E-ISSN 0976-2833 | ISSN 0975-3583
 

Research Article 


Design, synthesis, characterization and biological evaluation of some novel 3, 6-disubstituted-2-pyridinecarboxamide derivatives as antidiabetic agents

Dhanraj Patidar, Ashish Jain, Parul Senger.

Abstract
Glucokinase catalyzes the phosphorylation of glucose to glucose-6-phosphate and is predominantly expressed in
liver and pancreatic β-cells. GK acts as a glucose sensor regulating hepatic glucose metabolism and glucosedependent
insulin secretion. At present a lot of anti-hyperglycemic agents are available in market but they exhibits
single mode of action so, select the other targets having multiple action to fulfill the needs to treat type II diabetes,
for that we have synthesized some compounds by using moiety 3, 6-disubstituted 2-pyridinecarboxamide through
structure activity relationship. Such newly synthesized compounds are elucidated by IR, 1H-NMR and Mass
spectroscopy. These synthesized compounds were evaluated for their anti-diabetic activity. Comeouts of in vivo
antihyperglycemic activity specified that substitution of pyridine ring at 3rd position with hydrophobic group like
methyl group enhances the antihyperglycemic activity shown in compound 5g, 5h and 5i. The replacement of H
from the 4th postion of 1,3-thiazol-2-yl amide nucleus by methyl and ethyl group led to decreased antidiabetic
activity. It means that increase the carbon chain on such position decreased antidiabetic activity which can be seen in
compounds of 5g, 5h and 5i, and in compounds 5j, 5k and 5l respectively.

Key words: 3, 6-disubstituted 2-pyridinecarboxamide, Diabetes mellitus, Glucokinase activator, Oral glucose tolerance test, Spectroscopy, Structure activity relationship


 
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Pubmed Style

Dhanraj Patidar, Ashish Jain, Parul Senger. Design, synthesis, characterization and biological evaluation of some novel 3, 6-disubstituted-2-pyridinecarboxamide derivatives as antidiabetic agents. J Cardiovasc. Dis. Res.. 2021; 12(4): 694-701. doi: 10.31838/jcdr.2021.12.04.79


Web Style

Dhanraj Patidar, Ashish Jain, Parul Senger. Design, synthesis, characterization and biological evaluation of some novel 3, 6-disubstituted-2-pyridinecarboxamide derivatives as antidiabetic agents. http://www.jcdronline.org/?mno=99270 [Access: July 26, 2021]. doi: 10.31838/jcdr.2021.12.04.79


AMA (American Medical Association) Style

Dhanraj Patidar, Ashish Jain, Parul Senger. Design, synthesis, characterization and biological evaluation of some novel 3, 6-disubstituted-2-pyridinecarboxamide derivatives as antidiabetic agents. J Cardiovasc. Dis. Res.. 2021; 12(4): 694-701. doi: 10.31838/jcdr.2021.12.04.79



Vancouver/ICMJE Style

Dhanraj Patidar, Ashish Jain, Parul Senger. Design, synthesis, characterization and biological evaluation of some novel 3, 6-disubstituted-2-pyridinecarboxamide derivatives as antidiabetic agents. J Cardiovasc. Dis. Res.. (2021), [cited July 26, 2021]; 12(4): 694-701. doi: 10.31838/jcdr.2021.12.04.79



Harvard Style

Dhanraj Patidar, Ashish Jain, Parul Senger (2021) Design, synthesis, characterization and biological evaluation of some novel 3, 6-disubstituted-2-pyridinecarboxamide derivatives as antidiabetic agents. J Cardiovasc. Dis. Res., 12 (4), 694-701. doi: 10.31838/jcdr.2021.12.04.79



Turabian Style

Dhanraj Patidar, Ashish Jain, Parul Senger. 2021. Design, synthesis, characterization and biological evaluation of some novel 3, 6-disubstituted-2-pyridinecarboxamide derivatives as antidiabetic agents. Journal of Cardiovascular Disease Research, 12 (4), 694-701. doi: 10.31838/jcdr.2021.12.04.79



Chicago Style

Dhanraj Patidar, Ashish Jain, Parul Senger. "Design, synthesis, characterization and biological evaluation of some novel 3, 6-disubstituted-2-pyridinecarboxamide derivatives as antidiabetic agents." Journal of Cardiovascular Disease Research 12 (2021), 694-701. doi: 10.31838/jcdr.2021.12.04.79



MLA (The Modern Language Association) Style

Dhanraj Patidar, Ashish Jain, Parul Senger. "Design, synthesis, characterization and biological evaluation of some novel 3, 6-disubstituted-2-pyridinecarboxamide derivatives as antidiabetic agents." Journal of Cardiovascular Disease Research 12.4 (2021), 694-701. Print. doi: 10.31838/jcdr.2021.12.04.79



APA (American Psychological Association) Style

Dhanraj Patidar, Ashish Jain, Parul Senger (2021) Design, synthesis, characterization and biological evaluation of some novel 3, 6-disubstituted-2-pyridinecarboxamide derivatives as antidiabetic agents. Journal of Cardiovascular Disease Research, 12 (4), 694-701. doi: 10.31838/jcdr.2021.12.04.79





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