E-ISSN 0976-2833 | ISSN 0975-3583
 

Original Article 


THE ANTI-ATHEROSCLEROSIS ACTIVITY OF FUCOIDAN CRUDE EXTRACT FROM SARGASSUM CRASSIFOLIUM

Syamsudin Abdillah, Pangartika Hikariastri, J.I. Adriana Purukan, Ayu Werawati, Esti Mumpuni, Dian Ratih Laksmitawati1,Hendig Winarno, Kusmardi.

Abstract
This purpose of this research is to examine the anti-atherosclerosis activity of Sargassum crassifolium brown algae in mouse, which was administered high-fat diet, and further examining the molecular mechanism of action, through the anti-inflammation test at RAW cell 264.7, inducted by lipopolysaccharide. Sargassum crassifolium was collected from Garut water, extracted by acid solvent, condensed with ethanol, and freeze-dried till the fucoidan crude extract was obtained. However, the mouse was dosed at 50, 100, and 200 mg/kg, after a high-fat diet, therefore, the blood lipid profile and abdominals aortae artery insulation were measured to calculate the amount of foam cell and the aortae thickness respectively. Furthermore, fucoidan crude extract was tested at RAW cell 264.7, which was inducted by LPS, at doses of 25 and 50 μg/ml, in order to observe its activity, toward the TNF-α, IL-1β, IL-6, VCAM-1, and ICAM-1, measured using ELISA. Hence, the isolate was proven to have atherosclerosis protective effect, through the improvement of blood lipid profile and the reduction of the foam cells, as well as the thickness of abdominal aortae. Furthermore, fucoidan crude extract obstructed the redemption of TNF-α, IL-1β, IL-6, VCAM-1, and ICAM-1 in vitro, therefore demonstrating that its activity was through the inflammation redemption response from Sargassum crassifolium.

Key words: Atherosclerosis; Fucoidan crude extract; Inflammation; Sargassum crassifolium


 
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How to Cite this Article
Pubmed Style

Syamsudin Abdillah, Pangartika Hikariastri, J.I. Adriana Purukan, Ayu Werawati, Esti Mumpuni, Dian Ratih Laksmitawati,Hendig Winarno, Kusmardi. THE ANTI-ATHEROSCLEROSIS ACTIVITY OF FUCOIDAN CRUDE EXTRACT FROM SARGASSUM CRASSIFOLIUM . J Cardiovasc. Dis. Res.. 2021; 12(3): 147-153. doi:10.31838/jcdr.2021.12.03.20


Web Style

Syamsudin Abdillah, Pangartika Hikariastri, J.I. Adriana Purukan, Ayu Werawati, Esti Mumpuni, Dian Ratih Laksmitawati,Hendig Winarno, Kusmardi. THE ANTI-ATHEROSCLEROSIS ACTIVITY OF FUCOIDAN CRUDE EXTRACT FROM SARGASSUM CRASSIFOLIUM . http://www.jcdronline.org/?mno=81498 [Access: May 23, 2021]. doi:10.31838/jcdr.2021.12.03.20


AMA (American Medical Association) Style

Syamsudin Abdillah, Pangartika Hikariastri, J.I. Adriana Purukan, Ayu Werawati, Esti Mumpuni, Dian Ratih Laksmitawati,Hendig Winarno, Kusmardi. THE ANTI-ATHEROSCLEROSIS ACTIVITY OF FUCOIDAN CRUDE EXTRACT FROM SARGASSUM CRASSIFOLIUM . J Cardiovasc. Dis. Res.. 2021; 12(3): 147-153. doi:10.31838/jcdr.2021.12.03.20



Vancouver/ICMJE Style

Syamsudin Abdillah, Pangartika Hikariastri, J.I. Adriana Purukan, Ayu Werawati, Esti Mumpuni, Dian Ratih Laksmitawati,Hendig Winarno, Kusmardi. THE ANTI-ATHEROSCLEROSIS ACTIVITY OF FUCOIDAN CRUDE EXTRACT FROM SARGASSUM CRASSIFOLIUM . J Cardiovasc. Dis. Res.. (2021), [cited May 23, 2021]; 12(3): 147-153. doi:10.31838/jcdr.2021.12.03.20



Harvard Style

Syamsudin Abdillah, Pangartika Hikariastri, J.I. Adriana Purukan, Ayu Werawati, Esti Mumpuni, Dian Ratih Laksmitawati,Hendig Winarno, Kusmardi (2021) THE ANTI-ATHEROSCLEROSIS ACTIVITY OF FUCOIDAN CRUDE EXTRACT FROM SARGASSUM CRASSIFOLIUM . J Cardiovasc. Dis. Res., 12 (3), 147-153. doi:10.31838/jcdr.2021.12.03.20



Turabian Style

Syamsudin Abdillah, Pangartika Hikariastri, J.I. Adriana Purukan, Ayu Werawati, Esti Mumpuni, Dian Ratih Laksmitawati,Hendig Winarno, Kusmardi. 2021. THE ANTI-ATHEROSCLEROSIS ACTIVITY OF FUCOIDAN CRUDE EXTRACT FROM SARGASSUM CRASSIFOLIUM . Journal of Cardiovascular Disease Research, 12 (3), 147-153. doi:10.31838/jcdr.2021.12.03.20



Chicago Style

Syamsudin Abdillah, Pangartika Hikariastri, J.I. Adriana Purukan, Ayu Werawati, Esti Mumpuni, Dian Ratih Laksmitawati,Hendig Winarno, Kusmardi. "THE ANTI-ATHEROSCLEROSIS ACTIVITY OF FUCOIDAN CRUDE EXTRACT FROM SARGASSUM CRASSIFOLIUM ." Journal of Cardiovascular Disease Research 12 (2021), 147-153. doi:10.31838/jcdr.2021.12.03.20



MLA (The Modern Language Association) Style

Syamsudin Abdillah, Pangartika Hikariastri, J.I. Adriana Purukan, Ayu Werawati, Esti Mumpuni, Dian Ratih Laksmitawati,Hendig Winarno, Kusmardi. "THE ANTI-ATHEROSCLEROSIS ACTIVITY OF FUCOIDAN CRUDE EXTRACT FROM SARGASSUM CRASSIFOLIUM ." Journal of Cardiovascular Disease Research 12.3 (2021), 147-153. Print. doi:10.31838/jcdr.2021.12.03.20



APA (American Psychological Association) Style

Syamsudin Abdillah, Pangartika Hikariastri, J.I. Adriana Purukan, Ayu Werawati, Esti Mumpuni, Dian Ratih Laksmitawati,Hendig Winarno, Kusmardi (2021) THE ANTI-ATHEROSCLEROSIS ACTIVITY OF FUCOIDAN CRUDE EXTRACT FROM SARGASSUM CRASSIFOLIUM . Journal of Cardiovascular Disease Research, 12 (3), 147-153. doi:10.31838/jcdr.2021.12.03.20





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