E-ISSN 0976-2833 | ISSN 0975-3583
 

Research Article 


IN SILICO DESIGNING AND ANALYSIS OF INHIBITORS AGAINST TARGET PROTEIN OF MALARIA

Nainshi Omar, Preeti Verma, Abhinav Prasoon Mishra, Bhupendra Chauhan, Suyash Gupta, Riya Mathur.

Cited by (4)

Abstract
Malaria, initiated by apicomplexan parasite, is an old disease and continues to be a major public health threat in many countries. This article aims to present different aspects of malaria including causes, pathogenesis, prevention, and treatment in an articulate and comprehensive manner and it causes high levels of morbidity and mortality in human beings worldwide. The development of new molecular tools as well as the use of next-generation sequencing (NGS) technologies and novel bioinformatics approaches has improved our knowledge of malarial epidemiology, diagnosis, treatment, vaccine development, and surveillance strategies.The Plasmodium falciparum is the most dangerous species that can infect human. The enzyme hypoxanthine-guanine phosphorybosyltransferase (HGPRT) in the malarial parasite Plasmodium falciparum (Pf) is central to the salvage pathway for purine nucleotide biosynthesis and is a potential antimalarial chemotherapeutic target. As with all metabolic pathways, serious problems occur if steps in the pathway are blocked. Some people inherit a rare defective version of HGPRT, which leads to a serious illness termed Lesch-Nyhan syndrome. Vector and parasite drug resistance are two major challenges for malaria control that require special attention. Artemisinins are sesquiterpene lactones, and has been recently approved for the treatment of malaria due to its endoperoxidase properties. This approach also estimates the ligand-receptor binding free energy by evaluating critical phenomena involved in the intermolecular recognition process. Prodrugs of these compounds have IC50 values in the 4-6 mM range in antimalarial cellbased assays, making them attractive compounds for further development as antimalarial drug leads. The purpose of this review is to examine current molecular docking strategies used in drug discovery and medicinal chemistry, exploring the advances in the field and the role played by the integration of structure- and ligand-based methods.

Key words: Malaria,plasmodium falciparum, HGPRT, molecular docking,purine, pyrimidine nucleosides


 
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PMid:18046154

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Nainshi Omar, Preeti Verma, Abhinav Prasoon Mishra, Bhupendra Chauhan, Suyash Gupta, Riya Mathur. IN SILICO DESIGNING AND ANALYSIS OF INHIBITORS AGAINST TARGET PROTEIN OF MALARIA. J Cardiovasc. Dis. Res.. 2021; 12(3): 2882-2895. doi:10.31838/jcdr.2021.12.03.374


Web Style

Nainshi Omar, Preeti Verma, Abhinav Prasoon Mishra, Bhupendra Chauhan, Suyash Gupta, Riya Mathur. IN SILICO DESIGNING AND ANALYSIS OF INHIBITORS AGAINST TARGET PROTEIN OF MALARIA. http://www.jcdronline.org/?mno=15345 [Access: December 04, 2021]. doi:10.31838/jcdr.2021.12.03.374


AMA (American Medical Association) Style

Nainshi Omar, Preeti Verma, Abhinav Prasoon Mishra, Bhupendra Chauhan, Suyash Gupta, Riya Mathur. IN SILICO DESIGNING AND ANALYSIS OF INHIBITORS AGAINST TARGET PROTEIN OF MALARIA. J Cardiovasc. Dis. Res.. 2021; 12(3): 2882-2895. doi:10.31838/jcdr.2021.12.03.374



Vancouver/ICMJE Style

Nainshi Omar, Preeti Verma, Abhinav Prasoon Mishra, Bhupendra Chauhan, Suyash Gupta, Riya Mathur. IN SILICO DESIGNING AND ANALYSIS OF INHIBITORS AGAINST TARGET PROTEIN OF MALARIA. J Cardiovasc. Dis. Res.. (2021), [cited December 04, 2021]; 12(3): 2882-2895. doi:10.31838/jcdr.2021.12.03.374



Harvard Style

Nainshi Omar, Preeti Verma, Abhinav Prasoon Mishra, Bhupendra Chauhan, Suyash Gupta, Riya Mathur (2021) IN SILICO DESIGNING AND ANALYSIS OF INHIBITORS AGAINST TARGET PROTEIN OF MALARIA. J Cardiovasc. Dis. Res., 12 (3), 2882-2895. doi:10.31838/jcdr.2021.12.03.374



Turabian Style

Nainshi Omar, Preeti Verma, Abhinav Prasoon Mishra, Bhupendra Chauhan, Suyash Gupta, Riya Mathur. 2021. IN SILICO DESIGNING AND ANALYSIS OF INHIBITORS AGAINST TARGET PROTEIN OF MALARIA. Journal of Cardiovascular Disease Research, 12 (3), 2882-2895. doi:10.31838/jcdr.2021.12.03.374



Chicago Style

Nainshi Omar, Preeti Verma, Abhinav Prasoon Mishra, Bhupendra Chauhan, Suyash Gupta, Riya Mathur. "IN SILICO DESIGNING AND ANALYSIS OF INHIBITORS AGAINST TARGET PROTEIN OF MALARIA." Journal of Cardiovascular Disease Research 12 (2021), 2882-2895. doi:10.31838/jcdr.2021.12.03.374



MLA (The Modern Language Association) Style

Nainshi Omar, Preeti Verma, Abhinav Prasoon Mishra, Bhupendra Chauhan, Suyash Gupta, Riya Mathur. "IN SILICO DESIGNING AND ANALYSIS OF INHIBITORS AGAINST TARGET PROTEIN OF MALARIA." Journal of Cardiovascular Disease Research 12.3 (2021), 2882-2895. Print. doi:10.31838/jcdr.2021.12.03.374



APA (American Psychological Association) Style

Nainshi Omar, Preeti Verma, Abhinav Prasoon Mishra, Bhupendra Chauhan, Suyash Gupta, Riya Mathur (2021) IN SILICO DESIGNING AND ANALYSIS OF INHIBITORS AGAINST TARGET PROTEIN OF MALARIA. Journal of Cardiovascular Disease Research, 12 (3), 2882-2895. doi:10.31838/jcdr.2021.12.03.374





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