E-ISSN 0976-2833 | ISSN 0975-3583
 

Original Research 


Factor analysis of risk variables associated with metabolic syndrome in adult Asian Indians

Mithun Das, Susil Pal, Arnab Ghosh.

Abstract
Background: Several studies hinted about the clustering of risk variables of the metabolic syndrome (MS)
and suggested that the underlying genetic polymorphisms could be responsible for the increasing incidence of
coronary heart disease (CHD) in people of Indian origin. Therefore, identi cation of the components of the MS
along with the genetic factors could be one of the aspects to make an attempt to prevent the increasing incidence
of CHD. Materials and Methods: Principal component factor analysis (PCFA) was undertaken to identify the
components or factors of the MS among the adult (30 years) Asian Indians living in and around Calcutta, India.
The study comprised 350 adult Asian Indians. Anthropometric measurements were taken, and lipid pro les,
blood pressure and fasting blood glucose were measured for each participant. Two genetic polymorphisms,
namely, angiotensin converting enzyme (ACE) gene polymorphism (insertion/deletion [I/D]) or ACE (I/D)
and apolipoproteinE (Hha I) were also studied. Results: PCFA revealed 3 factors that cumulatively explained
65.39% of the observed variance of the MS by measured variables. The 3 factors identi ed were lipids and
lipoprotein (Factor 1), centripetal fat and blood pressure (Factor 2), and ACE (I/D) polymorphism with blood
pressure (Factor 3). Moreover, the  rst 2 factors, that is, lipids, lipoprotein, centripetal fat, and blood pressures
cumulatively explained ~46% (45.94%) of the observed variance of MS in this population. Conclusions:
Since more than 1 factor was identi ed for the MS phenotype, more than 1 physiogenetic mechanism could be
accounted for MS in the Asian Indian population.

Key words: Asian Indians, factors, gene polymorphism, metabolic syndrome, obesity


 
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Pubmed Style

Mithun Das, Susil Pal, Arnab Ghosh. Factor analysis of risk variables associated with metabolic syndrome in adult Asian Indians. J Cardiovasc. Dis. Res.. 2010; 1(2): 86-91. doi:10.4103/0975-3583.64442


Web Style

Mithun Das, Susil Pal, Arnab Ghosh. Factor analysis of risk variables associated with metabolic syndrome in adult Asian Indians. http://www.jcdronline.org/?mno=92930 [Access: July 26, 2021]. doi:10.4103/0975-3583.64442


AMA (American Medical Association) Style

Mithun Das, Susil Pal, Arnab Ghosh. Factor analysis of risk variables associated with metabolic syndrome in adult Asian Indians. J Cardiovasc. Dis. Res.. 2010; 1(2): 86-91. doi:10.4103/0975-3583.64442



Vancouver/ICMJE Style

Mithun Das, Susil Pal, Arnab Ghosh. Factor analysis of risk variables associated with metabolic syndrome in adult Asian Indians. J Cardiovasc. Dis. Res.. (2010), [cited July 26, 2021]; 1(2): 86-91. doi:10.4103/0975-3583.64442



Harvard Style

Mithun Das, Susil Pal, Arnab Ghosh (2010) Factor analysis of risk variables associated with metabolic syndrome in adult Asian Indians. J Cardiovasc. Dis. Res., 1 (2), 86-91. doi:10.4103/0975-3583.64442



Turabian Style

Mithun Das, Susil Pal, Arnab Ghosh. 2010. Factor analysis of risk variables associated with metabolic syndrome in adult Asian Indians. Journal of Cardiovascular Disease Research, 1 (2), 86-91. doi:10.4103/0975-3583.64442



Chicago Style

Mithun Das, Susil Pal, Arnab Ghosh. "Factor analysis of risk variables associated with metabolic syndrome in adult Asian Indians." Journal of Cardiovascular Disease Research 1 (2010), 86-91. doi:10.4103/0975-3583.64442



MLA (The Modern Language Association) Style

Mithun Das, Susil Pal, Arnab Ghosh. "Factor analysis of risk variables associated with metabolic syndrome in adult Asian Indians." Journal of Cardiovascular Disease Research 1.2 (2010), 86-91. Print. doi:10.4103/0975-3583.64442



APA (American Psychological Association) Style

Mithun Das, Susil Pal, Arnab Ghosh (2010) Factor analysis of risk variables associated with metabolic syndrome in adult Asian Indians. Journal of Cardiovascular Disease Research, 1 (2), 86-91. doi:10.4103/0975-3583.64442





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