E-ISSN 0976-2833 | ISSN 0975-3583
 

Research Article 


Effects of Remnant Lipoprotein Cholesterol Associated With Nitric Oxide in Diabetic and Non- Diabetic Subjects; An Risk Predictor for Future Coronary Heart Disease

Thirunavukkarasu Jaishankar, Meera Shivasekar, Vinodhini V.M.

Abstract
Coronary Heart Disease is a multifactorial disease playing a crucial role in genetic and environmental aspects. The early incident in the development of atherosclerosis caused due to injury in the arterial wall through several mechanisms lead to endothelial dysfunction. The mechanisms involved include infection, free radicals, toxins and physical stresses occur with high blood pressure and blood lipid levels. Remnant lipoproteins, called β-VLDL, contain triglyceride and cholesterol rich constituent. Chylomicron remnants enter the arterial wall and engaged in the sub endothelial space. After injury to the wall, it may be possible for remnant lipoprotein particles larger than LDL enter in the vascular wall and cause atherosclerosis. Nitric oxide biosynthesis cause endothelial dysfunction. The aim of the study is to assess the role of remnant lipoprotein cholesterol associated with nitric oxide in non- diabetic subjects in the development of coronary heart disease. This cross-sectional study was conducted in SRM Medical college Hospital and Research center on subjects appearing the master health check-up and medicine OP. The study was conducted on 97 CHD patient, 97 CHD subject with Diabetes and 97 healthy control in age group of 25 to 55 years and were age and sex matched. After overnight fasting body fluid samples were collected for analysis for Lipid Profile, Nitric oxide measured by ELISA method and Lipid Profile is measured using Auto Analyzer AU480. Statistical analysis was done using Student‘t’ test and Pearson correlation analysis for the comparison between two groups. The mean Low Density Lipoprotein level in CHD was elevated (189.4±27.46) and statistically significant (p-value <0.001) compared to the normal healthy controls (106.4±12.59). And the mean Nitric Oxide levels were decreased (12.97± 1.20) significantly in CHD group compared to controls (19.08±4.74) (p <0.001). RLP-C showed significant increase (35.65±16.11) in CHD group when compared to controls (15.69±12.15) (p <0.001). Remnant lipoproteins contribute to form atherosclerotic lesions, RLP-cholesterol predict the risk of coronary heart disease and there is a strong association between NO and RLP-cholesterol associated with the severity in the development of CHD

Key words: Coronary Heart Disease, High Density Lipoprotein, Low Density Lipoprotein, Nitric Oxide, Remnant lipoprotein cholesterol


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Thirunavukkarasu Jaishankar
Articles by Meera Shivasekar
Articles by Vinodhini V.M
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Jaishankar T, Shivasekar M, V.M V. Effects of Remnant Lipoprotein Cholesterol Associated With Nitric Oxide in Diabetic and Non- Diabetic Subjects; An Risk Predictor for Future Coronary Heart Disease. . 2021; 12(1): 97-104. doi:10.31838/jcdr.2021.12.01.17


Web Style

Jaishankar T, Shivasekar M, V.M V. Effects of Remnant Lipoprotein Cholesterol Associated With Nitric Oxide in Diabetic and Non- Diabetic Subjects; An Risk Predictor for Future Coronary Heart Disease. http://www.jcdronline.org//?mno=4155 [Access: April 26, 2021]. doi:10.31838/jcdr.2021.12.01.17


AMA (American Medical Association) Style

Jaishankar T, Shivasekar M, V.M V. Effects of Remnant Lipoprotein Cholesterol Associated With Nitric Oxide in Diabetic and Non- Diabetic Subjects; An Risk Predictor for Future Coronary Heart Disease. . 2021; 12(1): 97-104. doi:10.31838/jcdr.2021.12.01.17



Vancouver/ICMJE Style

Jaishankar T, Shivasekar M, V.M V. Effects of Remnant Lipoprotein Cholesterol Associated With Nitric Oxide in Diabetic and Non- Diabetic Subjects; An Risk Predictor for Future Coronary Heart Disease. . (2021), [cited April 26, 2021]; 12(1): 97-104. doi:10.31838/jcdr.2021.12.01.17



Harvard Style

Jaishankar, T., Shivasekar, . M. & V.M, . V. (2021) Effects of Remnant Lipoprotein Cholesterol Associated With Nitric Oxide in Diabetic and Non- Diabetic Subjects; An Risk Predictor for Future Coronary Heart Disease. , 12 (1), 97-104. doi:10.31838/jcdr.2021.12.01.17



Turabian Style

Jaishankar, Thirunavukkarasu, Meera Shivasekar, and Vinodhini V.M. 2021. Effects of Remnant Lipoprotein Cholesterol Associated With Nitric Oxide in Diabetic and Non- Diabetic Subjects; An Risk Predictor for Future Coronary Heart Disease. Journal of Cardiovascular Disease Research, 12 (1), 97-104. doi:10.31838/jcdr.2021.12.01.17



Chicago Style

Jaishankar, Thirunavukkarasu, Meera Shivasekar, and Vinodhini V.M. "Effects of Remnant Lipoprotein Cholesterol Associated With Nitric Oxide in Diabetic and Non- Diabetic Subjects; An Risk Predictor for Future Coronary Heart Disease." Journal of Cardiovascular Disease Research 12 (2021), 97-104. doi:10.31838/jcdr.2021.12.01.17



MLA (The Modern Language Association) Style

Jaishankar, Thirunavukkarasu, Meera Shivasekar, and Vinodhini V.M. "Effects of Remnant Lipoprotein Cholesterol Associated With Nitric Oxide in Diabetic and Non- Diabetic Subjects; An Risk Predictor for Future Coronary Heart Disease." Journal of Cardiovascular Disease Research 12.1 (2021), 97-104. Print. doi:10.31838/jcdr.2021.12.01.17



APA (American Psychological Association) Style

Jaishankar, T., Shivasekar, . M. & V.M, . V. (2021) Effects of Remnant Lipoprotein Cholesterol Associated With Nitric Oxide in Diabetic and Non- Diabetic Subjects; An Risk Predictor for Future Coronary Heart Disease. Journal of Cardiovascular Disease Research, 12 (1), 97-104. doi:10.31838/jcdr.2021.12.01.17