E-ISSN 0976-2833 | ISSN 0975-3583
 

Original Research 


The effect of smoking on angiotensin converting enzyme and its relation with severity of cardiovascular disease in young smokers

dinesh nath, meera shivasekar, VM Vinodhini.

Abstract
Smoking is considered as a significant risk factor of cardiovascular disease (CVD). However, the mechanisms by which it causes CVDs are not clear. Angiotensin-converting enzyme (ACE) is a key enzyme in the rennin-angiotensin-aldosterone system, converting angiotensin I to the angiotensin II, which regulates blood pressure and act as a vasoconstrictor may plays a vital role in cardiovascular disease. So the aim of this study to find out the potential association between ACE and smoking and its relation with the severity of cardiovascular disease in young smokers. The study comprise 60 young smokers with CHD aged between 20 to 45 years, and 60 healthy non smoker were included as a control who were attending in Cardiology OP, Medicine OP and MHC was selected for the study. Serum ACE, APO-E and hsCRP levels were measured by Enzyme-linked Immune Sorbent Assay (ELISA) and lipid profile was measured by enzymatic method. The mean serum ACE, APO-E and hsCRP levels were significantly (p value <0.0001) higher in smokers with CHD when compared to the controls. A significant positive correlation was found between ACE and APO-E (r-value=0.3776), hsCRP (r-value=0.4614 ), W/H ratio (r-value=0.4673), TC (r-value=0.4858), TGL (r-value=0.3917), LDL (r-value=0.4689), TC/HDL (r-value=0.3225) and HDL/LDL (r-value=0.3638). Our study also shows a significant positive correlation between serum ACE, APO-E and hsCRP levels with different age group, duration of smoking and number of smoking per day in young smokers. This study concludes that smoking produced a major effect on serum ACE, APO-E and hsCRP levels and is notably linked with the severity of coronary heart disease in young smokers.

Key words: young smoker, smoking, Anginotensin converting enzyme, cardiovascular disease, rennin angiotensin system


 
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How to Cite this Article
Pubmed Style

nath d, shivasekar m, Vinodhini V. The effect of smoking on angiotensin converting enzyme and its relation with severity of cardiovascular disease in young smokers. . 2021; 12(1): 110-116. doi:10.31838/jcdr.2021.12.01.15


Web Style

nath d, shivasekar m, Vinodhini V. The effect of smoking on angiotensin converting enzyme and its relation with severity of cardiovascular disease in young smokers. http://www.jcdronline.org//?mno=40883 [Access: April 30, 2021]. doi:10.31838/jcdr.2021.12.01.15


AMA (American Medical Association) Style

nath d, shivasekar m, Vinodhini V. The effect of smoking on angiotensin converting enzyme and its relation with severity of cardiovascular disease in young smokers. . 2021; 12(1): 110-116. doi:10.31838/jcdr.2021.12.01.15



Vancouver/ICMJE Style

nath d, shivasekar m, Vinodhini V. The effect of smoking on angiotensin converting enzyme and its relation with severity of cardiovascular disease in young smokers. . (2021), [cited April 30, 2021]; 12(1): 110-116. doi:10.31838/jcdr.2021.12.01.15



Harvard Style

nath, d., shivasekar, . m. & Vinodhini, . V. (2021) The effect of smoking on angiotensin converting enzyme and its relation with severity of cardiovascular disease in young smokers. , 12 (1), 110-116. doi:10.31838/jcdr.2021.12.01.15



Turabian Style

nath, dinesh, meera shivasekar, and VM Vinodhini. 2021. The effect of smoking on angiotensin converting enzyme and its relation with severity of cardiovascular disease in young smokers. Journal of Cardiovascular Disease Research, 12 (1), 110-116. doi:10.31838/jcdr.2021.12.01.15



Chicago Style

nath, dinesh, meera shivasekar, and VM Vinodhini. "The effect of smoking on angiotensin converting enzyme and its relation with severity of cardiovascular disease in young smokers." Journal of Cardiovascular Disease Research 12 (2021), 110-116. doi:10.31838/jcdr.2021.12.01.15



MLA (The Modern Language Association) Style

nath, dinesh, meera shivasekar, and VM Vinodhini. "The effect of smoking on angiotensin converting enzyme and its relation with severity of cardiovascular disease in young smokers." Journal of Cardiovascular Disease Research 12.1 (2021), 110-116. Print. doi:10.31838/jcdr.2021.12.01.15



APA (American Psychological Association) Style

nath, d., shivasekar, . m. & Vinodhini, . V. (2021) The effect of smoking on angiotensin converting enzyme and its relation with severity of cardiovascular disease in young smokers. Journal of Cardiovascular Disease Research, 12 (1), 110-116. doi:10.31838/jcdr.2021.12.01.15