E-ISSN 0976-2833 | ISSN 0975-3583
 

Research Article 


Antioxidant Potential of Kersen LeavesSteeping (Muntingia calabura L.) Against Endogenous Enzyme Superoxide Dismutase (SOD) Levels in Diabetes Mellitus Rats

Ratna Indriawati, Arifin Nugroho.

Abstract
Oxidative stress occurs when the levels of free radicals and antioxidants in the body is not balanced. Free
radicals can be formed as a result of an increase in blood glucose levels in diabetes mellitus that can cause
damage to cells, tissues, and organs such as the liver, kidneys, heart. Antioxidants are necessary to dampen the
negative effects of oxidants. Flavonoids on the cherry crop is antioxidative. This study was investigated the
effectiveness of steeping cherry leaves (Muntingia calabura L.) in increasing levels of the enzyme SOD in
Diabetes Mellitus Rats.The subjects of this study were 36 Sprague Dawley rats divided into 6 groups, namely
group 1 (normal), group 2 (negative control), group 3 (positive control), group 4 (steeping cherry leaves 250
mg/200 grBW), group 5 (steeping kersen leaves 500 mg/200 grBW), and group 6 (steeping cherry leaves 750
mg/200 grBW). Groups 2-6 were induced with streptozotocin and nicotinamide for 5 days until the rats became
Diabetes Mellitus (blood glucose>135 mg/dl) and then treated for 14 days. Data were analyzed using a paired ttest
and One-Way ANOVA test. Statistical test results with paired t-tests showed significant differences in blood
glucose levels before and after treatment (p=0.0001). In the One-Way ANOVA test, there was a different mean
of SOD levels in each group (p=0.0001). The most effective to increase SOD levels is a dose of 750 mg/200
grBW.

Key words: oxidative stress, kersen, diabetes, superoxide dismutase


 
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Pubmed Style

Ratna Indriawati, Arifin Nugroho. Antioxidant Potential of Kersen LeavesSteeping (Muntingia calabura L.) Against Endogenous Enzyme Superoxide Dismutase (SOD) Levels in Diabetes Mellitus Rats. J Cardiovasc. Dis. Res.. 2021; 12(4): 628-635. doi:10.31838/jcdr.2021.12.04.68


Web Style

Ratna Indriawati, Arifin Nugroho. Antioxidant Potential of Kersen LeavesSteeping (Muntingia calabura L.) Against Endogenous Enzyme Superoxide Dismutase (SOD) Levels in Diabetes Mellitus Rats. http://www.jcdronline.org/?mno=98325 [Access: July 27, 2021]. doi:10.31838/jcdr.2021.12.04.68


AMA (American Medical Association) Style

Ratna Indriawati, Arifin Nugroho. Antioxidant Potential of Kersen LeavesSteeping (Muntingia calabura L.) Against Endogenous Enzyme Superoxide Dismutase (SOD) Levels in Diabetes Mellitus Rats. J Cardiovasc. Dis. Res.. 2021; 12(4): 628-635. doi:10.31838/jcdr.2021.12.04.68



Vancouver/ICMJE Style

Ratna Indriawati, Arifin Nugroho. Antioxidant Potential of Kersen LeavesSteeping (Muntingia calabura L.) Against Endogenous Enzyme Superoxide Dismutase (SOD) Levels in Diabetes Mellitus Rats. J Cardiovasc. Dis. Res.. (2021), [cited July 27, 2021]; 12(4): 628-635. doi:10.31838/jcdr.2021.12.04.68



Harvard Style

Ratna Indriawati, Arifin Nugroho (2021) Antioxidant Potential of Kersen LeavesSteeping (Muntingia calabura L.) Against Endogenous Enzyme Superoxide Dismutase (SOD) Levels in Diabetes Mellitus Rats. J Cardiovasc. Dis. Res., 12 (4), 628-635. doi:10.31838/jcdr.2021.12.04.68



Turabian Style

Ratna Indriawati, Arifin Nugroho. 2021. Antioxidant Potential of Kersen LeavesSteeping (Muntingia calabura L.) Against Endogenous Enzyme Superoxide Dismutase (SOD) Levels in Diabetes Mellitus Rats. Journal of Cardiovascular Disease Research, 12 (4), 628-635. doi:10.31838/jcdr.2021.12.04.68



Chicago Style

Ratna Indriawati, Arifin Nugroho. "Antioxidant Potential of Kersen LeavesSteeping (Muntingia calabura L.) Against Endogenous Enzyme Superoxide Dismutase (SOD) Levels in Diabetes Mellitus Rats." Journal of Cardiovascular Disease Research 12 (2021), 628-635. doi:10.31838/jcdr.2021.12.04.68



MLA (The Modern Language Association) Style

Ratna Indriawati, Arifin Nugroho. "Antioxidant Potential of Kersen LeavesSteeping (Muntingia calabura L.) Against Endogenous Enzyme Superoxide Dismutase (SOD) Levels in Diabetes Mellitus Rats." Journal of Cardiovascular Disease Research 12.4 (2021), 628-635. Print. doi:10.31838/jcdr.2021.12.04.68



APA (American Psychological Association) Style

Ratna Indriawati, Arifin Nugroho (2021) Antioxidant Potential of Kersen LeavesSteeping (Muntingia calabura L.) Against Endogenous Enzyme Superoxide Dismutase (SOD) Levels in Diabetes Mellitus Rats. Journal of Cardiovascular Disease Research, 12 (4), 628-635. doi:10.31838/jcdr.2021.12.04.68





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