E-ISSN 0976-2833 | ISSN 0975-3583
 

Research Article 


INVESTIGATION ANTIPYRETIC AND ANALGESIC ACTIVITY OF NICLOSAMIDE

RAVI PRATAP PANDEY, MAMTA TIWARI, ANUBHAV DUBEY.

Abstract
The present pharmacological research work was accomplished to explore the analgesic and antipyretic potential
of Niclosamide (50 and 100 mg/kg, p.o.).Acetic acid induced writhing and Eddy’s hot-plate model was used to
evaluate analgesic effect while antipyretic effect was assessed against brewer`s yeast induced pyrexia in rat. In
writhing activity is significantly decreases 27.06% and 49.74% in acetic acid induced analgesia model while
latency period of Eddy’s hot-plate model is significantly increases 12.17±0.310 and 14.34±0.349 at low and
high dose of Niclosamide (50 and 100 mg/kg, p.o.). It also effectively suppress anal temperature at both high
and low doses significantly 96.43±0.009 and 96.42±0.003 respectively in Brewer’s yeast induced pyrexia.
Preliminary experimental outcome is clearly indicates that Niclosamide (50 and 100 mg/kg,p.o.) is having
significant analgesic and antipyretic potential.

Key words: Niclosamide, Pyrexia, Brewer yeast, Accomplished Antipyretic potential


 
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Pubmed Style

RAVI PRATAP PANDEY, MAMTA TIWARI, ANUBHAV DUBEY. INVESTIGATION ANTIPYRETIC AND ANALGESIC ACTIVITY OF NICLOSAMIDE. J Cardiovasc. Dis. Res.. 2021; 12(4): 77-83. doi:10.31838/jcdr.2021.12.04.09


Web Style

RAVI PRATAP PANDEY, MAMTA TIWARI, ANUBHAV DUBEY. INVESTIGATION ANTIPYRETIC AND ANALGESIC ACTIVITY OF NICLOSAMIDE. http://www.jcdronline.org/?mno=89721 [Access: July 26, 2021]. doi:10.31838/jcdr.2021.12.04.09


AMA (American Medical Association) Style

RAVI PRATAP PANDEY, MAMTA TIWARI, ANUBHAV DUBEY. INVESTIGATION ANTIPYRETIC AND ANALGESIC ACTIVITY OF NICLOSAMIDE. J Cardiovasc. Dis. Res.. 2021; 12(4): 77-83. doi:10.31838/jcdr.2021.12.04.09



Vancouver/ICMJE Style

RAVI PRATAP PANDEY, MAMTA TIWARI, ANUBHAV DUBEY. INVESTIGATION ANTIPYRETIC AND ANALGESIC ACTIVITY OF NICLOSAMIDE. J Cardiovasc. Dis. Res.. (2021), [cited July 26, 2021]; 12(4): 77-83. doi:10.31838/jcdr.2021.12.04.09



Harvard Style

RAVI PRATAP PANDEY, MAMTA TIWARI, ANUBHAV DUBEY (2021) INVESTIGATION ANTIPYRETIC AND ANALGESIC ACTIVITY OF NICLOSAMIDE. J Cardiovasc. Dis. Res., 12 (4), 77-83. doi:10.31838/jcdr.2021.12.04.09



Turabian Style

RAVI PRATAP PANDEY, MAMTA TIWARI, ANUBHAV DUBEY. 2021. INVESTIGATION ANTIPYRETIC AND ANALGESIC ACTIVITY OF NICLOSAMIDE. Journal of Cardiovascular Disease Research, 12 (4), 77-83. doi:10.31838/jcdr.2021.12.04.09



Chicago Style

RAVI PRATAP PANDEY, MAMTA TIWARI, ANUBHAV DUBEY. "INVESTIGATION ANTIPYRETIC AND ANALGESIC ACTIVITY OF NICLOSAMIDE." Journal of Cardiovascular Disease Research 12 (2021), 77-83. doi:10.31838/jcdr.2021.12.04.09



MLA (The Modern Language Association) Style

RAVI PRATAP PANDEY, MAMTA TIWARI, ANUBHAV DUBEY. "INVESTIGATION ANTIPYRETIC AND ANALGESIC ACTIVITY OF NICLOSAMIDE." Journal of Cardiovascular Disease Research 12.4 (2021), 77-83. Print. doi:10.31838/jcdr.2021.12.04.09



APA (American Psychological Association) Style

RAVI PRATAP PANDEY, MAMTA TIWARI, ANUBHAV DUBEY (2021) INVESTIGATION ANTIPYRETIC AND ANALGESIC ACTIVITY OF NICLOSAMIDE. Journal of Cardiovascular Disease Research, 12 (4), 77-83. doi:10.31838/jcdr.2021.12.04.09





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