E-ISSN 0976-2833 | ISSN 0975-3583
 

Research Article 


USE OF REDOX REACTION FOR THE ESTIMATION OF BENZIMIDAZOLE DERIVATIVE (LEDIPASVIR) BY SPECTROPHOTOMETRIC QUANTIFICATION

G. KIRAN KUMAR, K. JHANSY LOKESH, G. LALITHA SAI PRIYANKA, K. NAGA RAJU.

Abstract
A simple spectrophotometric methodhas been developed for the significant measurements of ledipasvir in the pure form and pharmaceutical formulations. In this method the solutions of ledipasvir were scanned at two different wavelengths. These methods are based on redox reaction between ledipasvir and ferric chloride which upon complexation with 1, 10 phenanthroline to form a reddish orange colour complex which shows absorption maximum at 520.0nm.In the method 2 the ferric chloride complexes with potassium ferric cyanide to form bluish orange colour complex which show absorption maximum at 713.6nm.These methods accept the beers law. The concentrations of solutions in the range of 10-50g/ml and 20-100g/ml respectively. These methods are also validated as per International council for Harmonization Guidelines and the results were within the acceptance limits. The assay percentage was found to be 99.02% for method 1and 115% for method 2. The developed methods were based on redox reaction used for the analysis of ledipasvir present in various pharmaceutical dosage forms.

Key words: Spectrophotometry, ledipasvir, ferric chloride, 1, 10 phenanthroline, potassium ferric cyanide.


 
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How to Cite this Article
Pubmed Style

G. KIRAN KUMAR , K. JHANSY LOKESH, G. LALITHA SAI PRIYANKA, K. NAGA RAJU. USE OF REDOX REACTION FOR THE ESTIMATION OF BENZIMIDAZOLE DERIVATIVE (LEDIPASVIR) BY SPECTROPHOTOMETRIC QUANTIFICATION. J Cardiovasc. Dis. Res.. 2021; 12(6): 418-423. doi: 10.31838/jcdr.2021.12.06.54


Web Style

G. KIRAN KUMAR , K. JHANSY LOKESH, G. LALITHA SAI PRIYANKA, K. NAGA RAJU. USE OF REDOX REACTION FOR THE ESTIMATION OF BENZIMIDAZOLE DERIVATIVE (LEDIPASVIR) BY SPECTROPHOTOMETRIC QUANTIFICATION. http://www.jcdronline.org/?mno=9301 [Access: December 04, 2021]. doi: 10.31838/jcdr.2021.12.06.54


AMA (American Medical Association) Style

G. KIRAN KUMAR , K. JHANSY LOKESH, G. LALITHA SAI PRIYANKA, K. NAGA RAJU. USE OF REDOX REACTION FOR THE ESTIMATION OF BENZIMIDAZOLE DERIVATIVE (LEDIPASVIR) BY SPECTROPHOTOMETRIC QUANTIFICATION. J Cardiovasc. Dis. Res.. 2021; 12(6): 418-423. doi: 10.31838/jcdr.2021.12.06.54



Vancouver/ICMJE Style

G. KIRAN KUMAR , K. JHANSY LOKESH, G. LALITHA SAI PRIYANKA, K. NAGA RAJU. USE OF REDOX REACTION FOR THE ESTIMATION OF BENZIMIDAZOLE DERIVATIVE (LEDIPASVIR) BY SPECTROPHOTOMETRIC QUANTIFICATION. J Cardiovasc. Dis. Res.. (2021), [cited December 04, 2021]; 12(6): 418-423. doi: 10.31838/jcdr.2021.12.06.54



Harvard Style

G. KIRAN KUMAR , K. JHANSY LOKESH, G. LALITHA SAI PRIYANKA, K. NAGA RAJU (2021) USE OF REDOX REACTION FOR THE ESTIMATION OF BENZIMIDAZOLE DERIVATIVE (LEDIPASVIR) BY SPECTROPHOTOMETRIC QUANTIFICATION. J Cardiovasc. Dis. Res., 12 (6), 418-423. doi: 10.31838/jcdr.2021.12.06.54



Turabian Style

G. KIRAN KUMAR , K. JHANSY LOKESH, G. LALITHA SAI PRIYANKA, K. NAGA RAJU. 2021. USE OF REDOX REACTION FOR THE ESTIMATION OF BENZIMIDAZOLE DERIVATIVE (LEDIPASVIR) BY SPECTROPHOTOMETRIC QUANTIFICATION. Journal of Cardiovascular Disease Research, 12 (6), 418-423. doi: 10.31838/jcdr.2021.12.06.54



Chicago Style

G. KIRAN KUMAR , K. JHANSY LOKESH, G. LALITHA SAI PRIYANKA, K. NAGA RAJU. "USE OF REDOX REACTION FOR THE ESTIMATION OF BENZIMIDAZOLE DERIVATIVE (LEDIPASVIR) BY SPECTROPHOTOMETRIC QUANTIFICATION." Journal of Cardiovascular Disease Research 12 (2021), 418-423. doi: 10.31838/jcdr.2021.12.06.54



MLA (The Modern Language Association) Style

G. KIRAN KUMAR , K. JHANSY LOKESH, G. LALITHA SAI PRIYANKA, K. NAGA RAJU. "USE OF REDOX REACTION FOR THE ESTIMATION OF BENZIMIDAZOLE DERIVATIVE (LEDIPASVIR) BY SPECTROPHOTOMETRIC QUANTIFICATION." Journal of Cardiovascular Disease Research 12.6 (2021), 418-423. Print. doi: 10.31838/jcdr.2021.12.06.54



APA (American Psychological Association) Style

G. KIRAN KUMAR , K. JHANSY LOKESH, G. LALITHA SAI PRIYANKA, K. NAGA RAJU (2021) USE OF REDOX REACTION FOR THE ESTIMATION OF BENZIMIDAZOLE DERIVATIVE (LEDIPASVIR) BY SPECTROPHOTOMETRIC QUANTIFICATION. Journal of Cardiovascular Disease Research, 12 (6), 418-423. doi: 10.31838/jcdr.2021.12.06.54





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