E-ISSN 0976-2833 | ISSN 0975-3583
 

Research Article 


Lipid Metabolism in Experimental Atherosclerosis Induced by Immunization with Human Native High- Density Lipoproteins

Abdulkadhim Zerjawi, Kseniya Fomina, Liubov Beduleva, Igor Menshikov, Igor Cherepanov.

Abstract
The etiology of atherosclerosis, which underlies a broad spectrum of cardiovascular diseases, remains
unknown. There is currently no doubt that autoimmune reactions are involved in the pathogenesis of
atherosclerosis. We previously showed that immunizing rats and rabbits with human native lipoproteins in
incomplete Freundís adjuvant (IFA) results in atherosclerosis-like changes in the aortic wall. However, the
mechanisms of the atherogenic effect of the anti-lipoprotein antibodies, in particular their effect on lipid
metabolism, remain unclear. The aim of this study was to examine lipid metabolism in rats and rabbits with
atherosclerosis-like aortic changes induced by immunization with native human high-density lipoproteins
(nhHDL). For this purpose, we compared the lipid profile of blood plasma and peripheral blood mononuclear
cells (PBMC) in nhHDL/IFA-immunized rats and rabbits and in IFA-injected animals. Histology studies of the
aortic wall in nhHDL/IFA-immunized rabbits and rats revealed atherosclerosis-like changes, while in IFAinjected
rats and rabbits, no aortic changes were found. Changes in the lipid profile of blood plasma and PBMC
were comparable in animals immunized with nhHDL/IFA and those that received only an IFA injection.
Consequently, the changes in the lipid profile of the blood plasma and PBMC of animals immunized with
nhHDL/IFA were induced by the IFA and not associated with the immune reaction to the lipoproteins, while the
atherosclerosis-like changes in the aortic wall of rabbits and rats caused by the immune reaction to native HDL
are not mediated by changes in lipid metabolism

Key words: Atherosclerosis, Animal Models, Autoimmunity, Lipid Metabolism


 
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How to Cite this Article
Pubmed Style

Abdulkadhim Zerjawi, Kseniya Fomina, Liubov Beduleva, Igor Menshikov, Igor Cherepanov. Lipid Metabolism in Experimental Atherosclerosis Induced by Immunization with Human Native High- Density Lipoproteins. J Cardiovasc. Dis. Res.. 2021; 12(4): 322-329. doi:10.31838/jcdr.2021.12.04.39


Web Style

Abdulkadhim Zerjawi, Kseniya Fomina, Liubov Beduleva, Igor Menshikov, Igor Cherepanov. Lipid Metabolism in Experimental Atherosclerosis Induced by Immunization with Human Native High- Density Lipoproteins. http://www.jcdronline.org/?mno=92540 [Access: July 26, 2021]. doi:10.31838/jcdr.2021.12.04.39


AMA (American Medical Association) Style

Abdulkadhim Zerjawi, Kseniya Fomina, Liubov Beduleva, Igor Menshikov, Igor Cherepanov. Lipid Metabolism in Experimental Atherosclerosis Induced by Immunization with Human Native High- Density Lipoproteins. J Cardiovasc. Dis. Res.. 2021; 12(4): 322-329. doi:10.31838/jcdr.2021.12.04.39



Vancouver/ICMJE Style

Abdulkadhim Zerjawi, Kseniya Fomina, Liubov Beduleva, Igor Menshikov, Igor Cherepanov. Lipid Metabolism in Experimental Atherosclerosis Induced by Immunization with Human Native High- Density Lipoproteins. J Cardiovasc. Dis. Res.. (2021), [cited July 26, 2021]; 12(4): 322-329. doi:10.31838/jcdr.2021.12.04.39



Harvard Style

Abdulkadhim Zerjawi, Kseniya Fomina, Liubov Beduleva, Igor Menshikov, Igor Cherepanov (2021) Lipid Metabolism in Experimental Atherosclerosis Induced by Immunization with Human Native High- Density Lipoproteins. J Cardiovasc. Dis. Res., 12 (4), 322-329. doi:10.31838/jcdr.2021.12.04.39



Turabian Style

Abdulkadhim Zerjawi, Kseniya Fomina, Liubov Beduleva, Igor Menshikov, Igor Cherepanov. 2021. Lipid Metabolism in Experimental Atherosclerosis Induced by Immunization with Human Native High- Density Lipoproteins. Journal of Cardiovascular Disease Research, 12 (4), 322-329. doi:10.31838/jcdr.2021.12.04.39



Chicago Style

Abdulkadhim Zerjawi, Kseniya Fomina, Liubov Beduleva, Igor Menshikov, Igor Cherepanov. "Lipid Metabolism in Experimental Atherosclerosis Induced by Immunization with Human Native High- Density Lipoproteins." Journal of Cardiovascular Disease Research 12 (2021), 322-329. doi:10.31838/jcdr.2021.12.04.39



MLA (The Modern Language Association) Style

Abdulkadhim Zerjawi, Kseniya Fomina, Liubov Beduleva, Igor Menshikov, Igor Cherepanov. "Lipid Metabolism in Experimental Atherosclerosis Induced by Immunization with Human Native High- Density Lipoproteins." Journal of Cardiovascular Disease Research 12.4 (2021), 322-329. Print. doi:10.31838/jcdr.2021.12.04.39



APA (American Psychological Association) Style

Abdulkadhim Zerjawi, Kseniya Fomina, Liubov Beduleva, Igor Menshikov, Igor Cherepanov (2021) Lipid Metabolism in Experimental Atherosclerosis Induced by Immunization with Human Native High- Density Lipoproteins. Journal of Cardiovascular Disease Research, 12 (4), 322-329. doi:10.31838/jcdr.2021.12.04.39





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