIR DI HYDROCHLORIDE IN PURE FORM. http://www.jcdronline.org/?mno=1442 [Access: December 04, 2021]. doi: 10.31838/jcdr.2021.12.03.147


AMA (American Medical Association) Style

T. Nagendra Kumar , K. Nagaraju, M. Eswar gupta. DEVELOPMENT AND VALIDATION OF SIMPLE SPECTROSCOPIC METHODS FOR THE ESTIMATION OF HEPATITIS-C DRUG DACLATASVIR DI HYDROCHLORIDE IN PURE FORM. J Cardiovasc. Dis. Res.. 2021; 12(4): 1315-1322. doi: 10.31838/jcdr.2021.12.03.147



Vancouver/ICMJE Style

T. Nagendra Kumar , K. Nagaraju, M. Eswar gupta. DEVELOPMENT AND VALIDATION OF SIMPLE SPECTROSCOPIC METHODS FOR THE ESTIMATION OF HEPATITIS-C DRUG DACLATASVIR DI HYDROCHLORIDE IN PURE FORM. J Cardiovasc. Dis. Res.. (2021), [cited December 04, 2021]; 12(4): 1315-1322. doi: 10.31838/jcdr.2021.12.03.147



Harvard Style

T. Nagendra Kumar , K. Nagaraju, M. Eswar gupta (2021) DEVELOPMENT AND VALIDATION OF SIMPLE SPECTROSCOPIC METHODS FOR THE ESTIMATION OF HEPATITIS-C DRUG DACLATASVIR DI HYDROCHLORIDE IN PURE FORM. J Cardiovasc. Dis. Res., 12 (4), 1315-1322. doi: 10.31838/jcdr.2021.12.03.147



Turabian Style

T. Nagendra Kumar , K. Nagaraju, M. Eswar gupta. 2021. DEVELOPMENT AND VALIDATION OF SIMPLE SPECTROSCOPIC METHODS FOR THE ESTIMATION OF HEPATITIS-C DRUG DACLATASVIR DI HYDROCHLORIDE IN PURE FORM. Journal of Cardiovascular Disease Research, 12 (4), 1315-1322. doi: 10.31838/jcdr.2021.12.03.147



Chicago Style

T. Nagendra Kumar , K. Nagaraju, M. Eswar gupta. "DEVELOPMENT AND VALIDATION OF SIMPLE SPECTROSCOPIC METHODS FOR THE ESTIMATION OF HEPATITIS-C DRUG DACLATASVIR DI HYDROCHLORIDE IN PURE FORM." Journal of Cardiovascular Disease Research 12 (2021), 1315-1322. doi: 10.31838/jcdr.2021.12.03.147



MLA (The Modern Language Association) Style

T. Nagendra Kumar , K. Nagaraju, M. Eswar gupta. "DEVELOPMENT AND VALIDATION OF SIMPLE SPECTROSCOPIC METHODS FOR THE ESTIMATION OF HEPATITIS-C DRUG DACLATASVIR DI HYDROCHLORIDE IN PURE FORM." Journal of Cardiovascular Disease Research 12.4 (2021), 1315-1322. Print. doi: 10.31838/jcdr.2021.12.03.147



APA (American Psychological Association) Style

T. Nagendra Kumar , K. Nagaraju, M. Eswar gupta (2021) DEVELOPMENT AND VALIDATION OF SIMPLE SPECTROSCOPIC METHODS FOR THE ESTIMATION OF HEPATITIS-C DRUG DACLATASVIR DI HYDROCHLORIDE IN PURE FORM. Journal of Cardiovascular Disease Research, 12 (4), 1315-1322. doi: 10.31838/jcdr.2021.12.03.147





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