E-ISSN 0976-2833 | ISSN 0975-3583
 

Original Research 


Assessment of Nitric Oxide and Oxidized LDL associated with low grade inflammation; A Non-Invasive Risk Predictor of Coronary Heart Disease

Thirunavukkarasu Jaishankar, Meera Shivasekar, Vinodhini V.M.

Abstract
Coronary Heart Disease arises when cholesterol carried in blood form plaque in the covering of coronary arteries lead to atherosclerosis. The diminished nitric oxide production and inflammation involved in the development of atherosclerosis. The pathogenesis of atherosclerosis are implicated by decreased availability of nitric oxide. Reduced NO level in the endothelium makes it vulnerable and increase the passage of leukocyte and LDL oxidation in the sub endothelial space which ultimately lead to coronary heart disease. Our objective of the study is to evaluate the association of NO and ox-LDL along with hs-CRP in subjects with coronary heart disease. This cross-sectional study showed that the mean Nitric Oxide levels were decreased significantly in CHD group compared to controls. Significant increase in Oxidized LDL and hs-CRP showed in CHD group when compared to controls. Increased oxidative stress associated with diminished bioavailability of nitric oxide undergo oxidative modification of LDL lead to low grade inflammation

Key words: Coronary Heart Disease, High Density Lipoprotein, High sensitive C- reactive protein, Low Density Lipoprotein, Nitric Oxide, Oxidized Low Density Lipoprotein.


 
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How to Cite this Article
Pubmed Style

Jaishankar T, Shivasekar M, V.M V. Assessment of Nitric Oxide and Oxidized LDL associated with low grade inflammation; A Non-Invasive Risk Predictor of Coronary Heart Disease. . 2021; 12(1): 49-54. doi:10.31838/jcdr.2021.12.01.12


Web Style

Jaishankar T, Shivasekar M, V.M V. Assessment of Nitric Oxide and Oxidized LDL associated with low grade inflammation; A Non-Invasive Risk Predictor of Coronary Heart Disease. http://www.jcdronline.org//?mno=26470 [Access: April 12, 2021]. doi:10.31838/jcdr.2021.12.01.12


AMA (American Medical Association) Style

Jaishankar T, Shivasekar M, V.M V. Assessment of Nitric Oxide and Oxidized LDL associated with low grade inflammation; A Non-Invasive Risk Predictor of Coronary Heart Disease. . 2021; 12(1): 49-54. doi:10.31838/jcdr.2021.12.01.12



Vancouver/ICMJE Style

Jaishankar T, Shivasekar M, V.M V. Assessment of Nitric Oxide and Oxidized LDL associated with low grade inflammation; A Non-Invasive Risk Predictor of Coronary Heart Disease. . (2021), [cited April 12, 2021]; 12(1): 49-54. doi:10.31838/jcdr.2021.12.01.12



Harvard Style

Jaishankar, T., Shivasekar, . M. & V.M, . V. (2021) Assessment of Nitric Oxide and Oxidized LDL associated with low grade inflammation; A Non-Invasive Risk Predictor of Coronary Heart Disease. , 12 (1), 49-54. doi:10.31838/jcdr.2021.12.01.12



Turabian Style

Jaishankar, Thirunavukkarasu, Meera Shivasekar, and Vinodhini V.M. 2021. Assessment of Nitric Oxide and Oxidized LDL associated with low grade inflammation; A Non-Invasive Risk Predictor of Coronary Heart Disease. Journal of Cardiovascular Disease Research, 12 (1), 49-54. doi:10.31838/jcdr.2021.12.01.12



Chicago Style

Jaishankar, Thirunavukkarasu, Meera Shivasekar, and Vinodhini V.M. "Assessment of Nitric Oxide and Oxidized LDL associated with low grade inflammation; A Non-Invasive Risk Predictor of Coronary Heart Disease." Journal of Cardiovascular Disease Research 12 (2021), 49-54. doi:10.31838/jcdr.2021.12.01.12



MLA (The Modern Language Association) Style

Jaishankar, Thirunavukkarasu, Meera Shivasekar, and Vinodhini V.M. "Assessment of Nitric Oxide and Oxidized LDL associated with low grade inflammation; A Non-Invasive Risk Predictor of Coronary Heart Disease." Journal of Cardiovascular Disease Research 12.1 (2021), 49-54. Print. doi:10.31838/jcdr.2021.12.01.12



APA (American Psychological Association) Style

Jaishankar, T., Shivasekar, . M. & V.M, . V. (2021) Assessment of Nitric Oxide and Oxidized LDL associated with low grade inflammation; A Non-Invasive Risk Predictor of Coronary Heart Disease. Journal of Cardiovascular Disease Research, 12 (1), 49-54. doi:10.31838/jcdr.2021.12.01.12