E-ISSN 0976-2833 | ISSN 0975-3583
 

Research Article 


Role of C- reactive protein as an inflammatory marker in sputum smear positive pulmonary tuberculosis patients

Dr.Jasbir Singh, Dr.Kailash Meena, Dr.Surinder Pal Singh, Dr.Harjinder Singh,Dr.Ajaypal Singh.

Abstract
Background: Pulmonary tuberculosis is associated with local inflammation of the lung tissue andincreases the
levels of the inflammatory markers. C Reactive protein is an important inflammatory marker during
pulmonarytuberculosis. The aims of our study were measuringserum CRP level in sputum smear-positive
pulmonary tuberculosis patients at the start and end of the intensive phase of anti-tubercular therapy (ATT)
along with correlation between sputum smear grading and serumCRP level at the start and end of intensive
phase of ATT.
Methods: This was aprospective cohort study and60 patientswithsputum smear-positive pulmonary
tuberculosiswere taken. Serum CRP level and sputum smear grading wasdone at the start and end of the
intensive phase of ATT.
Results: SerumCRP level before the start and at end of intensive phase of ATT showed mean of 11.72 5.53
mg/dl (males - 11.01 5.25, females - 12.77 5.89) and 2.69 1.81mg/dl(males -2.66 1.87, females - 2.72
1.75), respectively. On statistical analysis, the p-value was <0.001, thus making it statically significant.There
was no correlation found between sputum AFB grading and CRP levels.
Conclusion: Serum CRP levels in sputum positive pulmonary tuberculosis patients showed a downward trend at
the end of the intensive phase of anti-tubercular therapy; explained that a decrease in the levels due to control in
the inflammatory process with treatment. Serum CRP level can be used as a follow-up biomarker in pulmonary
tuberculosis.

Key words: Pulmonary tuberculosis,C - reactive protein,Anti-tubercular therapy,Intensive phase


 
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How to Cite this Article
Pubmed Style

Dr.Jasbir Singh, Dr.Kailash Meena, Dr.Surinder Pal Singh, Dr.Harjinder Singh,Dr.Ajaypal Singh. Role of C- reactive protein as an inflammatory marker in sputum smear positive pulmonary tuberculosis patients. J Cardiovasc. Dis. Res.. 2021; 12(4): 293-297. doi:10.31838/jcdr.2021.12.04.34


Web Style

Dr.Jasbir Singh, Dr.Kailash Meena, Dr.Surinder Pal Singh, Dr.Harjinder Singh,Dr.Ajaypal Singh. Role of C- reactive protein as an inflammatory marker in sputum smear positive pulmonary tuberculosis patients. http://www.jcdronline.org/?mno=92526 [Access: July 26, 2021]. doi:10.31838/jcdr.2021.12.04.34


AMA (American Medical Association) Style

Dr.Jasbir Singh, Dr.Kailash Meena, Dr.Surinder Pal Singh, Dr.Harjinder Singh,Dr.Ajaypal Singh. Role of C- reactive protein as an inflammatory marker in sputum smear positive pulmonary tuberculosis patients. J Cardiovasc. Dis. Res.. 2021; 12(4): 293-297. doi:10.31838/jcdr.2021.12.04.34



Vancouver/ICMJE Style

Dr.Jasbir Singh, Dr.Kailash Meena, Dr.Surinder Pal Singh, Dr.Harjinder Singh,Dr.Ajaypal Singh. Role of C- reactive protein as an inflammatory marker in sputum smear positive pulmonary tuberculosis patients. J Cardiovasc. Dis. Res.. (2021), [cited July 26, 2021]; 12(4): 293-297. doi:10.31838/jcdr.2021.12.04.34



Harvard Style

Dr.Jasbir Singh, Dr.Kailash Meena, Dr.Surinder Pal Singh, Dr.Harjinder Singh,Dr.Ajaypal Singh (2021) Role of C- reactive protein as an inflammatory marker in sputum smear positive pulmonary tuberculosis patients. J Cardiovasc. Dis. Res., 12 (4), 293-297. doi:10.31838/jcdr.2021.12.04.34



Turabian Style

Dr.Jasbir Singh, Dr.Kailash Meena, Dr.Surinder Pal Singh, Dr.Harjinder Singh,Dr.Ajaypal Singh. 2021. Role of C- reactive protein as an inflammatory marker in sputum smear positive pulmonary tuberculosis patients. Journal of Cardiovascular Disease Research, 12 (4), 293-297. doi:10.31838/jcdr.2021.12.04.34



Chicago Style

Dr.Jasbir Singh, Dr.Kailash Meena, Dr.Surinder Pal Singh, Dr.Harjinder Singh,Dr.Ajaypal Singh. "Role of C- reactive protein as an inflammatory marker in sputum smear positive pulmonary tuberculosis patients." Journal of Cardiovascular Disease Research 12 (2021), 293-297. doi:10.31838/jcdr.2021.12.04.34



MLA (The Modern Language Association) Style

Dr.Jasbir Singh, Dr.Kailash Meena, Dr.Surinder Pal Singh, Dr.Harjinder Singh,Dr.Ajaypal Singh. "Role of C- reactive protein as an inflammatory marker in sputum smear positive pulmonary tuberculosis patients." Journal of Cardiovascular Disease Research 12.4 (2021), 293-297. Print. doi:10.31838/jcdr.2021.12.04.34



APA (American Psychological Association) Style

Dr.Jasbir Singh, Dr.Kailash Meena, Dr.Surinder Pal Singh, Dr.Harjinder Singh,Dr.Ajaypal Singh (2021) Role of C- reactive protein as an inflammatory marker in sputum smear positive pulmonary tuberculosis patients. Journal of Cardiovascular Disease Research, 12 (4), 293-297. doi:10.31838/jcdr.2021.12.04.34





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