E-ISSN 0976-2833 | ISSN 0975-3583
 

Original Research 


A Prospective Analytical Research to Evaluate the Expenses and Benefits of Procalcitonin Testing in the Diagnosis of Early Onset Neonatal Sepsis

Dr. Sanjay Kumar.

Abstract
Aim: To compare between the expenses and benefits of procalcitonin testing in the diagnosis
of early onset neonatal sepsis.
Methods: This prospective analytical study was carried out in the Department of Paediatrics,
Visakha Steel General Hospital Visakhapatnam, Andhra Pradesh, India for 15 months. 100
Full-term neonates (>37 weeks gestational age) admitted to NICU with the clinical
symptoms or signs of sepsis within 72 h of birth, and those with risk factors for EONS.
For all patients included in the study, complete blood count with differential (CBC), CRP,
blood culture, procalcitonin was done on admission to NICU, and was repeated after 8 hours
from the initial one, while CRP was repeated after 24 hrs. Cultures from other sites (including
CSF), chest x ray and imaging were done as appropriate.
Results: Their mean weight was 3.213 kg (range 2.2- 4.8 kg). Mean age of presentation was
14 hours (range 2-68) hours. About 90 (90 %) patients presented with more than one symptoms
and signs of sepsis For CBC results, mean WBC count was 19.8 9.1, the mean neutrophils
count was 15.55 10.57) and the mean platelet count was 171.2169.21. This study includes
neonates with early onset sepsis. In the present study the most frequent presenting sign was
hypothermia (63%), hypo activity and mottling (54%), followed by feeding intolerance
(43%). Blood cultures were positive in 37 patients, who compromised the group of proven
sepsis. Klebsiella was present in 14 patient, E coli in 10 patients, while group B streptococcus
in 8 patients. Pseudomonas infection present in 3 patients, while MRSA (methicillin resistant
staphylococcus aureus) was detected in 2 patients. The initial CRP (CRP1) , was non-reactive
in 42 patients (42%), The initial procalcitonin in the sepsis group (PCT1), was non-reactive 42
patients (42%) , <2.6 in 32 patients (32%), 2.6-10 in 20 patients (20%), and more than that in
6 patients (6%). Sensitivity= 93.5%, Specificity=54%, PPV= 66.3%, NPV= 87.5%. PCT2:
Sensitivity=96.8%, Specificity=88.7%, PPV=91.1%, NPV=99%.
Conclusion: The expense of testing PCT twice is less than the expenses of one-day admission
in NICU in developing countries. Application of such protocol could be of use in limiting
period of stay in NICU.

Key words: NICU, Procalcitonin, Early Onset Neonatal


 
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Pubmed Style

Dr. Sanjay Kumar. A Prospective Analytical Research to Evaluate the Expenses and Benefits of Procalcitonin Testing in the Diagnosis of Early Onset Neonatal Sepsis. J Cardiovasc. Dis. Res.. 2021; 12(6): 517-524. doi:10.31838/jcdr.2021.12.06.69


Web Style

Dr. Sanjay Kumar. A Prospective Analytical Research to Evaluate the Expenses and Benefits of Procalcitonin Testing in the Diagnosis of Early Onset Neonatal Sepsis. http://www.jcdronline.org/?mno=29303 [Access: January 16, 2022]. doi:10.31838/jcdr.2021.12.06.69


AMA (American Medical Association) Style

Dr. Sanjay Kumar. A Prospective Analytical Research to Evaluate the Expenses and Benefits of Procalcitonin Testing in the Diagnosis of Early Onset Neonatal Sepsis. J Cardiovasc. Dis. Res.. 2021; 12(6): 517-524. doi:10.31838/jcdr.2021.12.06.69



Vancouver/ICMJE Style

Dr. Sanjay Kumar. A Prospective Analytical Research to Evaluate the Expenses and Benefits of Procalcitonin Testing in the Diagnosis of Early Onset Neonatal Sepsis. J Cardiovasc. Dis. Res.. (2021), [cited January 16, 2022]; 12(6): 517-524. doi:10.31838/jcdr.2021.12.06.69



Harvard Style

Dr. Sanjay Kumar (2021) A Prospective Analytical Research to Evaluate the Expenses and Benefits of Procalcitonin Testing in the Diagnosis of Early Onset Neonatal Sepsis. J Cardiovasc. Dis. Res., 12 (6), 517-524. doi:10.31838/jcdr.2021.12.06.69



Turabian Style

Dr. Sanjay Kumar. 2021. A Prospective Analytical Research to Evaluate the Expenses and Benefits of Procalcitonin Testing in the Diagnosis of Early Onset Neonatal Sepsis. Journal of Cardiovascular Disease Research, 12 (6), 517-524. doi:10.31838/jcdr.2021.12.06.69



Chicago Style

Dr. Sanjay Kumar. "A Prospective Analytical Research to Evaluate the Expenses and Benefits of Procalcitonin Testing in the Diagnosis of Early Onset Neonatal Sepsis." Journal of Cardiovascular Disease Research 12 (2021), 517-524. doi:10.31838/jcdr.2021.12.06.69



MLA (The Modern Language Association) Style

Dr. Sanjay Kumar. "A Prospective Analytical Research to Evaluate the Expenses and Benefits of Procalcitonin Testing in the Diagnosis of Early Onset Neonatal Sepsis." Journal of Cardiovascular Disease Research 12.6 (2021), 517-524. Print. doi:10.31838/jcdr.2021.12.06.69



APA (American Psychological Association) Style

Dr. Sanjay Kumar (2021) A Prospective Analytical Research to Evaluate the Expenses and Benefits of Procalcitonin Testing in the Diagnosis of Early Onset Neonatal Sepsis. Journal of Cardiovascular Disease Research, 12 (6), 517-524. doi:10.31838/jcdr.2021.12.06.69





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