E-ISSN 0976-2833 | ISSN 0975-3583
 

Original Article 


Lipoprotein (a) and its Correlation to Free Radical Nitric Oxide in Coronary Heart Disease subjects

Thirunavukkarasu Jaishankar, Meera Shivasekar, Vinodhini V.M.

Abstract
Lipoprotein (a) is comprised of low-density lipoprotein cholesterol which promote endothelial cell dysfunction and impair the effect of vasodilation by reducing the availability of nitric oxide by inhibiting the expression of eNOS. Higher Lipoprotein (a) levels are linked with an increased risk of coronary heart disease. The aim of the study is to find the association between Lipoprotein (a) and nitric oxide levels in coronary heart disease. After overnight fasting blood samples were collected for analysis for Lipid Profile and Nitric oxide. Nitric Oxide and Lipoprotein (a) measured by ELISA method and Lipid Profile is measured using Auto Analyser AU480. Statistical analysis was done using Student t test and Pearson correlation analysis for the comparison between two groups. The mean level of Low Density Lipoprotein level and Lipoprotein (a) in CHD was elevated and statistically significant (p-value <0.001) compared to the normal healthy controls. And the mean Nitric Oxide levels were decreased significantly in CHD group compared to controls. Lipoprotein (a) plays a major role in the progression of Coronary heart disease cascade. Increased level of Lipoprotein (a) associated with an increased risk of CHD and myocardial infarction.

Key words: Coronary Heart Disease, High Density Lipoprotein, Intermediate Density Lipoprotein, Low Density Lipoprotein, Lipoprotein, Lipoprotein (a) and Nitric Oxide.


 
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How to Cite this Article
Pubmed Style

Jaishankar T, Shivasekar M, V.M V, . Lipoprotein (a) and its Correlation to Free Radical Nitric Oxide in Coronary Heart Disease subjects. . 2021; 12(1): 13-18. doi:10.31838/jcdr.2021.12.01.04


Web Style

Jaishankar T, Shivasekar M, V.M V, . Lipoprotein (a) and its Correlation to Free Radical Nitric Oxide in Coronary Heart Disease subjects. http://www.jcdronline.org//?mno=28106 [Access: April 12, 2021]. doi:10.31838/jcdr.2021.12.01.04


AMA (American Medical Association) Style

Jaishankar T, Shivasekar M, V.M V, . Lipoprotein (a) and its Correlation to Free Radical Nitric Oxide in Coronary Heart Disease subjects. . 2021; 12(1): 13-18. doi:10.31838/jcdr.2021.12.01.04



Vancouver/ICMJE Style

Jaishankar T, Shivasekar M, V.M V, . Lipoprotein (a) and its Correlation to Free Radical Nitric Oxide in Coronary Heart Disease subjects. . (2021), [cited April 12, 2021]; 12(1): 13-18. doi:10.31838/jcdr.2021.12.01.04



Harvard Style

Jaishankar, T., Shivasekar, M., V.M, V. & (2021) Lipoprotein (a) and its Correlation to Free Radical Nitric Oxide in Coronary Heart Disease subjects. , 12 (1), 13-18. doi:10.31838/jcdr.2021.12.01.04



Turabian Style

Jaishankar, Thirunavukkarasu, Meera Shivasekar, Vinodhini V.M, and . 2021. Lipoprotein (a) and its Correlation to Free Radical Nitric Oxide in Coronary Heart Disease subjects. Journal of Cardiovascular Disease Research, 12 (1), 13-18. doi:10.31838/jcdr.2021.12.01.04



Chicago Style

Jaishankar, Thirunavukkarasu, Meera Shivasekar, Vinodhini V.M, and . "Lipoprotein (a) and its Correlation to Free Radical Nitric Oxide in Coronary Heart Disease subjects." Journal of Cardiovascular Disease Research 12 (2021), 13-18. doi:10.31838/jcdr.2021.12.01.04



MLA (The Modern Language Association) Style

Jaishankar, Thirunavukkarasu, Meera Shivasekar, Vinodhini V.M, and . "Lipoprotein (a) and its Correlation to Free Radical Nitric Oxide in Coronary Heart Disease subjects." Journal of Cardiovascular Disease Research 12.1 (2021), 13-18. Print. doi:10.31838/jcdr.2021.12.01.04



APA (American Psychological Association) Style

Jaishankar, T., Shivasekar, M., V.M, V. & (2021) Lipoprotein (a) and its Correlation to Free Radical Nitric Oxide in Coronary Heart Disease subjects. Journal of Cardiovascular Disease Research, 12 (1), 13-18. doi:10.31838/jcdr.2021.12.01.04